4TNM


Conserved Protein Domain Family
IBB
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pfam01749: IBB 
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Importin beta binding domain
This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.
Links
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Statistics
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PSSM-Id: 426408
Aligned: 170 rows
Threshold Bit Score: 59.0869
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4TNM_A         12 RRNRYKVAV--DAEEGRRRREDNLVEIRKNKREENLQKKRFTssmafgsatgqteQ-----------DLSSANQLKDNLP 78  thale cress
EEZ98092        6 RIRSFKNKGk-DCEEMRRRRAGQTIELRKAKKEDQLLKRRNIs------------Lqeeas--tplqeNNSVSLITMSAE 70  red flour beetle
EEB19325       12 RLANFKHKGk-DIEEMRRRRNSVTINLRKASRYDQLLKKRNVsvnesp-------------yafqdgNASTQSNSVMTVP 77  human body louse
EFX68294        9 RLKDFKNKGr-DVEEMRRRRTEVNVELRKAKKEDHLLKRRNLe------------Iddepl--splqeQNRMAAANMSIE 73  common water flea
14_pfamImport   1 RISKFKFQGkfD--EARRRRTEVSVELRKAHKDNQLLKKRNIn------------Iedeplsp---psdqkspVFNMSID 63 
19_pfamImport   1 RQNSYKSHSi-NTTEGRARRHEVTLELRKAKKEDQLFKRRNI-------------Neddvt--splkeVNGQSPKQMTVD 64 
XP_002036427    9 RQGSYKANSi-NTQDSRMRRHEVTIELRKSKKEDQMFKRRNI-------------Ndedlt--splkeLNGQSPVQLSVD 72  Drosophila sec...
Q16KJ6         12 RLASYKHGVk-SNAELRQRRHEVTVELRKNKKEDQLFKRRNIt-----------sEeptvt--splqeSNAQSPVALKFE 77  yellow fever m...
17_pfamImport   1 RLAAYKHGSk-SNTELRQRRHEVTVELRKNKKEDQLLKRRNIt------------Edegpt--splqeNNAQSPVTLKFD 65 
XP_009021038    6 RLKNYKNKGr-GVEDLRRQRSEASVELRKAKKEEQFLKRRNM-------------NeepeqlplqenNSQSQVNPVMPLD 71  Helobdella rob...

4TNM_A         79 AMVAGI-WSEDSNSQLEATN 97  thale cress
EEZ98092       71 EILMGM-MSPDENLQFKATQ 89  red flour beetle
EEB19325       78 EIMSAI-TSGDENFVFEALQ 96  human body louse
EFX68294       74 DIVNGI-NSGDENKEITATH 92  common water flea
14_pfamImport  64 EIIAGM-TSEDDQAMLQATQ 82 
19_pfamImport  65 EIVMAM-NSNDADRQFQGVQ 83 
XP_002036427   73 EIVAAM-NSEDQERQFLGMQ 91  Drosophila sechellia
Q16KJ6         78 EILAYV-NSGNAQKEFVAIQ 96  yellow fever mosquito
17_pfamImport  66 DIMQYI-RSGQPEKEFAAVQ 84 
XP_009021038   72 EIKRVFiSSSNPELLFQAVQ 91  Helobdella robusta
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