1B78,3S86,3TQU


Conserved Protein Domain Family
Ham1p_like
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pfam01725: Ham1p_like 
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Ham1 family
This family consists of the HAM1 protein and hypothetical archaeal bacterial and C. elegans proteins. HAM1 controls 6-N-hydroxylaminopurine (HAP) sensitivity and mutagenesis in S. cerevisiae. The HAM1 protein protects the cell from HAP, either on the level of deoxynucleoside triphosphate or the DNA level by a yet unidentified set of reactions.
Links
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Statistics
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PSSM-Id: 426398
Aligned: 1065 rows
Threshold Bit Score: 62.467
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1B78_A          11 IYFATGNPNKIKE--------------A---------N-------IILkdlkdv-------eieqiKisypEIQ-GTLEE 52  Methanocaldoc...
WP_012472773     6 LTFVTGNNGKFKE--------------V---------E---------RyinelaptitlkqaaidlP----ECQsLDIRT 49  Candidatus Am...
XP_003237433     9 lHFVTGNVKKLAE--------------A---------K-------GILgdiielt-----sqaidiP----EIQg-SLDE 48  Trichophyton ...
XP_002478921    21 LTFVTSNADKIRE--------------V---------T-------SICkrygisv----svmgidlP----ELQg-SIEE 61  Talaromyces s...
EAX98879         5 ITFVTGNKNKLRE--------------A---------Q-------EILgvklvn-------leidiP----ELQlFTSEE 43  Trichomonas v...
XP_650341        3 vRIVTSNPHKAKE--------------I---------N-------EILkdlglqi----givninlM----EIQe-SPLN 43  Entamoeba his...
CDE68384       211 IYFSSTNKKKKEMvq----------fiFhnynidvsfVkppieltEP------------------------QIEkPELEE 256 Clostridium s...
Q11FT9          17 IFFYTSNADKLIQar----------liF---------MrsgyqltHY------------------------RSRhEPYDE 53  Chelativorans...
Q07YD4           4 LIFFTSNRVKTQHakylcrdfnikvinF-----------------SE------------------------KTKrANYDE 42  Shewanella fr...
jgi:Ilyop_1630   4 IVFVTTNKGKIASaq----------eyLnttklipynA-------ELI-----------------------EPRsDDIRK 43  Ilyobacter po...

1B78_A          53 -VAEFGAk-----------W---VY-NIl-KKP----VI-VEDSGFFVEALN-G-----FPGTYSKFVQE-TIGN--E-G 100 Methanocaldoc...
WP_012472773    50 -VALGKAq-----------K---AW-ELlqAP-----VL-IDDGGIYLERYH-Q-----FPGTLSKYVYQgIGLNgiW-L 100 Candidatus Am...
XP_003237433    49 -IARDKCq-----------K---AA-DAvgGP-----VL-VEDSGLGFNALG-G-----LPGPYIRHFYArLGNDglY-N 99  Trichophyton ...
XP_002478921    62 -VAREKCr-----------Q---AA-LAvnGP-----VL-IEDSALIFHALN-G-----LPGPYIKWFYHsLGLQglN-R 112 Talaromyces s...
EAX98879        44 -VALYKAk-----------E---AA-KIvgGP-----VI-VDDTALHFNAIA-G-----LPGAYIRAFVTrLRPFeiA-R 94  Trichomonas v...
XP_650341       44 -IIEYKAk-----------E---AI-KHsnTP-----VI-VEDVSFNLKCMG-E-----LPGPYIKYFVQsIGPAglY-K 94  Entamoeba his...
CDE68384       257 -ERKLVSlplk----tvsrFintVPyA-------------IEDTMLFVEFFNrNgkqweLPGLDTKRWlrq---iglD-G 314 Clostridium s...
Q11FT9          54 dYSLDTQgll-------tqAlkqVSqE-----FerrsVLfVEDTSLRIEALS-Gat--dYPGTRVKEWfse---tsfA-E 114 Chelativorans...
Q07YD4          43 pRIDNREqllkisienaikQa-nLSgL-----GknkpFI-IEDTSVDIHALS-RkykkeYPGVDIKYWmq-----qiKfI 109 Shewanella fr...
jgi:Ilyop_1630  44 -IAKEKVi-----------QaynIVnE-----P----CI-ALDAGFFIKALN-G-----FPRAYVNHAlet---igvE-G 91  Ilyobacter po...

1B78_A         101 ILKLLE----GKDNRNAYFK-TV--I-------GYCD---------------------ENGVRLFK-GIVKG-------- 136 Methanocaldoc...
WP_012472773   101 LAKED------Pr-aYFLS--CL--V-------YITS---------------------PTDYHFFE-GICQG-------- 132 Candidatus Am...
XP_003237433   100 LLAAY------Pd-kSARAA-CT--Y-------AYSAgp------------------gSEP-LLFQ-GYTEG-------- 134 Trichophyton ...
XP_002478921   113 ILADH------Ed-kSAAAV-CT--F-------AFSWgprpaptnedsdsdggdgsssEPEVFLFQ-ARNEG-------- 166 Talaromyces s...
EAX98879        95 LLDSY------Ed-kSAYVT-CS--I-------GFCAgp------------------nDEV-KVIT-GRVNG-------- 129 Trichomonas v...
XP_650341       95 MAKGF------Dd-yRAQAI-LS--I-------GLTRke------------------sDEV-VKIQ-AIIEG-------- 129 Entamoeba his...
CDE68384       315 LLEIMGn--tSK--RKARFVsQT------------GAy-------------------vKSNKYYFGrGEIYGsiayhksq 359 Clostridium s...
Q11FT9         115 LDRQIAlrggDR--R------CTvkSdialrlpTLS------------------------RPVFFH-GETSGcvaeaapt 161 Chelativorans...
Q07YD4         110 DLDLELellgNN--RSVTIR-SD--L-------VLYFpe------------------lSDLPLYFT-GTTDG-------- 150 Shewanella fr...
jgi:Ilyop_1630  92 ILKLME----DKTEQECEFRsCL----------AFYD---------------------GSHMEFFE-SKSSG-------- 127 Ilyobacter po...

1B78_A         137 -RVSEE--I-R--SKGyGF--AY-----D-----SIFIPEeE-ER-TFAEMT-TEEKSQ--ISHRKKAFEEFKKF 188 Methanocaldococcus...
WP_012472773   133 -IMIEP--V-NevLDS-HL--PY-----T-----YMFVP--NgQTkTMAQLRnTEAEKE--FHHRLKATKQLINY 186 Candidatus Amoebop...
XP_003237433   135 -VIVP---K-R--GSG-GF--AF-----D-----PIFEY----QGhTYAEMS-FEEKNR--VSERFRALEKLKAW 182 Trichophyton rubru...
XP_002478921   167 -KVVP---E-R--GDF-GF--AY-----D-----PIFEY----EGkTYSELQ-PEVKNQ--VSDRSKALTKFIDW 214 Talaromyces stipit...
EAX98879       130 -KIVH---P-R--GEG-GF--GF-----D-----PIFQP--DgYDkTYAELS-EEDKNN--CSHRGNALRQFKEs 179 Trichomonas vagina...
XP_650341      130 -KVVE---P-R--GSN-GF--GF-----D-----SCFVP--EgYDkTYAEMS-EVEKNQ--CSHRGVGYRKLAQW 179 Entamoeba histolyt...
CDE68384       360 iDI-----PrY--GTYpYF---F-----H-----LIFIP--DgAEkTLAEMN-MYEYAQ--YDYMRKSIVQLiye 409 Clostridium sp. CA...
Q11FT9         162 fTT-SPqyPwL--TPD-TFn-GW-------------FVP--EgTKrRLGEME-FEESLS--YDFRAKSLTLLVER 213 Chelativorans sp. ...
Q07YD4         151 -KIT---------ATDnQFdtNViypwlDnktfnRWFIP--KnETvVISKLP-IEKADL--HDFRGLAFKKLLDF 210 Shewanella frigidi...
jgi:Ilyop_1630 128 -TL-SK--SiR--GQDsHK---------KwsdlwYVFIPK-NfDK-TLAEFS-EEDFAKyqTLKEDSAINKFAqw 184 Ilyobacter polytro...
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