2UV9,3HYK


Conserved Protein Domain Family
ACPS
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pfam01648: ACPS 
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4'-phosphopantetheinyl transferase superfamily
Members of this family transfers the 4'-phosphopantetheine (4'-PP) moiety from coenzyme A (CoA) to the invariant serine of pfam00550. This post-translational modification renders holo-ACP capable of acyl group activation via thioesterification of the cysteamine thiol of 4'-PP. This superfamily consists of two subtypes: The ACPS type and the Sfp type. The structure of the Sfp type is known, which shows the active site accommodates a magnesium ion. The most highly conserved regions of the alignment are involved in binding the magnesium ion.
Links
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Statistics
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PSSM-Id: 426364
Aligned: 149 rows
Threshold Bit Score: 36.0472
Created: 19-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2UV9_A       1760 RVGVDVEsvdSINiDneeFIS----RNFTER-EQAYCRRAPNPRA--SFAGRWTAKEAIFKSLgvaSKGA--GAAMREIE 1830 Thermomyces l...
CAN00145      109 GIGIDATparPLPgGvlaRVAdl--gsAPVAaGLDALRATGVEAPg---SVLFAAAEAVAKAR---TSAQggWHGIDGAE 180  Clavibacter m...
CAN00355      119 TIGIDAEphaPLP-R---EARdi--vgLAGElHPHPPLGAGVHAD----CVLFSAKESVGKAH---FARYreWLGFADLH 185  Clavibacter m...
Q98JF2        114 SLGIDVE-------PaepLPDdifaIVATGA-DRTGAAD-PRLAG----RILFAAKEAVYKAA---YPLDreVLGYEDIA 177  Mesorhizobium...
WP_005862638  110 RLGIDLE-------AdkpLDPdlvpEICLPS--------EYGTPA----VRVFSAKEAVFKAE---YPHTrvMHGLHGIE 167  Sagittula ste...
CBG67381       88 AVGVDIEdtaVTErm--------arFVFRRReRQTLLAPAGEYSP----GELFVAKEAAFKALn--AIAV--LGDFVFWQ 151  Streptomyces ...
WP_012140389   77 KIGVDVE---ELKqR---NFDgvakFCFNKK-ESEIYANAKDKMQ--KFYEIYTAKEAVIKAK---NLAFsdLAGVGFDQ 144  Campylobacter...
EDK13644      108 AVGIDIE---FPKiR---NFTalmeHIAPKE-EIDWFHHQQNSLN--AFYRCWCLREAVLKSQ---GFGIvkLSNVRHFP 175  Haemophilus i...
EAW41569      104 SIGIDVEhhrPKSvAkv------vhRYFWPE-GQTHFANCSEAESkaWFYRQWCIREALVKYQ---GDGN--LFQLLGMP 171  marine gamma ...
Q311J5        128 QIGVDIEihsHSI-----SYHtiieNYFSPT-EIAIWKKTNPANSkkAFYRLWTLKEAVFKCI---GSGL--LIPLNGIT 196  Desulfovibrio...

2UV9_A       1831 VINdanga---pevhLHGAAAEAAKQAgvktvnvsishGDLQAVAV 1873 Thermomyces lanuginosus
CAN00145      181 IVLhpdgs--------------------------favrARRGPDFT 200  Clavibacter michiganensis subsp. michiganensis ...
CAN00355      186 VTLhpdga--------------------------ftarRSAPGPIP 205  Clavibacter michiganensis subsp. michiganensis ...
Q98JF2        178 VDLdagra-----ttktGRKVSLAYCI-----------APRVVvla 207  Mesorhizobium loti
WP_005862638  168 VDLaegca----rytdHPEVAAIPPE------------SRRPLCVA 197  Sagittula stellata
CBG67381      152 IQLsrsgd--vlrasYGGASVPVRVRSq----------TDLSLAVA 185  Streptomyces scabiei 87.22
WP_012140389  145 MQRryiii---nnlfIICLAFKHS--------------KDIIVKFL 173  Campylobacter concisus
EDK13644      176 EQQkifsdycpqgqlWFTDELPIYLAAfvn------hqEKLPHFYE 215  Haemophilus influenzae 22.4-21
EAW41569      172 LQLtpgtr---glisQNKTTTVAVISS-----------GGAQPELC 203  marine gamma proteobacterium HTCC2080
Q311J5        197 ITLtgghs--aiahaDNGLPLPFTLLHghi-----hntASWAVAVr 235  Desulfovibrio alaskensis G20
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