6R9T


Conserved Protein Domain Family
I_LWEQ

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pfam01608: I_LWEQ 
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I/LWEQ domain
I/LWEQ domains bind to actin. It has been shown that the I/LWEQ domains from mouse talin and yeast Sla2p interact with F-actin. I/LWEQ domains can be placed into four major groups based on sequence similarity: (1) Metazoan talin; (2) Dictyostelium TalA/TalB and SLA110; (3) metazoan Hip1p; and (4) yeast Sla2p. The domain has four conserved blocks, the name of the domain is derived from the initial conserved amino acid of each of the four blocks.
Statistics
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PSSM-Id: 460265
Aligned: 80 rows
Threshold Bit Score: 57.2089
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6R9T_A       2385 DDGQ-WSQGLISAARMVAAATNNLCEAA-NAAVQgh---asQEKLISSAKQVAASTAQLLVACKVKADQDSEAMK---RL 2456
XP_004993026 1393 KSFA-RARGLVRQVQDVTDAVVWLCDSC-SLAAAgq---edLPQVMTRGQNLRTSAAHLQTAAEFKVGRLGRGQSlltAV 1467
XP_654777    1266 RDAN-WEEGLISAAKTVTGCIQYLVKAAnDQVIHnk---psEAMLVACAKSVAANAMQLQAASMVNLALDDPMRD---KL 1338
XP_655382     556 NNEV-WSEGLLSCAKKIVEWAQYISSALmNGe--------pDERILAGLKQFKSHCSQLLTAARVSMEDQSPLLQ---RL 623 
XP_003975000  449 ATEQrYNKLKEKHTELVASHAELLRKSA-DTVRMlsatqqtQDEVERTKHQLSFEIDRVKQESDMKLEEQKFEME---KL 524 
XP_004997176 2396 EEAQ-WSASMVSAAKLVAFATQNLCEAA-NATVQgg---saDEKLVASAKSVANSTAQLMLACRAKMDAQSPTAK---RL 2467
EDQ91246     1388 GDENsTAADLVAAAKLVAHATQELCDGA-NASMRgd---lsQERLVAAAKSIAKSTAQLIMACKVKMPSNSGPMR---RL 1460
KJE98142      717 FAVGvWSEGLVSAAREVAEYTSMLRAAA-EGLSNgt---rpLMDLPASARAVAAATMQLVLAGSTRNPNQAVQL----RL 788 
EGF83358     2387 SDGT-WNDGLVSAAKQVAASTSELCEAA-NEVVKgs---aqHDRVIVCARNVSSFTVQLLTAAAVRSDSSSQTQI---RL 2458
XP_654303    1190 RDKE-YAEELIKAVEDVKSTAIELQQKIkEDNVN-------SDELVKVADKVGKKVEKVVVSCRAGTRTKGRSHKy-kDL 1260
6R9T_A       2457 QAAGNAVKRASDNLVKAAQKAAAFEEQe---------------nETVVV-KEK--MVGGIAQIIAAQEEMLRKERELEEA 2518
XP_004993026 1468 KGSISKVYSATAAFTKLCQEQLAKQTKqrasa-------------pavsiPDRgsAVARQRQIMEEQAAIMRLESELDQR 1534
XP_654777    1339 ASTIKKITDSQSAFVKTVSQGADARSEva--------------------pPKArnAQQLRIMLMEASVNISNIEKELQQA 1398
XP_655382     624 EKSLCSLMSQIQKIIQNILSREQEQRQeik-----------------eqnKTQdnGIESKKELMESQVRVLQLQKELEKA 686 
XP_003975000  525 RRELEEKMAEVTRIKANLQSSEKVSEQa----------------SSSMT-ALQaeKERLMRSVSEKEAELSSLRQAAQVQ 587 
XP_004997176 2468 LAAGSAVKKAADHLVESAKTALEEAQEad--------------------mSLDerPVQSMRQEIEAVEAVLKQERELEAA 2527
EDQ91246     1461 QAAGSAVKKAAENLVRTVQAAPTDVEDs---------------------iQLDasRVHAMKQEIEAVEAIVKQERELEVA 1519
KJE98142      789 HDAGAAVRHVCDKLSAAQLQQTISQMPads-----------------apaMSAssLAAQRAAELEARSKVLQMERNLEKA 851 
EGF83358     2459 RAAGKAVTDATEQLVEAAKGNNTIQDNdmsa----------------vdaELFisPTKSKVLEMEAQMNILRMEKELERA 2522
XP_654303    1261 LDASKKLADATKNLLECAKKVDEFDDTpvvvqmnlppppppvteVEEEEdIETfgIDQYTLKEIEQQKKIFELEKKLEAA 1340
6R9T_A       2519 RKKLAQIRQQ-QYK 2531
XP_004993026 1535 RTTLHGLRRS-HYN 1547
XP_654777    1399 QEELLRMRRA-RYG 1411
XP_655382     687 QNHLYSLRKE-EYN 699 
XP_003975000  588 QSSLQQEQEK-NTR 600 
XP_004997176 2528 KRNLAKLRAT-KYK 2540
EDQ91246     1520 KRALAKIRAN-KYG 1532
KJE98142      852 REDLHSVHKA-KYV 864 
EGF83358     2523 RVGLAAVRKG-RYA 2535
XP_654303    1341 KKKKADLEELaKSF 1354
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