Conserved Protein Domain Family
Basic

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pfam01586: Basic 
Myogenic Basic domain
This basic domain is found in the MyoD family of muscle specific proteins that control muscle development. The bHLH region of the MyoD family includes the basic domain and the Helix-loop-helix (HLH) motif. The bHLH region mediates specific DNA binding. With 12 residues of the basic domain involved in DNA binding. The basic domain forms an extended alpha helix in the structure.
Statistics
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PSSM-Id: 460258
Aligned: 31 rows
Threshold Bit Score: 68.211
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003221172   3 MDLFETGSYFF----YL-DGENGALQQLDVAgegspLYPGSEGTlS-PSSCQdplgaeagigegggrgsEgsspAGEAHV 76 
XP_007228165  14 DDFYDDPCFNTndmhFFeDLD-PRLVHVS-------LLKPDEhg-----------------------------hAEDEHV 56 
XP_005814488  73 DDFYDDPCFNTtdmhFFeDLD-PRLVHGV-------PLKPEDSFsPsSSLSSsspspcshlhhqlqhpeAe----dDEHV 140
XP_005449194  14 DDFYDDPCFNTsdmhFFeDLD-PRLVHVG-------LLKPDDSSsSsSSSPSssssspssllhlhhhaeVe----dDEHV 81 
XP_003214790  25 EDFYDDPCFNTsdmhFFeDLD-PRLVHVGG------LLKPEEphhhg------------------gpgeA------DEHI 73 
P16075        21 DDFYDDPCFNTsdmhFFeDLD-PRLVHVGG------LLKPEEhphtr-----------------apprePt----eEEHV 72  chicken
EOB07757      10 ELFYDSSCLSSpegeFPeDFEPRDLPPFG-------AHQPAE---PaCSE-------------------------EEEHV 54 
Q8QG50        13 EFFYDSSCIPSpeegYTeDYE-HGMSLYGAHkk--dLQESDE----------------------------------DEHV 55  tropical clawed...
XP_852162     13 EYFYDGACIPSpegdFGdELE-ARGAAFG---------ARRA---AlPGPDE------------------------DEHV 55 
CAG12487       3 DDLYDDPCFSSgdlnFFdDLD-ARL-----------LLKPDGhqrlhhh-------------vpsaeeeLeeeaGVEEHV 57  spotted green p...
XP_003221172  77 LAPPclqaPHGPGQCLVWACKTCKRKSAPTD 107
XP_007228165  57 RAPSg---HHQAGRCLLWACKACKRKTTNAD 84 
XP_005814488 141 RVPSg---HHQAGRCLLWACKACKRKTTNAD 168
XP_005449194  82 RAPSg---HHQAGRCLLWACKACKRKTTNAD 109
XP_003214790  74 RAPSg---HHAAWRCLLWACKACKRKTTNAD 101
P16075        73 RAPSg---HHQAGRCLLWACKACKRKTTNAD 100 chicken
EOB07757      55 RAPSg---HHQAGHCLMWACKACKRKSTTMD 82 
Q8QG50        56 RAPIg---HHQAGNCLMWACKACKRKSSTMD 83  tropical clawed frog
XP_852162     56 RAPTg---HHQAGHCLLWACKACKRKSTTTD 83 
CAG12487      58 RAPGg---LHQAGRCLLWACKA--------- 76  spotted green pufferfish
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