6J57,2WQT


Conserved Protein Domain Family
FAA_hydrolase

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pfam01557: FAA_hydrolase 
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Fumarylacetoacetate (FAA) hydrolase family
This family consists of fumarylacetoacetate (FAA) hydrolase, or fumarylacetoacetate hydrolase (FAH) and it also includes HHDD isomerase/OPET decarboxylase from E. coli strain W. FAA is the last enzyme in the tyrosine catabolic pathway, it hydrolyzes fumarylacetoacetate into fumarate and acetoacetate which then join the citric acid cycle. Mutations in FAA cause type I tyrosinemia in humans this is an inherited disorder mainly affecting the liver leading to liver cirrhosis, hepatocellular carcinoma, renal tubular damages and neurologic crises amongst other symptoms. The enzymatic defect causes the toxic accumulation of phenylalanine/tyrosine catabolites. The E. coli W enzyme HHDD isomerase/OPET decarboxylase contains two copies of this domain and functions in fourth and fifth steps of the homoprotocatechuate pathway; here it decarboxylates OPET to HHDD and isomerizes this to OHED. The final products of this pathway are pyruvic acid and succinic semialdehyde. This family also includes various hydratases and 4-oxalocrotonate decarboxylases which are involved in the bacterial meta-cleavage pathways for degradation of aromatic compounds. 2-hydroxypentadienoic acid hydratase encoded by mhpD in E. coli is involved in the phenylpropionic acid pathway of E. coli and catalyzes the conversion of 2-hydroxy pentadienoate to 4-hydroxy-2-keto-pentanoate and uses a Mn2+ co-factor. OHED hydratase encoded by hpcG in E. coli is involved in the homoprotocatechuic acid (HPC) catabolism. XylI in P. putida is a 4-Oxalocrotonate decarboxylase.
Statistics
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PSSM-Id: 426322
Aligned: 43 rows
Threshold Bit Score: 105.818
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6J57_A         69 Ki-VCVGLNYANHIKEMGr---------DLPDtp--------tLFVKFPDALIGPFDDVVVPEWan-------------- 116 Corynebacteriu...
jgi:Daci_0212  54 Rv-AGSQQGPGRVPGYWKsga----prrDAPLthap---lpeeGVWASPSVAGG--APLHLRGI---------------- 107 Delftia acidov...
2WQT_Q         55 rrvVGRKVGLTHPKVQQQlg-------vDQPDfgtl---fadmC-YGDNE--IIPFSRVLQPRI---------------- 105 Escherichia co...
jgi:M446_2715  81 Rh-AAAWPGHVRLLRQAEga-------eAPSDsgtplrhaasdGFLAPRATLPA------DPAAs--------------- 131 Methylobacteri...
Q4J6Y6         99 AntVRDFLAFRGHVEASYkrrg---qqiPEEWfki------piYYKGDPAAFYGHMENVPWPSYsn-------------- 155 Sulfolobus aci...
Q162G6        121 vteFTDFYAGRHHAFNVGslfrdpanalPPNWlhi------piGYNGRASSVVVSGTDITRPNGqlkapdaem--pvfea 192 Roseobacter de...
CAK38680      112 N--FSDFYCSFEHTRNV------------PSWfvi------psVYNGRQSSLRISGTPIRRPWGvtldsnkpndppafrp 171 Aspergillus niger
WP_000674021   77 pssIRDFYAFEQHVKTARgrrg---ldvVPEWydi------pvFYFTNHRAVIGPNDVVIGPKKse-------------- 133 Bacillus
Q9CKS8         19 Tv-FVIALNSTQLLQRCQaq------feQAPYqalp---ktpvIYVLPEATHNRSGANVSLPAGkk-------------- 74  Pasteurella mu...
Q63MG5         18 gtvYGALLNDRGALAALGda------vhAPPYhkpp---rasvLYVKPANTHAGDGAAVVVPAGvd-------------- 74  Burkholderia p...
6J57_A        117 -kaLDWEGEMAVIIGK--RARRV-----KQADAAEYIAGYAVMNDYT-TRDFQYAAPaktpQWHQGKSLekSAGFGPW-- 185 Corynebacteriu...
jgi:Daci_0212 108 ------EAEIALRLGR--DVTAEmaaalQPGEGLELIDGITAAIEVVdTRWRQHLKApp-lLLAADGLChgALVLGPWqd 178 Delftia acidov...
2WQT_Q        106 ------EAEIALVLNR--DLPATd---iTFDELYNAIEWVLPALEVVgSRIRDWSIQf--vDTVADNAScgVYVIGGP-- 170 Escherichia co...
jgi:M446_2715 132 ---LDVSAGLAVITGD--VAQGT-----APAQAAGAVRLVTLVTEVI-RRDRLKPDGld-lDGPLAAGF--AASLGPV-- 195 Methylobacteri...
Q4J6Y6        156 --aLDFELEIGAIVYR--KGVNI-----EKRKARDYILGYTIFNDFS-ARDIQMREMtcl--lgpAKGKdfANGLGPW-- 221 Sulfolobus aci...
Q162G6        193 skrFDLELEMGAIVGK--PSKGRv----SVQEADDMIFGYVLLNDWS-ARDIQAWEYqp-lGPFQAKAT--ATTISPW-- 260 Roseobacter de...
CAK38680      172 sarFDFELEMGVYLSHplPPGEIl----NINNAKDHIFGLVILNDWS-ARDIQTYEMap-lGPFHSKGS--GTSISPW-- 241 Aspergillus niger
WP_000674021  134 --kIDYELEIACVIGK--EGRNI-----SREQAEEYIFGYCIMNDWS-ARDLQATEMkvglGPAKGKDF--ATSLGAH-- 199 Bacillus
Q9CKS8         75 --qLRMEPHLAVVFGR--DTSRVc-----vEQAMHYVSGYLPVALYSlPHDsy------yrPDIEGRCQegFCVLGQE-- 137 Pasteurella mu...
Q63MG5         75 --aLEIGATLGVVFAR--RTTRV-----PAEQAFDFVKGFTLASDVS-I---PHPDYy--rPAVRFKCRdgFCPLGPA-- 137 Burkholderia p...
6J57_A        186 ---MTTPDSFe---------------------------fGGELATYL-----EGEK--VQSTPT-NDLVFSPEKLIEY-I 226 Corynebacteriu...
jgi:Daci_0212 179 asrLLPRESPrd-------------------------wsAQVCRLRV-----GAAP--LQAFTG-THPLGDPLWLLAGwL 225 Delftia acidov...
2WQT_Q        171 ---AQR-PAGld-------------------------lkNCAMKMTR-----NNEE--VSSGRG-SECLGHPLNAAVW-L 212 Escherichia co...
jgi:M446_2715 196 ---AVTPDELgpdw----------------------qdgMVQRPLCVt---rNGAL--LGRPEAgSDLGSGFGELIAE-A 244 Methylobacteri...
Q4J6Y6        222 ---IVTKDEVge-------------------------ikGLRAYASV-----DGEKwcDTKA---EDMQWSFEDMISY-V 264 Sulfolobus aci...
Q162G6        261 ---IVTKAALepfrastppreke---llpylaetgpmlyDIDLEVGLapegkSETI--LSRTNY-NVMYYSAAQQLTHhT 331 Roseobacter de...
CAK38680      242 ---IVPIEALegsqcnarvqdpaplkhlawkgkedeatfDIELKARVird-gksYT--VTETNL-KELYWTPYQQVTHlC 314 Aspergillus niger
WP_000674021  200 ---LVTKEELdvyrn--------------------gdryELEMTAHV-----NGKL--LSKGNF-QDIYYTFAEMIER-A 247 Bacillus
Q9CKS8        138 ---V-LKSAVqn-------------------------paELTINITV-----NGSV--KKSYVH-LAMKHSIPELISF-L 179 Pasteurella mu...
Q63MG5        138 ---IVARASIgd-------------------------adALAVTVRI-----DGER--RYEAST-ANLIRPVARLIAD-V 180 Burkholderia p...
6J57_A        227 THIY-----PLDAGDVIVTGTP-G-Gvg-----hA------------------------RNPQRYIGDGETVkveIa--- 267 Corynebacteriu...
jgi:Daci_0212 226 QELVrr-ygSVPAGTVVTTGTW--------------------------------------NGLAFAQAGDLVvaeLd--- 263 Delftia acidov...
2WQT_Q        213 ARKMaslgePLRTGDIILTGAL--------------------------------------GPMVAVNAGDRFeahIe--- 251 Escherichia co...
jgi:M446_2715 245 ARLR-----PLGAGTIVSAGPV-S-NrgidggpgrsvaeggagfaslaearaaeivasgWARLPYLAPGDRLrveVkdrg 317 Methylobacteri...
Q4J6Y6        265 SQDE-----YIRPGDIFGSGTI-SgC--------Cg-----------------------LDNGRLLRPGSLVelyIe--- 304 Sulfolobus aci...
Q162G6        332 TSGC-----PMRVGDLLGSGTI-S-Gp------eKenrgsllelsw---agkepltldtGETRTFLEDGDTLtlrGaakg 395 Roseobacter de...
CAK38680      315 SAGE-----GLSTGDIFGTGTI-T-S--------DvreeigvacllerklernilseasKDGLDFLADRDEV---Imegw 376 Aspergillus niger
WP_000674021  248 SEDV-----TLYPGDVIGSGTVgT-G--------Cil---------------------eLGTEEWLQDGDVVeltIt--- 289 Bacillus
Q9CKS8        180 SQFI-----AFKAGDILLTGTE--------------------------------------DMPLLVGAGDQVsveFa--- 213 Pasteurella mu...
Q63MG5        181 SAFM-----SFDAGDVLLVGVG--------------------------------------PHAPRAAAGSTIeidAp--- 214 Burkholderia p...
6J57_A        268 ----------gLGFIENK 275 Corynebacterium glutamicum
jgi:Daci_0212 264 ------------GIAEAR 269 Delftia acidovorans SPH-1
2WQT_Q        252 ----------gIGSVAAT 259 Escherichia coli K-12
jgi:M446_2715 318 -------ghsvFGAIEHE 328 Methylobacterium sp. 4-46
Q4J6Y6        305 ----------kIGILVNR 312 Sulfolobus acidocaldarius
Q162G6        396 d-----gyrigFGDCTGT 408 Roseobacter denitrificans OCh 114
CAK38680      377 cvnrltggkfgFGECRSV 394 Aspergillus niger
WP_000674021  290 ----------gLGTLRNT 297 Bacillus
Q9CKS8        214 ----------qLGCLTNT 221 Pasteurella multocida
Q63MG5        215 ----------gIGTLRHT 222 Burkholderia pseudomallei
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