Conserved Protein Domain Family
DDE_Tnp_Tn3

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pfam01526: DDE_Tnp_Tn3 
Tn3 transposase DDE domain
This family includes transposases of Tn3, Tn21, Tn1721, Tn2501, Tn3926 transposons from E-coli. The specific binding of the Tn3 transposase to DNA has been demonstrated. Sequence analysis has suggested that the invariant triad of Asp689, Asp765, Glu895 (numbering as in Tn3) may correspond to the D-D-35-E motif previously implicated in the catalysis of numerous transposases.
Statistics
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PSSM-Id: 426307
Aligned: 88 rows
Threshold Bit Score: 379.545
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
jgi:Psed_6707  618 DLLFEVHSWTGFLDSFRHVSDRRTRMegLLVSLVALLVSQSCNIGLTPVIDpQSKALTRSRLSHVDQNYLRADTIAAANA 697 
CCU72108       591 DVIINVEKWLNLNKHFGPLSGFESRIsdPVLRFVLTVFCYGTNIGPTETVR-SVQGVSRKQVAWLNLKRTTEARLDKAIA 669 
WP_013262432   594 DLLVDTVKWVPMKNLFGPLSGLQSKLrnYDKRLVASLFCYGCNLGPAQTAR-SLKGFSRRQIALLNLEHIHEQNLEEAIK 672  gamma proteo...
Q12AQ3         568 DLLLEMDAHTNFSEIL---LARRATDesELVALYAALIAHGTEIDAKSVAA-MTPQLDPDQVSVAMRALEASGRLRRANE 643  Polaromonas ...
Q7WXI9         569 DLLLEVDASTNFSEVL---LGHRAKSvpELLSTYAALLAHGTEIDAKGIAA-MIPGIDTAQVSLAMRGLETHGRLRRANE 644  Cupriavidus ...
jgi:Ajs_1323   579 DMLLEVDAATGYSEAL---LGHRAQStgELVALYGALLAHGTDADAKGVAS-MIPGLEPTQVTVAMRALEGSGRLRRANE 654 
jgi:Swit_5075  568 DLLISIDATTHFSWVL---LGRAPRSehELILLYAALIALGSDLTAADMAR-MTLNIEADAVGEMMRRIEANGRLPAANR 643 
WP_008209282   567 gVMMEVDSHTRFSWTL---LGREPRSidELRLVYAGLLAHGTALSAADTAR-MMPGLSADAVNQSMRWIAQEKRLREANT 642  Rhodanobacter
CAP44109        29 EVILAVDAQVRFSWIM---LGREPRStdELLMVYAGIMAHGTSLTAVECAR-MIPQLSATSIRQAMRWARDERRLSQACQ 104 
jgi:Bphy_7306  566 rIILEIDSAARFSWVL---LGREPRSraELLMTYAAVLAHGTSMSAADIAR-MVPELSASAIRQMMNRIADERMLRQAAD 641 
jgi:Psed_6707  698 ALITAQSAIELAQMWGGGLLASVDGLRFVVPVKSINTGPSPKYyGykRGVTWLNAVNDQVAGIGAMVVRGTPRDSLYTLD 777 
CCU72108       670 KINSEYKKYRLIECWGSGNSVSADGKLWDLYEDNLLSEYHIRYgS--YGGIAYYHVSDTYIALFSRFIPCGVYEAIYILD 747 
WP_013262432   673 RVVNTYNQYELPGYWGTGDTASVDGTHFDMYDQNLLSEYHIRYaS--YGGIGYYVVSDKYIALCSRFISCGVREAFHLID 750  gamma proteo...
Q12AQ3         644 RVVEFQGKHAIAELWGSGKTASSDMMSLDASKHLWNARVDPRRrT--HAAGMYTHVLDQHGIVYDQPIVLNERQAGPAIE 721  Polaromonas ...
Q7WXI9         645 VVAEFQGKIPLATNWGTGQKASADMMSLDVSRHLWIARVDPRRrT--YATGIYTHVLDKWGIVYDQPIVLNERQAGVAIE 722  Cupriavidus ...
jgi:Ajs_1323   655 RVAEFQSRIPIAALWGNGDKASADMMSLDVSRHLWNARVDPRRrT--YAAGLYTHVRDRWGIVYDQPIVLNERQAGVAIE 732 
jgi:Swit_5075  644 VVLDHFRTLPVTRLWGGGLQASADMMSLDATRRLWTARYDPRRrT--PAVGTYTHVLDQWVILHDQAVVLNRRQAGAAIE 721 
WP_008209282   643 AVFEYMHSHPIAESWGRADLASADMMSRETVKSSPLARRDPRTkK--KSIGIYTHIHDRWGIFHDQPVVLGERQQGVALE 720  Rhodanobacter
CAP44109       105 AVLEFMQRHPIAATWGRSDLASSDMMTMETTKRVWQARLDPRRnT--PSIGIYSHVKDRWGIFHAQPFVLNERQAGVAIE 182 
jgi:Bphy_7306  642 AVLEFMHFHPIAQHWGRADLASSDMVSLETTRTVWQARADPRRrT--ASIGVYTHVRDRWGIFYDQPILLNERQAGVAIE 719 
jgi:Psed_6707  778 TLLNLDGG---VKPEMVATDNASYSDMAFGLYKMLGFRFAPRFRDLSDQRFWRADLPDGegpaagYGPLEAVAC-NKVNL 853 
CCU72108       748 GLLNDESD---FNPDTVHGDTQAQSTPVFGLAYLLGIKLMPRIRNIKDLSFYKPDRAMV------LKHIQSLFK-EPIKW 817 
WP_013262432   751 CLMENTSD---IQPHTVHGDTHAQSTVVFGLASLLGIKLMPRIKDVNSLVFFKPDRRIR------YDHIDDLFG-EGIDF 820  gamma proteo...
Q12AQ3         722 GVVRYNDSterVRLSLLAVDTHGYTNPAMAISKLLEFDLCPRLRDLSERKLFLPRSLEA------PEGLDQVLVrD-VSL 794  Polaromonas ...
Q7WXI9         723 GVEQHNRCedrIRLSLLAVDTHGYTNAAMAWAKGLSFDLCPRLRDLSERKLYLPAEFKV------PEGIERVTTkR-LSL 795  Cupriavidus ...
jgi:Ajs_1323   733 GIEQHNSAadrIRISLLAVDTHGYTNPAMAISKLLGFDLCPRLRDLAERKLYLPRGFTV------PDGLEVVTVrR-VSL 805 
jgi:Swit_5075  722 GALRHES----VDLHRVAVDTHGHTHFGMALANLVGFDLAPRLAGMNKRKLYLPRGLNI------PATLRPIVSeT-VSL 790 
WP_008209282   721 GVLRQST----VTINQLAVDTHGQTEFGMFLAKTVGKDMCPRLRDASAHKLYVTPAMTV------PEGLRSVIAkNRAHP 790  Rhodanobacter
CAP44109       183 GVIRQEK----LETSQLAVDTHGYTDFAMSHARLLGFDLCPRLKELKQRHLFVPRGTKV------PAEIAAVCEaN-VDV 251 
jgi:Bphy_7306  720 GVIRQNST---DDVTLLAVDTHGYTDFAMGLARALGFDLCPRLAHLRDRRLHVPVAHAI------PAGLLPVVDrD-VKL 789 
jgi:Psed_6707  854 KRIATHWPDMLRVAGSLITNQVRAYDLLRMFGREGHPTPLGAAFAEYGRIDKTMHLLALVDpvDDTYRRLMNRQLTVQES 933 
CCU72108       818 DLIEKHYADMMRTAMSVKAGKITASTILRRFGTKNRKNKLYFAFRELGRVVRTMFLLEYIT--DVDLRKTIQAATCKSEE 895 
WP_013262432   821 NLIKNHLRDMLRVALSIKLGKVSASTIIRRLGTEGIRNQLFYAFRELGRCMRTMFLLEYIT--DIEMRETINAATCKSEE 898  gamma proteo...
Q12AQ3         795 KAITKGWDELLRLAASIRSGRVSANVALQRFGSAAQGDPVHKAADQLGRLLRTLFLCDYFS--NPEFRREIHTILNRGES 872  Polaromonas ...
Q7WXI9         796 RAIRLGWDDFLRVLASIRIGRISAELAMQRLGSAARTNRAHKAAEHLGRLLRSIFLCDYVT--IEDFRREIHTLLSRGES 873  Cupriavidus ...
jgi:Ajs_1323   806 AAIERGWDELLRLAASIRSGRVSATLALQRFGSAAQGDPLHRAAEHLGRLLRTVFLCDYIA--IEDFRREIHTLLNRGES 883 
jgi:Swit_5075  791 SAITQGWDPLLRIAASTKSGWCSATYVLDRFGSAARGDEAFQAGDAFGKLLLTRFLGAYLG--DPAFRGMNDALLSQGES 868 
WP_008209282   791 EKVEPVWDEWVRMAASTHVGKASAVDILSRFGSAAAGEQLYDAGVQIGRLLLTLYLCRWFT--LPDFRREILRTLNHGER 868  Rhodanobacter
CAP44109       252 ALIEKHWDSLVHLAASVMSGHASAVAALARFGSAAQGDPIYEAGVQLGRLLRTAFLADYFV--KDAFRNELRRVLNRGEA 329 
jgi:Bphy_7306  790 EAIEAVWDEFVRVAASVQSGHCTAVQALTRFGSAARGQPLYEGGVQLGRLFRSIFLIDYFT--VPAFRSELQHALNRGEA 867 
jgi:Psed_6707  934 RHRLARAICHGGRGQIRQAYREGQEDQLAALGLVLNAVVLWNTRYLDAAVAQLRAE-GHDIKDEDVARLSPLKDRHINFL 1012
CCU72108       896 FNEFARWLFFANAGKIPANLKHEQSKIVKYNHLLANFTILYNVNAMTEVFNQLKSE-GHNITRDLMAAFSPYHTEHLGRL 974 
WP_013262432   899 FNQFLQWVFFYDKGIIQENLRAEQAKLIKYNHLVANLVVLHNVNAMTRAFRKLKRE-GHQVTPDLLKLFSPFRGEHINRL 977  gamma proteo...
Q12AQ3         873 VHQLQRAVYFGKVASERGRRRDEMIAISGSHTLLTNLVLAWNTHHMQETADRWRRT-GQKLEDTWLARMGPAHFANVNFR 951  Polaromonas ...
Q7WXI9         874 VHQLQRAIHAGRVPHERGRRGDEMTAISGAHALLTNIVLAWNTHRMNDVVERLRKG-GTNIEDAWLRRMGPGHSGHINFR 952  Cupriavidus ...
jgi:Ajs_1323   884 VHQLQRAVYSGKVAPERGRRRDEMKAISGSHALLTNIVLAWNTARMHEVVERLKRD-GIPVEDYWLRRIGPAHFSHINFR 962 
jgi:Swit_5075  869 VHTLQRAIYSGPIGARHGRTPEQMAAISSGLTLLTNVIMTWNATRIGEVRARMPD----IFPDHHIKHIAPNAHEHINTK 944 
WP_008209282   869 VHVLEHALETGKVPRHQMSHNARLRSVSSAITLLSNIVMAWTTARMQQSLATLPADiAALAVPENLRHIAPIQERLVNFR 948  Rhodanobacter
CAP44109       330 VNALKRAIYTGRISPAQAKRVDEMQAVADALSLMANIVMAWNTSQMQAVLDRWSNR-RQVIPPELIGKIAPTRLESINLR 408 
jgi:Bphy_7306  868 VHNVQRAIHQGKIPVELTRHRHSMIAVSSALTLLTNAVMAWNTHHMQRALDMIEQLgAQPVEAHHLRSIAPTSLEGINLR 947 
jgi:Psed_6707 1013 GRY 1015
CCU72108       975 GSF 977 
WP_013262432   978 GSY 980  gamma proteobacterium HdN1
Q12AQ3         952 GTF 954  Polaromonas sp. JS666
Q7WXI9         953 Gil 955  Cupriavidus necator
jgi:Ajs_1323   963 GTm 965 
jgi:Swit_5075  945 Gvi 947 
WP_008209282   949 GLF 951  Rhodanobacter
CAP44109       409 GVF 411 
jgi:Bphy_7306  948 GTF 950 
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