5E3T


Conserved Protein Domain Family
PIP5K
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pfam01504: PIP5K 
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Phosphatidylinositol-4-phosphate 5-Kinase
This family contains a region from the common kinase core found in the type I phosphatidylinositol-4-phosphate 5-kinase (PIP5K) family as described in. The family consists of various type I, II and III PIP5K enzymes. PIP5K catalyzes the formation of phosphoinositol-4,5-bisphosphate via the phosphorylation of phosphatidylinositol-4-phosphate a precursor in the phosphinositide signaling pathway.
Links
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Statistics
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PSSM-Id: 426295
Aligned: 333 rows
Threshold Bit Score: 106.909
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5E3T_A         87 LCNEPLIELSNPGAS-GSLFYVSSDDEFIIKTVQHK-EAEFLQT-LLPGYFMNLNQNMRTLLPKFYGLYCVQadGKNI-- 161  zebrafish
CAM71964      794 detTAWRITVSPGKSgTTLLYFSD---FVMKTVRPR-EMEFLLRkFLPAYVRYCERNPHTLLPRFYALATLrwwka---- 865  Leishmania in...
Q4DKY9        721 GENAMWRQSISPGKSgTSFIFFGN---FVLKSLKES-EFKFLKNrFLRSYVSFCELNPDTMLPRFYALLSFswlrl---- 792  Trypanosoma c...
EMC94624       25 eSEDALVSMGDMGFS-GSTFFRTSDGRYLVKSVPRQfEYSFFKDdLLRPYADYMQRTETSLLVRITDFLQP---VSHTig 100  Baudoinia pan...
XP_003852848   75 dgnSKLQAMEDMGFS-GSTFFTTEDTAYIVKSVPRHfEHSFFKNdFLIPYVQHVHNNSGSLLIRTTEFLAN---KHFTig 150  Zymoseptoria ...
XP_007920148   72 kkkrDLKPMGDMGYS-GSTFFTTSDSSYIVKSIPRHfEHSFFKNdLLLPYAEYMQNNPSSLLTRITDLLEC---CQVSig 147  Pseudocercosp...
XP_001568671  114 PEDCLRMEL-GEGRS-QAFFLKSKTMAFMCKTISVE-EVRVLLD-ILHAYMQHIAAHPGSLLMRFYMLLKVSv-RKEK-- 186  Leishmania br...
Q4Q241        114 PENRLKMEM-GEGRS-QALFLKSKTMLLMCKTISVE-EVHALLH-VLRAYTLHITAHPSSLLMRFYMLLKVSv-RSEE-- 186  Leishmania major
Q38BC4        121 pnerqDLEL-SEGRS-MALFLESKSKYLLCKIIAKV-EVDVLLH-LLPRYAKHFREHSNTLLMRFYMLLRVEf-RGEL-- 193  Trypanosoma b...
Q4D5N5        121 peDRLALEL-GEGRS-MALFLKSKSMDLMCKTIAEE-EVNVLLK-LLPQYTEHLSRNTNTLLMRFSMLLRIEa-GAEV-- 193  Trypanosoma c...

5E3T_A        162 --------RIVVMNN-LLP------RAVP-MH---LKFDLKGSTYKRRASPKERSKGV---------------------- 200  zebrafish
CAM71964      866 ----gvvqHFVLMQN-VFA------TPYY-IH---RIYDVKGSTVNRTAL-QPGKPPPrt-------------------- 909  Leishmania in...
Q4DKY9        793 ----rsckRYVLMQN-VFF------TRYY-IH---RIYDVKGSTVGRSTK---TETAPrt-------------------- 834  Trypanosoma c...
EMC94624      101 talgtapsHQLVMEN-ILYgqdkhdEQDhegKqkwESWDLKPMSYF---------------------------------- 145  Baudoinia pan...
XP_003852848  151 qilqlaptHHIAMEN-LLYqqgk---------nhwETYDLKPMSYF---------------------------------- 186  Zymoseptoria ...
XP_007920148  148 ticglapsHHIVMEN-LLYg----------kEdswEDYDLKPQSYF---------------------------------- 182  Pseudocercosp...
XP_001568671  187 --------GYILCFNdIFA------AASV-LH---EKWDIKG----RIPKPGKSLRNPdflrrgselnlhlieaqkkrng 244  Leishmania br...
Q4Q241        187 --------GYILCFNdVFG------TASV-LH---EKWDIKG----RVPKNGKHLHYPhligsgyepdphatkpppkrhv 244  Leishmania major
Q38BC4        194 --------GYVLCFGdVFA------PCRT-LN---EKWDLKG----RRPKPGKYKHFAklfqhpydsttgqstt-----p 246  Trypanosoma b...
Q4D5N5        194 --------GFILCFGdVFA------PCRT-LN---EKWDLKG----RIPKPGKYQHFPkliqrpyepnpyliet------ 245  Trypanosoma c...

5E3T_A        201 ---------------PT---------------YKDLDFMQDMpe--------------gILL-ENDHYTALSRTMQRDCR 235  zebrafish
CAM71964      910 --------------aFGal------------lLKDNDLPPQ------------------LIIcGTYQRAIVLAQLRSDVG 945  Leishmania in...
Q4DKY9        835 --------------sYGal------------lLKDNDLPAQ------------------LIIcGPLQRAHVLAQFRSDVN 870  Trypanosoma c...
EMC94624      146 --------------------------------YPERDVAGGAltsdetkskladefhdkLVL-SLDDAEDFKAQLEKDTK 192  Baudoinia pan...
XP_003852848  187 --------------------------------YPERDIAGGAltseetkskladkfkdkLLL-TLDQAEALKYQLEKDTS 233  Zymoseptoria ...
XP_007920148  183 --------------------------------YPERDVAGGVltseatkskladdynekIVL-TLDEAEDLKGQLEKDTK 229  Pseudocercosp...
XP_001568671  245 ivkpvtdaseqlynrEDgvvvkeakgaqspptLHDKDLTRL------------------FLL-PQNTRKRLLEQLLRDYD 305  Leishmania br...
Q4Q241        245 lanpaidasqqhpgrESavvvrgtkdaqglptLHDKDLTRL------------------FWV-PRTARKRLVEELLRDYD 305  Leishmania major
Q38BC4        247 gtdttqyfpsgtgisGLkempkat-dknklatKKDKDLTRY------------------FWL-DKEQREKLLLTLRDDCK 306  Trypanosoma b...
Q4D5N5        246 prdtievpelvgsqeERvvvveaa-dkdklatRKDKDLTRL------------------FWL-ERHERNKLIRALMKDYE 305  Trypanosoma c...

5E3T_A        236 VLQSFKIMDYSLLV--------------------------------GI-------------HILHRAGEEASTAVPDTQK 270  zebrafish
CAM71964      946 FLRQLNVVDYSCMI--------------------------------GVrsrlfsseegpskTLLLLRRQHHDGHVSTLGS 993  Leishmania in...
Q4DKY9        871 FLQSLNIVDYSCLI--------------------------------GVrsrvfsrkegpskTIVLKERRGSSWQQTVTSE 918  Trypanosoma c...
EMC94624      193 LLADCNAVDYSLFLvripieateggaapp--peppfappsppswrtGV--------------SSA--------------- 241  Baudoinia pan...
XP_003852848  234 LLATCNAVDYSLFLvripiteapnpfddpqlnatpllppdppsfrtGM--------------PST--------------- 284  Zymoseptoria ...
XP_007920148  230 LLADCNAVDYSLMLvripvsdapgqeelpaksktplvppappswrtGV--------------KSA--------------- 280  Pseudocercosp...
XP_001568671  306 FLNSAGMMDYSLLI--------------------------------GV-------------TYHENKAPQSGRHCISDRM 340  Leishmania br...
Q4Q241        306 FLKNAGMMDYSLLI--------------------------------GV-------------AYQDDKTRPSDKHCGIEST 340  Leishmania major
Q38BC4        307 FLASVGLMDYSLLI--------------------------------GV-------------AYEEKGISNPTKRLRSMRM 341  Trypanosoma b...
Q4D5N5        306 FLGNAGMMDYSLLI--------------------------------GV-------------AYNETKVSRSGKLVRSMRM 340  Trypanosoma c...

5E3T_A        271 KGQGQKPLYCTAI---------------------------------------ESIQGESKSKTSPQPYESMGGIPAFNSK 311  zebrafish
CAM71964      994 SAVATQGHIGQTCsevmyatdktaaadgagisvgameptlppfsvdaqrsdcDDDVYVCIHGCDGGLLSLPIHTSGDDTT 1073 Leishmania in...
Q4DKY9        919 AIGVGTEQLHK-------------------------------------------MDNSCIHGCDGGLLSLPIYSAGDDTT 955  Trypanosoma c...
EMC94624          --------------------------------------------------------------------------------      Baudoinia pan...
XP_003852848      --------------------------------------------------------------------------------      Zymoseptoria ...
XP_007920148      --------------------------------------------------------------------------------      Pseudocercosp...
XP_001568671  341 SNSAQHDAASASSwaev-------------------------------rpapLAKDSHLSDKKTSHSVTPPEFANGVRSV 389  Leishmania br...
Q4Q241        341 NVTSSSAVAPASTsaea--------------------------------rpaSLAQDSHPSGTRTMLTTVPEFANGVRSF 388  Leishmania major
Q38BC4        342 PYPRCGPPEG---------------------------------------------AMENRPEWTMTCGGECKFSKGIFSL 376  Trypanosoma b...
Q4D5N5        341 TYPMGSERDAD-------------------------------------------LAEVRPASLPRRCPTPHDFRAGITSL 377  Trypanosoma c...

5E3T_A        312 GERLLVFIGIIDILQSYRLVKKLEHSWKALl-------HDGDTVSVHRPSFYADRFQKFMCST 367  zebrafish
CAM71964     1074 AREEVYYLGIIDVLQTYNSVKKLESFAKGFvn-----dRRA--ISVIAPDKYAERLYKVLERI 1129 Leishmania infantum JPCM5
Q4DKY9        956 AREDVYYLGIIDVLQEYTPAKRFENFAKGLwn-----dRRH--ISVVPPKEFAERLYKVLENI 1011 Trypanosoma cruzi
EMC94624      242 DGNYAYRAAVLDF--FWAKHKTQALAMTGLinaynavdRQGPMSITTDAPEYRQRFLAMCNEf 302  Baudoinia panamericana UAMH 10762
XP_003852848  285 DGRWVYRAAVLDF--FWAKHKAHAKAMSLLinaynifdRKGPMSVTTNSPEYRQRFLNMIYDM 345  Zymoseptoria tritici IPO323
XP_007920148  281 DGKWVYRAAVLDF--FWAKHKVHAKAMTGLintynavdGQGPMSVTTDSPEYRTRFLKMVEDM 341  Pseudocercospora fijiensis CIR...
XP_001568671  390 CEQEIYYVGIIDVLTAYTIKKKGANFFKSFlw-----eQNM--LSTIPPDYYARRLTSFTELI 445  Leishmania braziliensis MHOM/B...
Q4Q241        389 DGQEMYYIGVIDVLTTYTLKKKSANFFKSLlw-----kQKT--LSTIPPDRYAQRIASFTELI 444  Leishmania major
Q38BC4        377 YNQEVYYIGVIDVLTPYTFKKKLAKLFKSFlw-----rMDT--LSTIPPLKYCERILQFTEDI 432  Trypanosoma brucei
Q4D5N5        378 QDQEIYYIGIIDMLTKYTWKKKTANFFKKFlw-----kPET--LSTIPPVEYRKRISKYTKII 433  Trypanosoma cruzi
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