4GZA


Conserved Protein Domain Family
Sema

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pfam01403: Sema 
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Sema domain
The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and plexin-A3.
Statistics
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PSSM-Id: 426245
Aligned: 202 rows
Threshold Bit Score: 132.046
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4GZA_C          21 HLTVHRRTG---AVYVGAINRVYKL-TGNLTiqvaHkTGPEEDNKACYPPLIv-qPCsevlt-----ltnnVNKLLIIDY 90   house mouse
4_pfamImport     1 NFALDGPGS---RVYLAAVNRLFQLsGGELAleaeAaVGPVLDSPLCHAPQLpqaSCehprv-----ltnnYNKILQPDP 72  
22_pfamImport    1 TVKVADFG----------------L-ARDILe---KeYYSVQQHRHARLPVK----------------------WMALES 38  
Q07E01          54 NIVVHRD-----DLYLGAVNKIYVLd-KNLQdfveYpTGPVLEHPDCAPCE----NCsaiahsskadlrdnVNMALLIET 123  platypus
XP_004915612    50 NLVSFED-----SLFLTTTNHLYVLkGNELHllqnItTGP--TDSQCTLCS----KCqlgealp-kqpedtVSQVLAVDP 117  tropical cla...
XP_004186282    56 VFTDSDSPV---AAFVAVRNRILLV-SPELRllsvLiTGP-VGSAECEICR----LCpattd----gpedtDNVLLLLDP 122  zebra finch
XP_012398969    54 RVIAYGDGQ---VVFVATRNHLYMLs-ADLEllqsLvTGP-AGHPGCQSCA----ACnwsessl-pgtgdtDNAVLVLDP 123  Tasmanian devil
XP_009443794    57 amvTYEGDRnesAVFVAIRNRLHVLg-PDLKsvqsLaTGP-AGDPGCQTCA----ACgpgphg---ppgdtDTKVLVLDP 127  chimpanzee
Q62190          59 atAAYEDSTn-sAVFVATRNHLHVLg-PDLQfienLtTGP-IGNPGCQTCA----SCgpgphg---ppkdtDTLVLVMEP 128  house mouse
XP_013015359    83 TYEDGQDGS---AVFVATRNRLHVL-GPELQivqsLaTGP-AGDPSCQTCA----ACgpgphg---ppgdtDTLVLVLEP 150  domestic gui...
4GZA_C          91 SE--NRLLACGS-LYQGVCKLLRLDDlfilve---------pshkkEHYl----------------------SSVNKTGT 136  house mouse
4_pfamImport    73 EQ--GVLVVCGS-IYQGLCQLRSMANisavavrf----ppggsdsvAVFpsm-----------------lnvAANHPNAS 128 
22_pfamImport   39 LQ---------ThKFTTKSDVW---------------------------------------------------------- 51  
Q07E01         124 YYhyEQLIICGS-VDGGACWRFplpl----------------geptDFHskkhcmfshq---adeeskdcpdCIVSTLGT 183  platypus
XP_004915612   118 EE--SVIYSCGS-SLHGLCYMHii--------------------asSKIveseclfrqs----gnsasscpdCIASPLGT 170  tropical cla...
XP_004186282   123 LE--PWLYSCGT-AQHGLCYQHQLEVqdgkvaitathclysamdnsPAFcp--------------------dCVVSPLGT 179  zebra finch
XP_012398969   124 DQ--PWLYSCGS-SLLGRCFVHelds----------------qdrgPRLgrtsclwdps----anspqhcpdCIASPLGT 180  Tasmanian devil
XP_009443794   128 AL--PALVSCGS-SLQGRCFLHdlep----------------qgtaVHLaapaclfsah----hnrpddcpdCVASPLGT 184  chimpanzee
Q62190         129 GL--PALVSCGS-TLQGRCFLHelep----------------rgkaLHLaapaclfsan----nnkpeactdCVASPLGT 185  house mouse
XP_013015359   151 GL--PALVSCGS-SLQGRCFLHELEP--------------------HGTalhlaapaclfsadrnlpedcpdCVASSLGT 207  domestic gui...
4GZA_C         137 MYGVIvrsegeD-GKLFIGTAVD-Gkq---------------dyFPTLSSRKlp-----rdPESsAMLdyelhsdfvssl 194  house mouse
4_pfamImport   129 TVGLVlrrgggGgARLLVAATYT-GfgspffprnhsledhrfenTPEIAIRAln-----arGDLaKLFtfdinpsddni- 201 
22_pfamImport   52 SFGVLl---------------------------------------WELMTRG---------ASP---------------- 67  
Q07E01         184 KVLLVek---dRfVNFFVGNTInsssh-------------pfssLHSISVRRlk-----etLDGfkfltdqsyi------ 236  platypus
XP_004915612   171 LLSVVtq---sRgVYFYTASSLdsria-------------esysPTSISIRRll-----gsQDGfspgfhsls------- 222  tropical cla...
XP_004186282   180 SATVVat---sYaSVFYLGSTInssva-------------arysPQSVSIRRlkgtldgfsNDFqWLTvlpqy------- 236  zebra finch
XP_012398969   181 RVTVVpl---gYsSYFYVASTLnqtva-------------srysPHSVSIRRlk-----snLRGfapsspals------- 232  Tasmanian devil
XP_009443794   185 RVTVVeq---gQaSYFYVASSLdaava-------------asfsPRSVSIRRlk-----adASGfapgfvals------- 236  chimpanzee
Q62190         186 RVTVVeq---gHaSYFYVASSLdpela-------------asfsPRSVSIRRlk-----sdTSGfqpgfpsls------- 237  house mouse
XP_013015359   208 RVTVVeq---gQaSYLYVASSLnaTvaasf-----------sprsVSIRRLR---------ADAsGFEpgfaalsv---- 260  domestic gui...
4GZA_C         195 ikipsdtlalvshfDIFYIYGFASGGF--------VYFLTVQP---ETP-DGmainsAGdl-fyTSRIVRLCKDDPK--- 258  house mouse
4_pfamImport   202 ---lkikqgdkarhKLSFVRAFLQHGAapparrpyAYLALNTE---ANAgDKe---sPA-----HSLLARICLGEPAeat 267 
22_pfamImport   68 ------------------------------------------------------------------------YPDIDp-- 73  
Q07E01         237 ----dvlpqfrdsyPIKYIHAFESNQF--------IYFLTVQKetvEsq-------------tfHTRIIRFCSMDSE--- 288  platypus
XP_004915612   223 -----vlesyrdsyPIHYVHTFVSGSY--------VYFLTVQPehpLsn-------------tyHSRVVRLSKNEEE--- 273  tropical cla...
XP_004186282   237 ----------rnnyTIHYVHSFADGDH--------VYFLMVQP---ERPgSAv-----Y-----HTRLARLGTHERD--- 282  zebra finch
XP_012398969   233 -----vrpgylatyPIEYVYTFHSGGH--------VYFLTVQPeslKvpt------------tfHTRLVRLSATEPD--- 284  Tasmanian devil
XP_009443794   237 -----vlpkhlvsySIEYVHSFHTGAF--------VYFLTVQPasvT-----------DdpsalHTRLARLSATEPE--- 289  chimpanzee
Q62190         238 -----vlpkylasyLIKYVYSFHSGDF--------VYFLTVQPisvT-----------SppsalHTRLVRLNAVEPE--- 290  house mouse
XP_013015359   261 ------lpkyldsyHIEYVHSFHSGAF--------VYFLTVQP---ASVtDTpg---aL-----QTRLVRLNALEPE--- 312  domestic gui...
4GZA_C         259 ----------FHSYVSLPFGCT-------------RAGVE-------YRLLqaaylakpgeALAQAFNissdeDVLFAIF 308  house mouse
4_pfamImport   268 lngsgetkklTESYIQLGLRCG-------------GAADA-------FTRL----------VSVFPAR-----ELLFGVF 312 
22_pfamImport   74 -----------------------------------------------F-------------------------------- 74  
Q07E01         289 ----------LHSYMEMPLECIltek------rrrRSTNKe-----vFNVLqaayvskpgaHLARQIGtglndDILYGVF 347  platypus
XP_004915612   274 ----------MRSYRELILECRlepk------rrrRRRRAep---kiFNVLkaahvatvgsTLAGELDisekdPVLFAVF 334  tropical cla...
XP_004186282   283 ----------LRHYRELVLDCRfeskrrrrrsgeeDAERDi-----aYNVLqaahaarpgaRLARDLGinhtdTVLFGAF 347  zebra finch
XP_012398969   285 ----------VGEYRELVLDCHfsnk------rrrRRRQGvsleketYNVLqaahvarvesSLAEGLGvpegqKVLFGAF 348  Tasmanian devil
XP_009443794   290 ----------LGDYRELVLDCRfapk------rrrRGAPEgg---qpYPVLrvahsapvgaQLATELSiaegqEVLFGVF 350  chimpanzee
Q62190         291 ----------IGDYRELVLDCHfapk------rrrRGAPEgt---qpYPVLqaahsapvdaKLAVELSisegqEVLFGVF 351  house mouse
XP_013015359   313 ----------LDDYRELILDCDfap-------krrRRAPEgr---hsYPVLqaahsahvgaQFASELNiaeghEVLFGAF 372  domestic gui...
4GZA_C         309 SKgqkQyhhpPDDSALCAFPIRAINLQIkerlqscyhgegnl------------------elnwllgkdvqctkAPVPid 370  house mouse
4_pfamImport   313 ERagpAggrgRPQSALCVFRFAEIEETIraarnscfvspaagmvtvldsvvqgtgpacekrniqlqpeqldcgaAHLQ-- 390 
22_pfamImport   75 ----------------------DIMHYLargrrlpqp-----------------------------eycphslyKVMG-- 101 
Q07E01         348 AQskpDsaepMNRSAICAFPIKYINEFFskivnknnvrclq---------------------hfygnhhrhcanRTFQwn 406  platypus
XP_004915612   335 AQsepKsaqpRYNSAVCAFPLRLIDLSIedgmnaccsntnsvrl-----------------trglnffqpemdcpqKDnq 397  tropical cla...
XP_004186282   348 AEsrpEsrvpQENSAVCAFPLRLLNQAMeegmekccgtghqpll--------------rglsffqpveycphnvNLSApv 413  zebra finch
XP_012398969   349 AVsreGsrlpRPKSAVCAFSISKLDELIdngmerccgspaqqerl------------ergveffqpqsycpdppQTIFld 416  Tasmanian devil
XP_009443794   351 VTgkdGgpgvGPNSVVCAFPIDLLDTLIdegverccespvhpglr-------------rgldffqspsfcpnppGLEAls 417  chimpanzee
Q62190         352 VTvkdGgsgmGPNSVVCAFPIYHLNILIeegveycchssnsssll------------srgldffqtpsfcpnppGGEAsg 419  house mouse
XP_013015359   373 VTgraGdsgmGPNSVVCAFPIDQLNTLIgegverccgssvisgp---------------rrgleffqtlsfcpnLPFPea 437  domestic gui...
4GZA_C         371 -dNFCGl-dINqplgGStpveglTLYTTSr--dRLTSVASYvynGYSVVFVGTKSGKLKKIrADGPphggVQYEMVSVFK 446  house mouse
4_pfamImport   391 --HPLAi--VNpv-tAT------PIFTHS----GLTAVAVAsvnNYTVVFLGTASGGLLKI-NLDStmkvISRRSILVAY 454 
22_pfamImport  102 ---QCW---VPas-tER------PSFRDLa--gELERISASlr-------------geHYVnLNGG------YVNLELSP 147 
Q07E01         407 ssGCEVr-dDEyrmeFTtplqrvDLSMGKfshvLLTSISTFikgNLTVANLGTAEGRFMQVvISRSdp-pSPHVDFLLD- 483  platypus
XP_004915612   398 sdTSCK----NvptlVLpplrrvDIFNGQldgvLLTSVYVSpqeDLTIGFLGTSAGRLLQVvLQRNsn-pRTLSNFSISd 472  tropical cla...
XP_004186282   414 vnTSCWdqpTLxpaaSHk----vDLFNGQltgvLLTSLFVTamgdVTVAHLGTAEGRIFQMvLQRSssylLTLSNFSLGE 489  zebra finch
XP_012398969   417 pnVSC----WNyptmIPtnypreDLLNGHldnvLLTAIHVIhqgNATVAHMGTADGRILQVkLFRSlnylLYVSNFSLGs 492  Tasmanian devil
XP_009443794   418 pnTSCR----HfpllVSssfsrvDLFNGLlgpvQVTALYVTrldNVTVAHMGTMDGRILQVeLVRSlnylLYVSNFSLGD 493  chimpanzee
Q62190         420 psSRCH----YfplmVHasftrvDLFNGLlgsvKVTALHVTrlgNVTVAHMGTVDGRVLQVeIARSlnylLYVSNFSLGS 495  house mouse
XP_013015359   438 psPNISchyFPllvsGSfs--rvDLFNGLlgpaQITALYVTrfdNVTVAHMGTADGRILQVeLARSlnylLYVSNFSLGS 515  domestic gui...
4GZA_C         447 dGSPILRDMAFS 458  house mouse
4_pfamImport   455 -GEPVHPIMQFD 465 
22_pfamImport  148 -----------L 148 
Q07E01         484 -NHPVSPEVIVV 494  platypus
XP_004915612   473 -NYPVSREVTQI 483  tropical clawed frog
XP_004186282   490 -PGPVRGAMGLQ 500  zebra finch
XP_012398969   493 -SQPVHREVSCL 503  Tasmanian devil
XP_009443794   494 sGQPVQRDVSRL 505  chimpanzee
Q62190         496 sGQPVHRDVSRL 507  house mouse
XP_013015359   516 sGQPIRRDVSRL 527  domestic guinea pig
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