5AMB,6S1Y


Conserved Protein Domain Family
Peptidase_M2

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pfam01401: Peptidase_M2 
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Angiotensin-converting enzyme
Members of this family are dipeptidyl carboxydipeptidases (cleave carboxyl dipeptides) and most notably convert angiotensin I to angiotensin II. Many members of this family contain a tandem duplication of the 600 amino acid peptidase domain, both of these are catalytically active. Most members are secreted membrane bound ectoenzymes.
Statistics
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PSSM-Id: 426243
Aligned: 58 rows
Threshold Bit Score: 737.464
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5AMB_A                  11 SADEAGAQLFAQSYQSSAEQVLFQSVAASWAHDTNITAENARRQEEAALLSQEFAEAWGQKAKElYEpiWQQFT-DPQLR 89   human
13_pfamImport            1 PSPDEIVKLFLADFDRRADQEFPGLMEKQWTYYTNLTEENRQIKVEAKIRITEFDSESRRTAQT-YYhtYPSHQiSYDVR 79  
PDM63802               307 VKDESEAREWMKGYAEEARKMLHLVTKSGWMYFTDASPTLNRALNEAEEVMARFVRATAQQAKQ-FD--TSAFA-DEALK 382  Pris...
PRJNA194094:J421_0092   42 TPTAAAARLFVDSVERRLDALSVTVNQAEWVAATYITDDTEALSADAQQRYDAAAQRFALAARR-FD----GVTvPPDLR 116  Gemm...
ASGPB:GKIL_2224         33 VQSVAEAQKFMQRAEGELAELNVKANRASWVGATYITDDTEALSADAQTNLNSAIQRFAIEAKR-FD----NLQmPPELA 107  Gloe...
WP_012048875            42 APTTAEADAFVADAEKQLADLGIYGAQVAWINATYITDDTDAVNARVGAEFTEMQVRYASGAAR-FD--GLKGL-SYDTR 117  Sphi...
BAK67040                32 APDSAQADAFVAAAEKEAFDYSVDASRIMWVNATHITDDTDALAAQAGAKGTEMAVRFALEAAK-YE--QVPGL-SFDTK 107  Sphi...
WP_015456931            30 APTAADADRFVAAAEKELFDLSIPTAQVAWVNATYITDDTDALNTLFGAKNTEASVRLAKEAAR-YD--KVAGF-SFDTR 105  Sphi...
Q8EE93                  43 TPDKAQAIAFIQDAEAQMAQLSIEANRAEWIYSNFITEDTAALSAAVGEKVSAASVKFATEAAK-YA----NVElDPANA 117  Shew...
WP_013051597            36 SSKTSEAKQFLIQSEQTLSDLSIEINRAEWIYSNFITDDTAALSASAAEKLTATSVRLATQAAQ-YT----DLAlDDTSL 110  Shew...
5AMB_A                  90 RIIGAVRTLGSa-NLPLA-KRQQYNALLSQMSRIYSTAKVCL------PQKT---ATCWSLDP----------------- 141  human
13_pfamImport           80 RELEAIASTSGspTYVDE-VTQELEDVKSRMEQRYHTAKVCR------KKGRrarKECLRLDPgleedcalvfkkrrcvi 152 
PDM63802               383 KQFGYVTFEGMs-TLNVA-DAEAFSTANSNMNKMAADVTVCD------LDLP---PPCALKKI----------------- 434  Pris...
PRJNA194094:J421_0092  117 RKLTLLKLAFTapPPSDPaKGAELVRLTTGMEGAYGRGTYCRrgalgqPAATtgdSTCYQIN------------------ 178  Gemm...
ASGPB:GKIL_2224        108 RKFKLLKLNLIapPPSDSkEQQELTRLTVGMESEYGKGTYCR-------SPVdgkQECLQLN------------------ 162  Gloe...
WP_012048875           118 RKLDILKQSIVlpAPATPgAAKELNDLATRLQSAYGKGKGTL------RGEE------INGS------------------ 167  Sphi...
BAK67040               108 RKLDIMRSGIVlpAPTKPgAAAELNEIATRLQSTYGKGRGTL------DGKE------LTGS------------------ 157  Sphi...
WP_015456931           106 RKLDILRQGIVlpAPATEgAATELNALSTRMSSTYGKGRGTL------AGKE------INGS------------------ 155  Sphi...
Q8EE93                 118 RKLNILRSALVlpAPLDPaKNAELAQISSELNGLYGKGKYCF---------Ad--GKCMTQP------------------ 168  Shew...
WP_013051597           111 RKLNILRSSLVlpAPLDPeKNAELAGISAQLNGLYGKGKYCF---------Dd--GRCLTQP------------------ 161  Shew...
5AMB_A                     --------------------------------------------------------------------------------      human
13_pfamImport          153 mtmlrderlyvycmqavmkarkvdqgslylyvminylkegsddkigddhnamdfdrtswsrtmvnltkwkvamkrndegg 232 
PDM63802                   --------------------------------------------------------------------------------      Pris...
PRJNA194094:J421_0092      --------------------------------------------------------------------------------      Gemm...
ASGPB:GKIL_2224            --------------------------------------------------------------------------------      Gloe...
WP_012048875               --------------------------------------------------------------------------------      Sphi...
BAK67040                   --------------------------------------------------------------------------------      Sphi...
WP_015456931               --------------------------------------------------------------------------------      Sphi...
Q8EE93                     --------------------------------------------------------------------------------      Shew...
WP_013051597               --------------------------------------------------------------------------------      Shew...
5AMB_A                 142 ----DLTNILAS-SRSYAMLLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAYWRSWYN--------SPTFE 208  human
13_pfamImport          233 ctyeDLKRVMGE-SRDDDELLWAWQGWRNETGAPNRDDFQRFVELSNTVAQQSGFDDHGDYQRRQYD--------TPHLE 303 
PDM63802               435 ----DLESIART-DKDANRLGHLYTTFNQNVAA-LKGNYQKIIELTNKGAKMNGFGSGSSMWLSSFDlstkdtppQFDVM 508  Pris...
PRJNA194094:J421_0092  179 ----DLSRALAE-SHDPAVLLDAWRGWHA-IGAPLRPKYERFVALSNEGARELGFADLGAMWRANYDm------pADQFP 246  Gemm...
ASGPB:GKIL_2224        163 ----DLERILRT-SRDPKELLDVWQGWHQ-IARPLRPRYERFVQLSNKGARELGFADTGAMWRSNYDm------sPAQFS 230  Gloe...
WP_012048875           168 ----DIEAAMGT-NRNPAELKEMWVSWHDNVGRPMRGDYAKLVEIANKGAVDLGYKDLGAMWRAGYDm------pADDFA 236  Sphi...
BAK67040               158 ----DIEAEMANlSHTPAQFSEMWTSWHDRVGAPMKADYVRLVDIANEGAKELGFADAGAMWRSGYDm------pPDEFA 227  Sphi...
WP_015456931           156 ----DIEEKMGT-VRNPDQLKEMWASWHDNVGKPMKADYARMVEIANQGAKELGYKDLGAMWRSNYDm------sPDEFA 224  Sphi...
Q8EE93                 169 ----ELSSLMAE-SRDPAKLLEAWKGWRE-IAKPMRPLFQREVELANEGAKDLGYANLSELWRSQYDm------kPDEFS 236  Shew...
WP_013051597           162 ----ELSAIMAE-SSDPKLLLEVWQGWRE-IAKPMRPLFQREVELANEGAKDLGYADLSVLWRSQYDm------kPDEFS 229  Shew...
5AMB_A                 209 DDLEHLYQQLEPLYLNLHAFVRRALHRRYG-DRYINLRGPIPAHLLGDMWAQSWENIYDMVVPFPD-KP--NLDVTSTML 284  human
13_pfamImport          304 QTMSDLLTNLQPLYDNLHAFIRRRLYDIHG-PEVIDLNGPIPSHLLGGMWSHSWSNLFDVAKPYETdDD----DPTEFLQ 378 
PDM63802               509 KKLNEVFKQVSPFYKQLHAYMRRQIAGLYKnPEGLTKDLAIPAHLFGTLEGGDWSAHYLDTRPYDD-EDsvPEEILAAFH 587  Pris...
PRJNA194094:J421_0092  247 REVERLWKQVEPLYVALHAYVRTRLNQQYG-DAVVAKDGMIPAHLLGNMWAQEWGNVYPIVAPPNA-SP--TYDLTALLK 322  Gemm...
ASGPB:GKIL_2224        231 AEVERLWQQVRPLYLSLHAYVRTKLGEQYG-TQLVPADGPIPAHLLGNMWAQEWGNIYPLAAPAND-QR--GYDLTQLLT 306  Gloe...
WP_012048875           237 KMMDRLWTQVKPLYDALHCYTRTKLNEKYG-DAVQAKTGPIRADLLGNMWAQEWGNIYDIVAPKGAgDL--GFDIGDLLV 313  Sphi...
BAK67040               228 ALTEALWQEVKPLYDALHCYTRTKLNEKYG-DAVQSPTGPIRADLLGNMWAQEWGNIYPIVAPAGTgDL--GYDIGDLLR 304  Sphi...
WP_015456931           225 RLTDKLWLQVKPLYDQLHCYTRTKLNEKYG-DGVQPRTGPIRADLLGNMWAQEWGNIYDVVAPAGAgDL--GYDTTDLLK 301  Sphi...
Q8EE93                 237 QELDRLWSQVKPLYESLHCYVRGELNKEYG-DAIAPKTGPIPAHLLGNMWAQQWGNVYDLVAPENA-DP--GYDVTELLA 312  Shew...
WP_013051597           230 NELDRLWGQVKPLYDSLHCYVRGELNEEYG-DEVVPANGPIPAHLLGNMWAQSWGNVYDKVSPQDA-DP--GYDLTQLLA 305  Shew...
5AMB_A                 285 QQ---------------------GWQATHMFRVAEEFFTSLELSPMPPEFWEGSMLEKPADgREVVCHA-SAWDFYNRKD 342  human
13_pfamImport          379 EQ---------------------NYDIRRLYETAEEFYTSMGYEELPESFWENSVFGQLQDgRNVSCEP-TSWDFHNQTD 436 
PDM63802               588 GQ---------------------NITQKEMFVKAYRYFKAVGFPKLPKSFWTNSVFARVWS-KDMICNPpAAIDMRDGEE 645  Pris...
PRJNA194094:J421_0092  323 AK---------------------NVDAKGMAKYAEGFFTSMGFAPLPATFWERSMLVKPRD-REVVCHA-SAWTIDNKND 379  Gemm...
ASGPB:GKIL_2224        307 AK---------------------KVDEREMFRYGERFFTSLGFAPLPKTFWERSMLTKPRD-RDVVCHA-SAWDIDNLDD 363  Gloe...
WP_012048875           314 AK---------------------QYDPVKMVKAGEGFYTSLGFDKLPDSFWTRSQITKPRD-REVVCHA-SAWDIDNVDD 370  Sphi...
BAK67040               305 AKgfvqttpqtidtpdtpetqrrGYWEKQMFRIGEGFYSSLGFDPLPETFWQRTQFIAPRD-REVVCHA-SAWDVDNRND 382  Sphi...
WP_015456931           302 AK---------------------GYDALKMVKGGENFFSSLGFAPLPDSFWQHSQFTKPAD-REVICHA-SAWDVDNKDD 358  Sphi...
Q8EE93                 313 QK---------------------GYDEHRMVKQAESFFTSLGFAPLPDSFWSRSLFLQPKD-RDVVCHA-SAWDLDNLDD 369  Shew...
WP_013051597           306 EH---------------------DYDEVKMVKQAESFFSSLGFDELPDSFWERSLFVQPKD-RDVVCHA-SAWDLDNLDD 362  Shew...
5AMB_A                 343 FRIKQC-TRVTMDQLSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAIGDVLALSVSTPEHLHKIGLL--DRVTNDTE 419  human
13_pfamImport          437 FRITTCsSEVTIDELSKAHNILGHTQYQNSYSHQPTAFREPASPALYEAIADLTSSEVFSPSYLRQLGLSl-DERNDD-K 514 
PDM63802               646 FRVKMC-AQLGDTDFKQAHSLLAQTFYQFLYRKQPFSFREAANPSFNEAIANVFSILSSNTDYLFSQSLIapDSLVPKES 724  Pris...
PRJNA194094:J421_0092  380 VRIKAC-LEPTADDFVTIHHEEGHNFYQRAYSSQPYLFQNGANDGFHEAIGDAIALSI-TPGYLQQAGLL---ATPPSAA 454  Gemm...
ASGPB:GKIL_2224        364 VRIKMC-AEVTDSDFVTIHHELGHNFYQRAYKTQPPLFQNSANDGFHEAVGDTIALSV-TPDYLVKVGLL---GKAPGPE 438  Gloe...
WP_012048875           371 LRIKMC-TKVNSDDFVTIHHELGHNFYQRAYNKQPYLYLNGANDGFHEAIGDFIALSV-TPDYLVRIGLLd-PAKVPSAD 447  Sphi...
BAK67040               383 IRVKMC-TKVNSDDFVTIHHELGHNYYQRAYQKHGYLYLNGANDGFHEAIGDFIALSI-TPQYLVQIGLLd-PAKVPSAD 459  Sphi...
WP_015456931           359 LRIKMC-IKVNGDDFTTIHHELGHNYYQRAYNKQPYLYLNGANDGFHEAIGDAIALSI-TPDYLVRIGLLd-PAKVPPAD 435  Sphi...
Q8EE93                 370 IRIKMC-IQKTAEDFTVIHHELGHNFYQRAYKQQPFLFKNSANDGFHEAIGDTIALSI-TPSYLKQIGLL---EEVPDAS 444  Shew...
WP_013051597           363 IRIKMC-IQKTAEDFTVIHHELGHNYYQRAYKNQPFIFKNSANDGFHEAIGDTIALSI-TPSYLKQIGLL---DEVPDAS 437  Shew...
5AMB_A                 420 SDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNFDWWYLRTKYQGICPPVT-RNETHFDAGAKFHVPN-VTP 497  human
13_pfamImport          515 IQLNGLMRTALDSLALLPYANAVDQWRWGVFNGSIQPDRYNSEWWDLRSEYEGIEPGVE-RTDADFDPGAEFNIVS-DSS 592 
PDM63802               725 QVINRLYKEALTHFVKLPFDLAADEWRIEYFNGKTVPSKLNERWWQLRERYEGVRHVSPtVNASTLDALINTAIVQeHSP 804  Pris...
PRJNA194094:J421_0092  455 ADTALLLRQALDKVAFLPFGLMIDQWRWGVFSGAIKPSEYNKAWWDLRARYQGVVPPVA-RSEADFDPGAKYHVPA-NTP 532  Gemm...
ASGPB:GKIL_2224        439 SDTGFLLKQALDKVAFLPFGLLIDQWRWKVFSGETQPKDYNKSWWELRERYQGIAPPLA-RSEADFDPAAKYHVAA-NTP 516  Gloe...
WP_012048875           448 KDIGLLLRQAMDKVAFLPFGLLMDKWRWGVFSGQISPASYNKAWTDLRLQYQGIVPPEA-RDEGDFDPGAKYHIPG-NTP 525  Sphi...
BAK67040               460 KDIGLLLRQAMDKVAFLPFGLLIDRWRWGVFDGSIRPADYNKAWTDMRLRYQGIVPPTD-RPADSFDPGAKFHVPG-NTP 537  Sphi...
WP_015456931           436 KDIGLLLRQAMDKVAFLPFGLLVDKWRWGVFDGSIAPQDYNKAWTALRLQYQGITPPVE-RGADAFDPGAKYHVPA-STP 513  Sphi...
Q8EE93                 445 KDIGLLLKQALDKIAFLPFGLMIDQWRWKVFSGEITPAQYNQAWWELREKYQGVKAPTP-RSETDFDPGAKYHVPG-NVP 522  Shew...
WP_013051597           438 KDIGLLLKQALDKVAFMPFGLMIDQWRWKVFSGEITPDQYNQAWWDLREKYQGVKAPIE-RSEADFDPGAKYHVPG-NVP 515  Shew...
5AMB_A                 498 YIRYFVSFVLQFQFHEALCKEAGYEGPLHQCDIYRSTKAGAKLRKVLRAGSSRPWQE----------------------- 554  human
13_pfamImport          593 YAKHFLGQIMKFQFLKSLCEAAGHTGPIQDCNLYGNRVAGQLITDAFRGAGDFVSGAyhgagdmwrsysdmreantigad 672 
PDM63802               805 ATRQMITYVMQFQILKALCPEGSI---LSEGCIL-SEDTTGKLREAMEKGSSINWLE----------------------- 857  Pris...
PRJNA194094:J421_0092  533 YMRYFLARVLQFQFYRAMCRAAGHTGPLYRCSFYGSKEAGAKLARMLEAGQSKPWQE----------------------- 589  Gemm...
ASGPB:GKIL_2224        517 YIRYFLARILQFQFHRALCREAGYTGPLHRCSIYANRAAGTKLAAMLAAGQSQPWPD----------------------- 573  Gloe...
WP_012048875           526 YARYFLARILQFQFYKAACEQAGWKGPLHRCSFYGNKEVGAKLDAMLKMGASKPWPD----------------------- 582  Sphi...
BAK67040               538 YTRYFLARILQFQFYEAACRQAGWKGPLHRCSFYGNKEVGKRLNAMLEMGASKPWPD----------------------- 594  Sphi...
WP_015456931           514 YTRYFLARILQFQFYKAACDQAGWKGPLHRCSFYGNKEVGANLNKMLEMGMSKPWPD----------------------- 570  Sphi...
Q8EE93                 523 YTRYFLAHILQFQFHKALCETAGDKGPVHRCSIYGNQAAGEKLNRMLELGSSQPWPM----------------------- 579  Shew...
WP_013051597           516 YTRYFLAHILQFQFHKSLCETAGDTGPVHRCSIYGNKAAGSKLNTMLEMGLSRPWPD----------------------- 572  Shew...
5AMB_A                 555 ---------------------------------------VLKDMVGLDALDAQPLLKYFQLVTQWLQEQNqqNGEVLGW 594  human
13_pfamImport          673 kyfhargnfdaaqrgsggrfaaevistamqlgktrswteIFYILTQQYNLDTSPLLEYFQPLNEFLERENrrNGDSTG- 750 
PDM63802               858 ---------------------------------------ALKIVTGKGELDVAPLLEYYEPLINWLQNTNevDQVIVGW 897  Prist...
PRJNA194094:J421_0092  590 ---------------------------------------TLYEMTGERDMDAGAMLEYFAPLKAWLDRQN--AGHPVGW 627  Gemma...
ASGPB:GKIL_2224        574 ---------------------------------------TLYAMTGERQMDASAMLDYFAPLKSWLDAQN--QGKKVGW 611  Gloeo...
WP_012048875           583 ---------------------------------------ALQAFTGSREIDGSAMIAYFKPLMTWLEKQN--KGQRCGW 620  Sphin...
BAK67040               595 ---------------------------------------ALEAFTGSRKMSGKAMLAYFAPLGKWLDQQN--KGKQCGW 632  Sphin...
WP_015456931           571 ---------------------------------------ALQAFTGSREMDGTAMIAYFKPLMTWLEQQN--KGKTCGW 608  Sphin...
Q8EE93                 580 ---------------------------------------ALKEVTGTETMDANAVLDYFAPLKTWLDEQNkaANRQCGW 619  Shewa...
WP_013051597           573 ---------------------------------------ALKVVTGSPEMDASAVLDYFAPLQVWLNEQNtqAKRQCGW 612  Shewa...
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