1XQ8


Conserved Protein Domain Family
Synuclein
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pfam01387: Synuclein 
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Synuclein
There are three types of synucleins in humans, these are called alpha, beta and gamma. Alpha synuclein has been found mutated in families with autosomal dominant Parkinson's disease. A peptide of alpha synuclein has also been found in amyloid plaques in Alzheimer's patients.
Links
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Statistics
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PSSM-Id: 426235
Aligned: 13 rows
Threshold Bit Score: 132.725
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1XQ8_A         1 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGvvhgVATVAEKTKEQVTNVGGAVVTGVTAVAQK 80  human
XP_011602812   1 MDAFMKGFSKAKDGVVAAAEKTKQGVTGAAEMTKDGVMFVGTKTKDG----VTVVAGKTVSGVSQVGGAMVTGVTAVAQK 76  torafugu
2_pfamImport   1 MDAFKKGFSKARDGVAAVAEKTKQGVTGAAEMTKDGVMFVGNKTKDG----VTTDFPTAVSGVSQVGGAMVTGVTAVAHK 76 
XP_003455005   1 MDALMKGFSKAKDGVVAAAEKTKQGVTGAAEMTKDGVMYVGTKTKDG----VTTVAGKTVSGVSQVGEAVVTGVTAVAQK 76  Nile tilapia
XP_005812724   1 MDALMKGFSKAKDGVVAAAEKTKQGVTGAAEMTKDGVMYVGTKTKDG----VSTVAEKTVSGVSHVGGAVVTGVTAVAQK 76  southern platyfish
XP_007478272   1 MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGTKTKEGvvqsVTSVAEKTKEQANLVSDVMVASVNTVANK 80  gray short-tail...
XP_003994186   1 MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKENvvqsVTSVAEKTKEQANAVSEAVVTSVNTVAIK 80  domestic cat
O76070         1 MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKENvvqsVTSVAEKTKEQANAVSEAVVSSVNTVATK 80  human
XP_008112683   1 MDVFKKGFSIAKEGVVAAAEKTKQGVTEAAEKTKEGVMYVGAKTKEGvvqsVTSVAEKTKEQANLVGESVVASVNTVAKQ 80  green anole
XP_015203361   1 MDVLKKGFSIAKEGVVAAAEKTKQGVEEAAAKTKEGVMYVGTKTKEGvvhsVNTVAQKTTEQANIVGETVVGSANQVSAK 80  spotted gar
XP_012321796   1 MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGvvqgVASVAEKTKEQASHLGGAVFS-------- 72  Ma's night monkey
1_pfamImport   1 MDMFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSEIRSK---------DRARGSGSVVRDQSNESTEGITMG 71 
XP_008991227   1 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGvvhgVTTVAEKTKEQVTNVGGAVVTGVTAVAQK 80  white-tufted-ea...

1XQ8_A        81 TVEGAGSIAAATG--FVKKDql----gKNEEGAPQEG-ILEDMPvDPDNEAYEMPSEE 131 human
XP_011602812  77 TVESAGSIAAATG--LVKKE-------PGKQGDDAAT-AENMAEsPDVTDPAEATEED 124 torafugu
2_pfamImport  77 TVEGAGNMVVATG--LVKKD-------PAKQSDEASA-VQDMAEsPVDTDPADAME-- 122
XP_003455005  77 TVEGAGTIAAATG--LVKKD-------PAKQSDDASA-VQDVAEsPVDTDPADVTEED 124 Nile tilapia
XP_005812724  77 TVEGAGNIAAATG--LVKKD-------PAKQGEDVSA-VPDAVEsPIDTDSTEPTEED 124 southern platyfish
XP_007478272  81 TVEEAENIVVTSG--IVRKEdlv-npaQPEHGAP-------------EEQPAEAAEVT 122 gray short-tailed opossum
XP_003994186  81 TVEEAENIAITSG--VIRKEdle-qpaPSQEDKAa----------KAEEEVAEEAKSG 125 domestic cat
O76070        81 TVEEAENIAVTSG--VVRKEdlr-psaPQQEGEAs----------KEKEEVAEEAQSg 125 human
XP_008112683  81 TVEGAETVVSSTG--VVKMEdlh-peqPEEPLAD-----------AEEDAPVEATETS 124 green anole
XP_015203361  81 TVEGVENVVASTG--VVNPDda----vNQEDFSR-----------PPEGTVEQATDAV 121 spotted gar
XP_012321796  73 ---GAGNIAAATG--LVKREefptdlkPEEVAQEAAEePLIEPLmEPEGESYEDPPQV 125 Ma's night monkey
1_pfamImport  72 GIRGDDGSSVGVGrvLVKSSqww-hgiPEEVGQEVGEePMAEPLlDTEGESYEEPPQE 128
XP_008991227  81 TVEGAGNIAAATG--FVKKDhl----gKSEEGAPQEGiLEDMPV-DPDNEAYEMPSEE 131 white-tufted-ear marmoset
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