1AOR


Conserved Protein Domain Family
AFOR_C

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pfam01314: AFOR_C 
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Aldehyde ferredoxin oxidoreductase, domains 2 & 3
Aldehyde ferredoxin oxidoreductase (AOR) catalyzes the reversible oxidation of aldehydes to their corresponding carboxylic acids with their accompanying reduction of the redox protein ferredoxin. This family is composed of two structural domains that bind the tungsten cofactor via DXXGL(C/D) motifs. In addition to maintaining specific binding interactions with the cofactor, another role for domains 2 and 3 may be to regulate substrate access to AOR.
Statistics
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PSSM-Id: 426196
Aligned: 232 rows
Threshold Bit Score: 180.882
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1AOR_A         220 VVREKV-NKLRNDP-VAGgGLPKYGT------------AVLVniiNENGLYPVKNFQT-GVypy-----ayeQSG---EA 276 Pyrococcus fu...
WP_014809790   231 LGANNQ-HVVPNSPqPWS-EHYNPGSrwvasagrrwgaAYPG---IETGPCEPHNLNRiAYrt-------nnAAFflgEK 298 Desulfomonile...
P76192         228 IGANNN-HVVPSTPqSWA-EYSDPKSrwtarkglfwgaAEGGp--IETGEIPPGNQNTvGFrt-------ykSVFdlgPA 296 Escherichia c...
jgi:Nther_2279 229 IGSNNQ-HVVPNSPlPWA-EHYDPGSrwtgkpglywgaADPP---VETGECHPDDVNSlGYrc-------qkAVFdagDI 296
jgi:Spirs_1144 229 IGANNQ-HVVPKFPqPWA-EFNNPATrwtsaedkywgaAEPP---VKTGTNPPQDINRiGFrt-------lkSILdltDV 296
WP_012159985   231 IGSNNQ-HVVPSTPqPWA-EYHWTGSrwtgqpglfwgaAEPP---VETGECPVGDPNRvGLrt-------qkAIFdlgAV 298 Alkaliphilus ...
jgi:Geob_0212  224 VLDYIKhREENPIPdVMP-ILAGLGS------------PQEMk--VHDEKWHTENFNWgNArtrrkdfwteeVDHawaET 288
WP_014809765   224 VLNYIKfRNDNPIPgVMP-ILAGLGS------------PQEMk--VHDEKWHTENFMWgNSrvrrkdfwndeIAKqwaET 288 Desulfomonile...
WP_014959687   224 VREYIDfRNENPIPeVMP-ILSGIGS------------PQMMk--HVDEKWHTESFAWgNArtrrkdfwtkeIEEsweKS 288 Desulfobacula...
jgi:Clos_2143  231 IGANNQ-HVVPNSPqQWA-EYHSAGSrwtaqtalfwgaAVPP---VETGECPPGNPNKvGLrt-------qkAVFdlgAV 298
1AOR_A         277 MAAkyLVRN-KpCYACPIGCGRVNRlptvgetegpEYE----SVWALGANL--------------------GINDLASII 331 Pyrococcus fu...
WP_014809790   299 AWKy-TIRGnG-CTACPIRCHTMLKvpg----vstKYG----ILETGQNTCvgllfgkaf--fknfpdgpkGETAIEACM 366 Desulfomonile...
P76192         297 AEKy-TVKMsG-CHSCPIRCMTQMNipr-----vkEFG----VPSTGGNTCvanfvhttifpngpkdfedkDDGRVIGNL 365 Escherichia c...
jgi:Nther_2279 297 AEKy-TVRMgG-CHACPVRCHARVEfpq-----leEHG----YSRYSGNTCvgwatpar-----mmikgtsDEGDFMART 360
jgi:Spirs_1144 297 AEKy-TVRMgG-CASCPIRCHSQMKipq-----leQYG----YPPYVSSTCvgffspgav--mikgvqdmnGEGLMIARA 363
WP_012159985   299 AEEr-TIKMgG-CHSCPIRCQSNLKvpe-----leKYG----LTPYATSTCigfinpgt----vmnvnwqgTEQELIIKS 363 Alkaliphilus ...
jgi:Geob_0212  289 MEKa-RTRLiS-CYNCPMKCGATISmeg-----lpTYMmkcfTKLTYTMAA---------------------YSDLDFGL 340
WP_014809765   289 LDSm-RTRLiS-CYNCPMTCGATISppg-----lpTYMmkcfSKLTYTMAA---------------------FSDLEFGL 340 Desulfomonile...
WP_014959687   289 QRGa-IQRFiS-CFNCPQQCGALIshd-----dvpKYMikcfSKLTYAMAA--------------------HVDDLDFSW 341 Desulfobacula...
jgi:Clos_2143  299 AEEr-TIKMgG-CHSCPIRCQSNLKvpe-----leKYG----LTPYAASTCinfstpgsvmhkgysdgdpkGEVALITKS 367
1AOR_A         332 EANHMCDELGLdTISTGGTLATAMELYEKGHIKDEELg--------DAPpfRWGNTEVLHYYIEKIAKREG-FGDkLAEG 402 Pyrococcus fu...
WP_014809790   367 VGMHLADDLGL-WENYGQLQRDFQMLYYNGTMSRKVPekefkgyswDKY--EQGDPTFLFELLPRIARKEGeLATaLGLG 443 Desulfomonile...
P76192         366 VGLNLFDDYGL-WCNYGQLHRDFTYCYSKGVFKRVLPaeeyaeirwDQL--EAGDVNFIKDFYYRLAHRVGeLSH-LADG 441 Escherichia c...
jgi:Nther_2279 361 LGKHLVDDYGI-WDNYCLIVADFEYAYENGILEEVLPeeeyeeipwDLL--EDGDPAFLKDFYRRIAFKEGkFGEtMGKG 437
jgi:Spirs_1144 364 LGAQITNDYGI-WCNYLQIGRDFNYAYNKGILKKVLPkaeydsirfDLL--EAGDPAFLLDFYQRIAMKEGeFSH-MADG 439
WP_012159985   364 LGSRLADDYGI-WSNYGQLGRDFRYMLTTGKFKEVLPkeeydsirwDLA--ESGDPEFLLEFYRRIALKEGeFWK-VAQG 439 Alkaliphilus ...
jgi:Geob_0212  341 RIAQKATEYGLdGFSAPQVMAFAFELLEKGILTEKDF---------PGLp--eDNEEKFFYLLDKIVRRDG-IGDvLANG 408
WP_014809765   341 GIAQSATEYGVdGFSTPQVMAFALELYENGILTDDDF---------PGMp--aDNEGRFYWLLDRIVRREG-IGDiLANG 408 Desulfomonile...
WP_014959687   342 KICQRAFQYGLdSFSTPQILAFGVELYEAGIFTDDDF---------EGCp--sDNEGRFFWLLDKVARREG-IGDyLADG 409 Desulfobacula...
jgi:Clos_2143  368 LGSRLADDYGI-WSNYGQLPRDFKYAYNSGKLKEVLPaeeynsipwNLL--EAGDPAFLLEFYRRIAFKEGeFSK-LGLG 443
1AOR_A         403 SYRLAESYG-----H-----------------------------------------------------------PEL-SM 417 Pyrococcus fu...
WP_014809790   444 TGYLLERWGipeqeWlenrdllywklghpkhhsnedagqcgvi----intqynrdaqchshsnftrnglpievqKRL-AA 518 Desulfomonile...
P76192         442 SYAIAERWNlgeeyWgyaknklwspfgypvhhaneasaqvgsi----vncmfnrdcmththinfigsglplklqREV-AK 516 Escherichia c...
jgi:Nther_2279 438 SYWVATEWEfgddyWhgddyglfsvwnykfgypqhhsnetygqvgalincmfnrdaqlhthvnlqgsglpheiqEEI-VE 516
jgi:Spirs_1144 440 AYLLAKRWGfgddyWdeeayglwnkdfgyphhhsneadaqvgt---lvnliknrdaqnhshnnflgsglpleiqKEI-AA 515
WP_012159985   440 PYWMAKEWKlgndyWdnygnnvwskmafpkhhsneagaqvgvl----vnimfnrdanshthmnlldnglpieilKDI-LA 514 Alkaliphilus ...
jgi:Geob_0212  409 TYWAAQEIGk---gA-----------------------------------------------------------EEYaHN 426
WP_014809765   409 TYWAAKQIGk---gA-----------------------------------------------------------EAYaHN 426 Desulfomonile...
WP_014959687   410 TYWAAKRIGk---gA-----------------------------------------------------------EKYdHN 427 Desulfobacula...
jgi:Clos_2143  444 PHYLDKEWNlgadyWnsygnniwskmaypkhhsneagaqvgvl----vnvmfnrdanshthmnmigaglpitllKEI-AG 518
1AOR_A         418 TVKKl-----ELPAYDPRGaeghglGYATNNRggchiknymispei------------------------------lgyp 462 Pyrococcus fu...
WP_014809790   519 EIWG------SPDAVDSVA------AFAPMNK------------------------------------------------ 538 Desulfomonile...
P76192         517 ELFG------SEDAYDETK------NYTPIND------------------------------------------------ 536 Escherichia c...
jgi:Nther_2279 517 EIVG------SKDAIDPPA------DYTPVNE------------------------------------------------ 536
jgi:Spirs_1144 516 EVWG------GGEAIDEPG------HYTPMNK------------------------------------------------ 535
WP_012159985   515 EKFG------SGDALDPKA------NYTPMNE------------------------------------------------ 534 Alkaliphilus ...
jgi:Geob_0212  427 NIKKheqlplKLSMLNPIyy----lMYCTGEKinitqiegqfpqapypkreqreefvkdwfqvpddkfkqifldweprge 502
WP_014809765   427 NIKKheqlplKLSMLNPIyf----lMYCTGEKinitqiegqfpqapfltmeereafvkdwfqvpdekfkqyfldweprge 502 Desulfomonile...
WP_014959687   428 TTKKheqmniKLGMLDPLyy----lMYATNEKisitqmegnwpqapfpskenresfvkdwpqlpdekfktyfteweprgd 503 Desulfobacula...
jgi:Clos_2143  519 EVWG------SPDALDAPQ------DYTPMNE------------------------------------------------ 538
1AOR_A         463 ykmdphdvsdDKIKMLILFQDLTALIDSAGLCLFTTfgl-----gaDD------YRDLLNAALGWDFTTEDYLKIGERIW 531 Pyrococcus fu...
WP_014809790   539 ----------YKAKMAKWSLLRKELHDSLSLCNWMGpwvasplrerDYrgddsiESLLYSLATGDKKTSQELDRVAERIF 608 Desulfomonile...
P76192         537 ----------AKIKYAKWSLLRVCLHNAVTLCNWVWpmtvsplksrNYrgdlalEAKFFKAITGEEMTQEKLDLAAERIF 606 Escherichia c...
jgi:Nther_2279 537 ----------YKAKYAKWSIIRNLLHDSLTLCNWMWpmhasprkewDYrgdtalEAKFLSVATGEEYTEEELDRLGERMF 606
jgi:Spirs_1144 536 ----------PKAVFAAWSLKRNFLHDSLTLCNWMWpmtvsplkekGYrgdtamESKYYTLATGKEISEAELDKEALKLI 605
WP_012159985   535 ----------YKAKFAKWSVDRNFLHDSITLCNWVWpmtaspskerNYrgdtalEAKFFSLATGIETTEDELDFAAERIS 604 Alkaliphilus ...
jgi:Geob_0212  503 ksmphyptvdMCCDIVDWQERMHYIDDALGQCAGLSsf------plKPpyhihnYPKFIEAGAGIEMDEEKLTLAAKRYR 576
WP_014809765   503 ksmpfyptveMCCDIVDWQERMHYIDDALGMCAGLSsf------plKPpyhihnYPKFISAGAGIDMDEEKLTQATKRYR 576 Desulfomonile...
WP_014959687   504 kanpaypdpqTASEIVDWMEMLHNIDDALGICCGMGsf------clKPpyhvhnYPKLISAATGMDVDRYDLKKIVNRSR 577 Desulfobacula...
jgi:Clos_2143  539 ----------YKARFAKWSLDRNFLHDSITLCNWVWpmtvspskerNYrgdtalEAKFFSLATGIETTEAQLDFAAERIA 608
1AOR_A         532 NAERLFNLKAgLD----PaRD----DTLPKRFL-----EEPM--PEGPNKghtvrLKEMLPRYYKLRGWTE-DGKIPKEK 595 Pyrococcus fu...
WP_014809790   609 LLHRALTIRD-MGtkdmRtKH----DTIPHWVFtd--pkDKAafSKGTIRmdeedIKLAMDMYYEEMGWDKqTGSPTGDT 681 Desulfomonile...
P76192         607 TLHRAYTVKL-MQtkdmRnEH----DLICSWVFdk--dPQIPvfTEGTDKmdrddMHASLTMFYKEMGWDPqLGCPTRET 679 Escherichia c...
jgi:Nther_2279 607 TLHRALTVKQ-MDtadmRnEH----DVISDWVFdm--dPDMEpfEEGTIKmdrddMQKALTLFYKEMGWDEeTGAPTREC 679
jgi:Spirs_1144 606 TLHRAITMRQ-MNtmnmRnEH----DLIPKWVFda--dKDKKpyDKGTNKldredMELAKDMLYEEFGWDKkTGAPTRAT 678
WP_012159985   605 TLHRALTVKN-MNtvdmRnEH----DTIPEWAFvdlknPDAKpfTEGTVImdrddMQLALTMLYKEYGWDEkTGAPTRAC 679 Alkaliphilus ...
jgi:Geob_0212  577 TLVRAINIRRgMR----RiDEtppaNHWKNRFP------ELE--------------KELLDSYYKLKGWND-DGIPTKET 631
WP_014809765   577 TLIRAYNVRRgMR----RkDDkppeNHWKKRFP------ELE--------------KQLLDTYYQFKGWNR-QGIPTKES 631 Desulfomonile...
WP_014959687   578 NLHRAVNLIRgMV----RaDEkppeDHWKHRFP------ELE--------------EDLLTKYYTFKGWNY-DGVPTRER 632 Desulfobacula...
jgi:Clos_2143  609 TLHRALTIKN-MNtvdmRnQH----DTIPEWAFidaknPDAKpfTKGTVMmdredMQLGLTMLYKQYQWDEkTGAPTRAA 683
1AOR_A         596 LEELGI 601 Pyrococcus furiosus
WP_014809790   682 YQRLGL 687 Desulfomonile tiedjei
P76192         680 LQRLGL 685 Escherichia coli K-12
jgi:Nther_2279 680 LEELDL 685
jgi:Spirs_1144 679 LEDLGL 684
WP_012159985   680 LERLNL 685 Alkaliphilus oremlandii
jgi:Geob_0212  632 LDELGL 637
WP_014809765   632 LHELDL 637 Desulfomonile tiedjei
WP_014959687   633 LEELDL 638 Desulfobacula toluolica
jgi:Clos_2143  684 LERLNL 689
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