2VOE,1X15,1L7E,2EEZ


Conserved Protein Domain Family
AlaDh_PNT_C

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pfam01262: AlaDh_PNT_C 
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Alanine dehydrogenase/PNT, C-terminal domain
This family now also contains the lysine 2-oxoglutarate reductases.
Statistics
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PSSM-Id: 426165
Aligned: 68 rows
Threshold Bit Score: 178.458
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2VOE_F        141 AAQVGAYHLMRTQGGRGVLMGGVPgvePADVVVIGAGTAGYNAARIANGMGATVTVLDINIDKLRQLDAeFCGR-IHT-- 217  Mycobacterium...
Q8IKU3        785 AVLEAFFILPRFSKSSITAAGKIN---PAKVFVIGAGVAGLQAIITAKSLGAIVYSHDSRLATEEEVKS-CGGIfIRIpt 860  Plasmodium fa...
Q24858        706 CVIEASNKFGRLLMGQVTAAGKSQ---PANVLVIGVGVAGLAAISTAKALGAQVKAFDTRKAAKEQAES-VGAEfCTVsv 781  Entamoeba his...
P73496        162 AIIEAANRFGRFFTGQITAAGKVP---PAKVLVIGAGVAGLAAIGAAKSLGAIVRAFDTRPVVKEQVES-LGGEfLLLdf 237  Synechocystis...
WP_010972360  143 AVIEAGNNFGRFFTGQVTAAGKVP---PAKVLVIGAGVAGLAAIGTATSLGAITYAFDVRPEVAEQIES-MGAEfVYLdf 218  Agrobacterium...
1X15_A        148 AIVEAAHEFGRFFTGQITAAGKVP---PAKVMVIGAGVAGLAAIGAANSLGAIVRAFDTRPEVKEQVQS-MGAEfLELdf 223  Escherichia coli
Q7VL24        141 AVIEAANVFGSFFTGQITAAGKVP---PAKVLVIGAGVAGLAAIGAANSLGAIVRAFDSRPEVKEQVKS-MGAEfLAIdf 216  [Haemophilus]...
Q9F3D4        149 AVIEAAHVFGRFFTGQVTAAGKVP---PAKVLVAGAGVAGLAAVGAASSLGAIVRATDPRPEVADQVRS-LGGEyLAVdv 224  Streptomyces ...
Q18031        169 AVIEAANHFGRFFTGQITAAGKVP---PAKVLVIGGGVAGLSAIGTSRGMGAVVRGFDTRAAVKEHVES-LGAQfLTVnv 244  Caenorhabditi...
Q6NYQ7        199 AVVLAANNFGRFFTGQITAAGKVP---PAKVLIIGGGVAGLAAAGSARAMGAIVRGFDTRAAALEQFKS-LGAEpLEVdi 274  zebrafish
2VOE_F        218 ---------------------RYSSAYELEGAVKRADLVIGAVLVPGAKAPKLVSNSLVAHMKPGAVLVDIAID------ 270  Mycobacterium...
Q8IKU3        861 sergdiln---mstdmnneeyIKVQSNLFKKIIKKCDILICSASIPGKTSPKLVTTEMIKLMKPGSVAVDLSTEfgdkkn 937  Plasmodium fa...
Q24858        782 dedaenkf---gyanaasqrlIDAEYALFRQLLPETDIVITTANVPGKKSPILITQDMVDSMKIGSVIVDLAAA------ 852  Entamoeba his...
P73496        238 kedgtgqg---gyakvmseefIAAEMALFAAQAKEVDIIITTALIPGRPAPKLITEPMVKSMRAGSVVVDLAAE------ 308  Synechocystis...
WP_010972360  219 adqqqdgaatggyaapsspefREKQLEKFRELAPQIDIVITTALIPGRDAPKLWLADMVAAMKPGSVIIDLAAE------ 292  Agrobacterium...
1X15_A        224 keeagsgd---gyakvmsdafIKAEMELFAAQAKEVDIIVTTALIPGKPAPKLITREMVDSMKAGSVIVDLAAQ------ 294  Escherichia coli
Q7VL24        217 eedagsgd---gyakvmseefNRRSMELYAEQAKDVDIIITTAAIPGKPAPRLITKEMVDSMKPGSVVVDLAAA------ 287  [Haemophilus]...
Q9F3D4        225 aqeesadg----yakatsadyDRAAARLYHEQARDVDVVITTALIPGRPAPRLLTAADVAAMRPGSVVVDMAAA------ 294  Streptomyces ...
Q18031        245 kedgeggg---gyakemskefIDAEMKLFADQCKDVDIIITTALIPGKKAPILITEEMIKSMKPGSVVVDLAAE------ 315  Caenorhabditi...
Q6NYQ7        275 kesgegqg---gyakemskefIEAEMKLFAKQCLDVDIIITTALIPGRKAPVLITKEMVETMKDGSVVVDLAAE------ 345  zebrafish
2VOE_F        271 Q-GGCFEgsrPTTYDHPTFAVHDTLFYCVANMPASVPKTSTYALTNATMPYVLEL---ADHGWrAACRS------NPALA 340  Mycobacterium...
Q8IKU3        938 NwGGNIE---CSQSNENILI-NGVHVLGRDKIERNMPMQASDLFSMNMINLLEEMg--GGVHF-NIDMN------NDIIK 1004 Plasmodium fa...
Q24858        853 N-GGNCE---VTRSGETYLYDNRITIIGQTDYTVKMSPQASQLYSQNIFNFLNLIc-kKASDF-TIKLE------EPIVR 920  Entamoeba his...
P73496        309 Q-GGNCE---VTKPGEVYEY-EGVTIIGYTDLPSRMASQSSQLYGTNLWHLLKDMg--GSEAF-KVDVE------DEVIR 374  Synechocystis...
WP_010972360  293 R-GGNCD---LTVPDQRIVSDNGVIVIGYTDFPSRMAAQASTLYSTNIRHMMTDLtpaKDGKP-VHNME------DDVIR 361  Agrobacterium...
1X15_A        295 N-GGNCE---YTVPGEIFTTENGVKVIGYTDLPGRLPTQSSQLYGTNLVNLLKLLckeKDGNI-TVDFD------DVVIR 363  Escherichia coli
Q7VL24        288 T-GGNCD---YTKAGEVVITDNQVKVIGYTDFPARLPTQSSQLYGTNLVNLLKLLtpnKDGQI-AINFD------DVVVR 356  [Haemophilus]...
Q9F3D4        295 Q-GGNVE---GTVAGRTVVTGNGVTVIGYTDLAARLPAQASQLFGTNLVNLLRLLtpgKDGRI-VIDFD------DVVQR 363  Streptomyces ...
Q18031        316 S-GGNIA---TTRPGEVYVK-HGVTHIGFTDLPSRLPTQSSELYSNNIAKFLLHLg--KDKTF-FVNEE------DEVAR 381  Caenorhabditi...
Q6NYQ7        346 A-GGNIE---TTVPGELSVH-KGVIHVGYTDIPSRLPTQASTLYSNNITKLIRAIspdKETFYfDVKNEfdfgtmDHVIR 420  zebrafish
2VOE_F        341 KGLSTHEGALLS 352  Mycobacterium tuberculosis H37Rv
Q8IKU3       1005 SLVVIKDGNILY 1016 Plasmodium falciparum 3D7
Q24858        921 QMVVCSAGQKMW 932  Entamoeba histolytica
P73496        375 GALVSHEGKITW 386  Synechocystis sp. PCC 6803
WP_010972360  362 GATVTYQGEITF 373  Agrobacterium tumefaciens complex
1X15_A        364 GVTVIRAGEITW 375  Escherichia coli
Q7VL24        357 GVTVIRDGEVTW 368  [Haemophilus] ducreyi
Q9F3D4        364 TVTVVRAGTVTW 375  Streptomyces coelicolor
Q18031        382 GALVVRDGQMKW 393  Caenorhabditis elegans
Q6NYQ7        421 GSVVMQDGKVLF 432  zebrafish
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