3JYG,2G64


Conserved Protein Domain Family
PTPS

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pfam01242: PTPS 
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6-pyruvoyl tetrahydropterin synthase
6-Pyruvoyl tetrahydrobiopterin synthase catalyzes the conversion of dihydroneopterin triphosphate to 6-pyruvoyl tetrahydropterin, the second of three enzymatic steps in the synthesis of tetrahydrobiopterin from GTP. The functional enzyme is a hexamer of identical subunits.
Statistics
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PSSM-Id: 460129
Aligned: 87 rows
Threshold Bit Score: 78.7772
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3JYG_F          6 QIAKEFDFCYGHRVW-SQElnpdfsldpcLSCRHLHGHQGKVIVHLESR-ELQRGXVTDFAHLNWFKRF-IDEVLDHRFI 82  Wolinella succ...
jgi:Hhal_1116 144 TIWKAQRFEAATCVA-DAD----------DTRARLHGHGYRLRVHVTAPlDRVLGWTLDYGDVKAAFAP-VREALDHQRL 211
Q3SGI3          2 DIFRIFHLQCARRLP-ALPa--------sHRCSRVHGHSFEVELTVSGEvDARLGWVCDFAEIEAAWRP-IHEALDHRYL 71  Thiobacillus d...
Q8F965          5 eLTKEFRFDAAHLLP-NVPd--------gHKCKRLHGHSFRFKLHLKGTiDPKTGWLIDYAAVSKIVKPlIENHLDHYYL 75  Leptospira int...
jgi:Plav_3150   2 KIYKEFLFDAAHFLP-YAEe--------gHPNRRMHGHSFRVVVWLKGKpAAETGIVRHFEDVEREIMA-VREKLDHHLL 71 
Q0BPQ0         13 EIGKQFTFEAAHTLHrEIEt---------DSSLRIHGHSYRVEVVLRGGvDPDSGMLMDLGLLQRKMNA-VRDALDHRLL 82  Granulibacter ...
Q1GPS3          3 ELSKQFRFDAAHTLErSIDt---------ESSRRIHGHSYRAEVTVRGRpDPATGMIVDLGLLERSMED-ARDALDHRFL 72  Sphingopyxis a...
WP_011809015    4 TISQRFFFDAAHTLR-REIe--------aEGSRRVHGHTYHAEVALTGAcDPATGMVLDLGLLRQGLER-VRAQLDHHML 73  Verminephrobac...
jgi:Mpe_A0527   3 ELSQSFYFESAHTLRrQVErn------eaDGSRRVHGHTYTAEVTVRGEaDPATGMVVDLALLRSAIAT-VREQLDHHFL 75 
Q1QIG8          3 ELTKSFRFEAAHSLP-GTTf--------gAASMEIHGHSFRAEVSVRGTpDPATGMVLDLGLLERGMGE-VRNKLDHKLL 72  Nitrobacter ha...
3JYG_F         83 iDiDDPLFptllphfadksalvwxeegyarvdferikgesspilelyesfvvvrfvPTSESIASWLLELLRSRIqplGVK 162 Wolinella succ...
jgi:Hhal_1116 212 -D-TIAGLes----------------------------------------------gDVASLAAWAARAARQRL----PE 239
Q3SGI3         72 -N-DVDRLd----------------------------------------------nPTSERLAIWLWAQLKPSL----PG 99  Thiobacillus d...
Q8F965         76 -N-DVPGLe----------------------------------------------nPTSENLSIWLWNHLKPLL----PL 103 Leptospira int...
jgi:Plav_3150  72 -N-EIEGLe----------------------------------------------fPTLERIAAWIWDALATPL----PE 99 
Q0BPQ0         83 -D-EVPGLa----------------------------------------------pATMENIALFIWRHLAPDL----PA 110 Granulibacter ...
Q1GPS3         73 -D-EINDLg----------------------------------------------pATMENLSRWIWNRLSPEL----DN 100 Sphingopyxis a...
WP_011809015   74 -D-DVPGLg----------------------------------------------pPTLENLCVFIARALPDEL---RWR 102 Verminephrobac...
jgi:Mpe_A0527  76 -D-EVPGLg----------------------------------------------lPTLENLCRFIHERLLTTV----PA 103
Q1QIG8         73 -N-NVEGLg----------------------------------------------pPTLENLARFIWDHVQPAG-----Q 99  Nitrobacter ha...
3JYG_F        163 VSSVEFLE-TPKSRARVYNE 181 Wolinella succinogenes
jgi:Hhal_1116 240 LLRVDCYE-RDGVGAIAWPE 258
Q3SGI3        100 LSQIRVME-THDSGCIYRGE 118 Thiobacillus denitrificans ATCC 25259
Q8F965        104 LYKITLNE-TCTSACIYEGp 122 Leptospira interrogans
jgi:Plav_3150 100 IARVEVHRaSCREGCIYDGP 119
Q0BPQ0        111 LAEVSVFRdTLGERCTCRGA 130 Granulibacter bethesdensis CGDNIH1
Q1GPS3        101 LFKVSVYRdSSGDACTYWGE 120 Sphingopyxis alaskensis
WP_011809015  103 ASRVRVWReALGDGCTLDLP 122 Verminephrobacter eiseniae
jgi:Mpe_A0527 104 IASVSVGRqSSGDRCTFRPV 123
Q1QIG8        100 VTRVSVHRdSCGESCTYFGP 119 Nitrobacter hamburgensis X14
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