4I70,2C40,3T8I,3T8J,3FZ0,4KPN,1Q8F


Conserved Protein Domain Family
IU_nuc_hydro

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pfam01156: IU_nuc_hydro 
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Inosine-uridine preferring nucleoside hydrolase
Statistics
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PSSM-Id: 426086
Aligned: 671 rows
Threshold Bit Score: 54.7421
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4I70_A         5 VILDHDGN--KDDFVAMiLLLsNPkkV-NLIGCICTDADCFVENGFDVTGKIMcAMHRlikTPlFP-----IGkstatav 76  Trypanosoma bru...
Q029F1        22 VIFDTDSGlfGDDGAALvMLLrGSsqE-VLQGITIVPGNVWAAQGAEYMFHILdLLk-------KPqmqvaVGaeaplih 93  Candidatus Soli...
Q9HGL1        27 VIIDNDGLt-----dLQvLFA-LQa-KqQILGVTAIYGDYTLDDSLFLASDVLsTGNL---TYcIPs---fAGaaqpllr 93  Schizosaccharom...
Q6BSS3        26 IFIDNDGAt-----tPDvLIP-IFy-GyEILGYSASFGSSSLVDSVGATYNVLdMLNM---TKcIPl---yVGannplir 92  Debaryomyces ha...
XP_011275123  21 IFIDNDGLa-----sLEaLFA-ISa-GyEIVGVSSSFGSSSLVDSAGAASDVLkTYNL---TScIPn---yLGaqqpllr 87  Wickerhamomyces...
XP_001386814  22 VFIDNDGLa-----pLQvLFP-LLa-GwEVLGISTSFGSSSTVDSAGAAYDVLtAYNL---TScIPh---yVGaqqpllr 88  Scheffersomyces...
EER35708      18 VFIDNDGLs-----aLQvLFP-LKa-GwEIVGISGSFGSSSAVDAVGIGSDILeTYNL---TAcIPh---yLGaqqpllr 84  Candida tropica...
EGV65217      41 VFIDNDEAn-----tPTiLIP-LFa-GwEILGVSGSFGSSSYVDSVGSHATILeNYSL---DScVPl---yGGaskpflr 107 Yamadazyma tenu...
EPE08257      22 VFIDNDGLn-----gLQlLIP-LYg-GyEIVGLSMSFGSSSSADSLGTAYDVLtTYNM---TScIPl---yLGaqqpliq 88  Ophiostoma pice...
EFX06335      22 VFIENDGLn-----aLQlLLP-IYg-GyDVVGVSMSFGSSSSADALGSAYDVLtTYNM---TScIPl---yLGaeqpliq 88  Grosmannia clav...
4I70_A        77 nafptewrfsaknlddmpflnived----valweklkpeneahngqqlladlvmkskekvtVCVTGPLSNMAWCIEKyGE 152 Trypanosoma bru...
Q029F1        94 taamskefdrrwgglgytgafaqdptavvpapgskistrklrrdainfliseierhpgeitILALGPMTNIALALRL-KP 172 Candidatus Soli...
Q9HGL1        94 tnntfqiwqelygsyvwqgywqpeye--tantnnesyiyntqisaaqfiidmvkanpneitIVAAGPMTNLAIALSI-WP 170 Schizosaccharom...
Q6BSS3        93 tndsfhrwedlygtlywqggfspdyq---dmyswadiqyneeipgalalinavkkypgeveVYAAGTMTTVAQALSI-YP 168 Debaryomyces ha...
XP_011275123  88 tnetfhawenlfgdlvwqgafdasyad-shswdnvtyddskagalalieavksnkdsdpvtIFAAGMMTTVAQAISI-YP 165 Wickerhamomyces...
XP_001386814  89 tqdtfdtwqslfgelvwqgafapsyed-lyswdnityndsvpgavalieavkankdtdpvyIYAAGMMTTVAQAISL-YP 166 Scheffersomyces...
EER35708      85 tqetfdtwqdlfgslvwqgafthgyed-sytwdnityddskagavamieavrahkdtdpvyIWAAGMMTTVAQAISL-YP 162 Candida tropica...
EGV65217     108 tnetfhvweqlygtlvwegawspyytd-sytwkdfsynetlpgaiamieavkaykdsdpvtIFAAGTMTTVAQAISI-YP 185 Yamadazyma tenu...
EPE08257      89 tndtfhlhntlfgapvwqgaftpgyv--dsydinnityndtpgalalidavkkykdtdpvmIWAAGMMTTVAQAISI-YP 165 Ophiostoma pice...
EFX06335      89 tnetfhlhntlfgapvwegaftagytd-synisdipysadvpgalalidavrsnkdtdpvmIWAAGMMTTVAQALSI-YP 166 Grosmannia clav...
4I70_A       153 AFtSKVEECVIMGGAVD--------------VGgnvflpttdgsAEWNIYWDPPAAKKVLccpnircVLFSLDATNtvPv 218 Trypanosoma bru...
Q029F1       173 DIeTKIKRIVFMGGNIRvag--------natPA-----------AEFNFWFDPEAARIVLrsripkkMMFGLDICNlaKi 233 Candidatus Soli...
Q9HGL1       171 DLaKNTKSLVIMGGYVDsqiaqvtggdflndMY-----------SDFNLFMEPEAAQTAItadwpelIIAG-NITs-qVy 237 Schizosaccharom...
Q6BSS3       169 DLvEDAAGLTIMGGYIDgqyvsavegglvsdLF-----------SDINLIQDPEAAQIALtapwksvTIAG-NITn-sLf 235 Debaryomyces ha...
XP_011275123 166 NLvKEAAGLYIMGGYFDnqyaqatgnsitidIN-----------TDINLIQDPEAAQIVLtsdwkelVIGG-NFTn-yLv 232 Wickerhamomyces...
XP_001386814 167 DLvKDAAGLYIMGGYFDqqfaagtgtpivndIN-----------TDINLMQDPEAAQIVLtanwtelYIGA-NVTn-yLv 233 Scheffersomyces...
EER35708     163 NLvNESAGIYIMGGYFDtqyaaasgppivndIN-----------TDINLIQDPEAAQIVLtaawkhlVIGA-NVTn-yLv 229 Candida tropica...
EGV65217     186 NLvKEAAGLYIMGGYIDvqyahaagssfqddLV-----------SDINIIQDPEAAQMVLtadwkkiIIGG-NVTn-aEt 252 Yamadazyma tenu...
EPE08257     166 KLvEEAAGLYIMGGYVDtqmaqatgnafqvdVN-----------TDINLIQDPEAAQIVLtagwkelYIGG-NVTn-yLv 232 Ophiostoma pice...
EFX06335     167 KLvEEAAGLYIMGGYIDtqyaqatgsafqvdVN-----------TDINLIQDPEAAQNVLtagwkelYIGG-NVTn-yLv 233 Grosmannia clav...
4I70_A       219 rsvdvkgfgaqnqyllsqmvg---------tmwamstheeilrdgdayyawDALTAAYileptiatlepvaldvdvskg- 288 Trypanosoma bru...
Q029F1       234 rkaefdqiasarnpiaelfr----------edlgnrypgflkkpdaigfmwDSLAAAYlldpdfvtktesryldvqttwg 303 Candidatus Soli...
Q9HGL1       238 psqslyngiiaraggmaniesd------sglsyakqfvgngtlpsgsfpfwDEVASAIaawpeivnssydayvsvdtayd 311 Schizosaccharom...
Q6BSS3       236 httdeyqkiikdlgglgliqsdpk---lqyvkefvgngtaaphgeenlpywDEMAVGFvvnkdlikqsvnisfaidtafd 312 Debaryomyces ha...
XP_011275123 233 psqelydkiidkagsidlirshpy--fsqvsnllatgnytenndqqklpfwDAAILFAlvnpdtikettdvtvavdtsfy 310 Wickerhamomyces...
XP_001386814 234 psqelydrlitkaggysvleensy--lepvlnlvatgnytentseqtlpfwDEVVSAFmvwpdmvqsttnfsvavdtqfy 311 Scheffersomyces...
EER35708     230 psqelynriidkaggldviqdnpy--faqvstmlatgnytentseetlpfwDEVVTAFmvwpdliestssfsvavdtsfy 307 Candida tropica...
EGV65217     253 psqdlydemieraggleeiqespylvgvnetvlsgnytlnsvstenilpfwDSVVSAFmvspeiithktsvalavdtsfn 332 Yamadazyma tenu...
EPE08257     233 psqelydriiekaggldvlnnntyfselqsivvsgnytenaadtenilpfwDEVVSAFmafpdiitsstpvlasvdtsfy 312 Ophiostoma pice...
EFX06335     234 psqalynriikkaggldvinnnsyfaalqdivhsgnysqnanntelilpfwDEVVSAFmafpnlltsttpvqaavdtsfy 313 Grosmannia clav...
4I70_A       289 --------ksegrtprasgegkpcvhvarNPSKQMFHD 318 Trypanosoma brucei brucei TREU927
Q029F1       304 q-----fygsttpldrratptatpvtvmlDLDFKRVFA 336 Candidatus Solibacter usitatus Ellin6076
Q9HGL1       312 spfygslrmvpadlvpkkgvrtakasmitGINVAMFYQ 349 Schizosaccharomyces pombe 972h-
Q6BSS3       313 spfygqlrlwpenlapkkgirigraqlitEVDSDMFLN 350 Debaryomyces hansenii
XP_011275123 311 spyygslklyshewapksgykvanativdKIDDEQFYN 348 Wickerhamomyces ciferrii
XP_001386814 312 spf-ygslriwgsefapkgqitgnativnKIDDSRFYD 348 Scheffersomyces stipitis CBS 6054
EER35708     308 spf-ygnlriwgheyaphgmrtgnativnKIDNDRFYD 344 Candida tropicalis MYA-3404
EGV65217     333 spf-ygtvriwshdraptayktgnvtivdSIDQDKFYD 369 Yamadazyma tenuis ATCC 10573
EPE08257     313 spfygqlriwgadfaptagyktgnativnSIKDAVFYD 350 Ophiostoma piceae UAMH 11346
EFX06335     314 spfygnlriwgsefapsagyrtgnativnSIKKDKFYD 351 Grosmannia clavigera kw1407
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