Conserved Protein Domain Family
Caveolin
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pfam01146: Caveolin 
Caveolin
All three known Caveolin forms have the FEDVIAEP caveolin 'signature motif' within their hydrophilic N-terminal domain. Caveolin 2 (Cav-2) is co-localized and co-expressed with Cav-1/VIP21, forms heterodimers with it and needs Cav-1 for proper membrane localization. Cav-3 has greater protein sequence similarity to Cav-1 than to Cav-2. Cellular processes caveolins are involved in include vesicular transport, cholesterol homeostasis, signal transduction, and tumor suppression.
Links
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Statistics
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PSSM-Id: 426079
Aligned: 33 rows
Threshold Bit Score: 173.153
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_007234243  16 EDLFSRSIEPIltkkeklytpepdrDRDPRDINAHL-KVEFEDIIAEPSSTHSFDSVWIWSHAVFELLKYIFYRLLTTLL 94  Mexican tetra
NP_001096498  19 KDLLTKEIDLV--------------DRDPKRINDSViKVDFEDVIAEPQGTHSFDGVWKASYTTFTVTKFWCYRILSAAI 84  tropical clawed...
OCA24586      17 TEALTKEIDLV--------------QRDPKKINQEVvQVDFEDVIAEPDGTHSFDGVWKASSTTFTVTKYWCYRVFSAIF 82  tropical clawed...
XP_003498141  15 KDIHCKEIDLV--------------NRDPKNINEDIvKVDFEDVIAEPEGTYSFDGVWKVSYTTFTVSKYWCYRLLSTLL 80  Chinese hamster
EFX82628     107 VQTFTVGLNVL--------------DRDEKHINDTI-NLNFEDVLAEPDVAHGFDPIWRAAFILFTGSRFWIYRLLSAIL 171 common water flea
KRX73430      93 QSQMTIGINML--------------DRDEKQLNEHI-KLNFEDILAEPDGYHSWDWVWRGTYHTFNTLRRFIYRFLALLF 157 Trichinella sp. T6
PDM72941      84 KQEMTIGIDMQ--------------MRDEKQINNHV-NIQFDDVFAEPETFHSVDCIWRINHRIFESTRTFFYKVFG-IL 147 Pristionchus pa...
EGT60057      92 DRDQRMGINFV--------------DRDRNNLATNL-DFSFENVFGENKAQHSWEWSYRINHYVYSAFKEIFYKLFQ-WC 155 Caenorhabditis ...
Q94051        93 EENIAIGVDLV--------------NRDANSMNNHV-QLNFEDIFGEADSQHSWDCVWRLNHTVFTAVRLFIYRLVS-LL 156 Caenorhabditis ...
CAP33397      97 EDHIAIGMDFV--------------NRDHNGLNNHV-QHNFDDIFGEADSQHTWEFMWRLNASVFNWVRLFVYRFFT-IL 160 Caenorhabditis ...

XP_007234243  95 AIPMAFVAGIVFGLLSCVHIWVVMPLVHSCMMALPSVQVVWASLMDMFTGPFFHSFGKSLSSINIKTV 162 Mexican tetra
NP_001096498  85 GIPLSIVWGFIFALISFCHIWAVVPCIKSYQIETHCLGRIFSLCTHTFCDPLFEALGKIFSSIKVTLQ 152 tropical clawed frog
OCA24586      83 GLPLALLWGFLFACLSFCHIWAVVPCVKSYLMEVQCLGQFYALCVRTFCDPIFEAIGKVLSGIKVSLR 150 tropical clawed frog
XP_003498141  81 GVPLALIWGFLFACISFCHIWAVVPCIKSYLIEIQCISHIYSLCIRTFCNPLFAALGQVCSNIKVVLR 148 Chinese hamster
EFX82628     172 ALPLALVWGITFSLITFFSVWLATPLLRIMDVFLFYIRRVWVALVQTTLEPVANAVGGCFSNVKLTHN 239 common water flea
KRX73430     158 AVPCAIVWAMLFALLTSINVWILTPLAIAISIPAVWLAKTWNFIIRSLLDPFFKSCGLMRAAHSESPT 225 Trichinella sp. T6
PDM72941     148 SIPIVFIFAILFAFASAVNNFLVMPLAALFTIPLTWIAKTWTFLVSNIFDPVANSIGLCFSKINVRKY 215 Pristionchus pacificus
EGT60057     156 VLPFTVFFAIFVALFVTLYSWILLPLGKLLIIPGTVVAAVWSWLIHAIFDPIFSSLGLLFSNFNIRKY 223 Caenorhabditis brenneri
Q94051       157 ALPFTIIFAIFFGLLASINVFIIVPLGKLLSIPGTLLAKLWNWLIHAIFDPIASAVGLIFSNFNIRKY 224 Caenorhabditis elegans
CAP33397     161 ALPFTLLFAIFFGFFAAVNVFVIVPFGKLISIPGNLLAKLWNWLVHAVFDPVASAVGLIFSNFNIRKY 228 Caenorhabditis briggsae
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