Conserved Protein Domain Family
TruD

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pfam01142: TruD 
tRNA pseudouridine synthase D (TruD)
TruD is responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs. The structure of TruD reveals an overall V-shaped molecule which contains an RNA-binding cleft.
Statistics
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PSSM-Id: 426077
Aligned: 66 rows
Threshold Bit Score: 329.541
Created: 16-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
jgi:Hbor_25520        10 RVGIEHYVSDAEGTGGRLRDAPEDFRVREVea--mDAvdV---DEDP----------GDYpsLLLRVTLREWDTNDFARR 74  Halogeo...
WP_011752352          12 lLGLEYYGLDGAGTGGKLRSSLDDFIVREIsidgeVAspEckyAEGA----------GEF--TWLVLEKRKIDTVSAARA 79  Thermof...
Q8ZTR2                10 MLGMFYYATDTCPSGGVIKRSPEDFVVEEVlldgtVI------ATSGvelr---prvGNW--TWIHVVKRNVDTIKLVLR 78  Pyrobac...
CCC82250              14 SLGIELYMTDTEPCGGRIKERPEDFIVEEVlegghLIaiSgaeLPRSr--------pGPW--LLVHVVKRDVDTLKLIEE 83  Thermop...
WP_013337324          12 FVGMNYYVTDCEGIGGRIKERLEDFIVEEVlidgqVVp----tGITGkplpkivskpGPW--VWMIIEKRGIDAITLSLV 85  Vulcani...
jgi:Cmaq_1576         12 QVGMEYYITDCGGVGGRLRSSYEDFIVEEVlidgmVIslKapvNIKPk--------pGPY--TWIIIEKRGIDTISLVVT 81  Caldivi...
goetting:Ngar_c26260  11 laGIECYCTSFAGTGGSIKQRSEGFRVSELvdellVGniSltfD-------------NRHryPLYILEKHDIDSNHALFE 77  Candida...
jgi:Gura_0971          1 -mlKTYLTADLPGTGGTIKETPEDFLVAEIplylpCGe-------------------GEH--TFAEIEKRGITTLEALRR 58  Geobact...
ACH39780              21 galsiYLTAEVPGTGGTIKGSPEDFLVEEIpaylpSGq-------------------GEH--CFAVLEKRGIATLEALRR 79  Geobact...
BAM04297               5 pshvPMLTADLPGTGGVLKERPEDFTVDEQplyepSGa-------------------GEH--LYLFVEKREATTAQAIKA 63  Phycisp...
jgi:Hbor_25520        75 LSDALGISRERVSWAGTKDKYAVTTQLFS---V-RD--ASPDEIP--AI---NNADIEVLGRIGRDLGFGDLAGNDFDVR 143 Halogeo...
WP_011752352          80 VARFFGLKLRDVGIAGLKDTSAVTYQFIS---IpGE--VKMESIEefNLs-hKRVKLHCPFRRPFALKPGMLYGNFFNVK 153 Thermof...
Q8ZTR2                79 LARALGLSHRDVSVGGLKDTKAVTSQIIS---V-RGpvANLPQLPg--------VQFLGMWSMDKPITPSQIYGNRFTII 146 Pyrobac...
CCC82250              84 LRKTLKLKGDEIKIGGIKDARAVASHVIS---L-YK--IRPEDLPr-----iPGVVYKDFAYADAPITPARIEGNKFTVV 152 Thermop...
WP_013337324          86 ISRKLGVNYRDVSFGGLKDAIAVTSQVVS---V-RG--VSINEVPnd---fgRDIKVLNAVSMDRAFTTSDIWGNEFTIK 156 Vulcani...
jgi:Cmaq_1576         82 LSRRLGVKLSDVSYGGLKDTKAVATQVIS---I-KG--ITPMQLEgld--lgPRVRVVASFSMDKPFTPSEIWGNQFTIV 153 Caldivi...
goetting:Ngar_c26260  78 IERECRM---RLRVMGIKDAKAVTTQYASadrVmRNppGELKT---------KHTRLTLEGFTRRPLGKEFLAGNKFEIT 145 Candida...
jgi:Gura_0971         59 LAKALGIAERDMGYAGMKDARGVTRQTFS---I-PR--VAPDRVLglEV---QGIRVLSASLHRNKLKLGHLRGNRFRLR 129 Geobact...
ACH39780              80 IAKTLGVQERDLGYAGMKDAIGVTRQTVS---I-PR--VAPDKVLalEI---PGIKILSARMHGNKLRLGHLKGNRFVIR 150 Geobact...
BAM04297              64 VAKAFRVPQRAIGHAGLKDKHAVTRQHLSvwlP-GPpdPTAEEACiaRVnhhPKLHVHWAERHGNKLRRGHHGGNRFGIK 142 Phycisp...
jgi:Hbor_25520       144 VRD--ADASA---NAATVTAQLQAfltdedavdgaategetaavaVP--NYFGHQRFGSRRPVTHEVGLHVVRGEWCEAV 216 Halogeo...
WP_011752352         154 VRGa-----EcleCLEALLRELKEkk------------------aVP--NYYGYQRFGTVRPVTHVVGRMILLGEFKEAV 208 Thermof...
Q8ZTR2               147 LRDv-----ErisCAEGALEALKKt-------------------aAP--NYYGYQRFGTIRPVTHLLGKALLKKDPHLFF 200 Pyrobac...
CCC82250             153 IRE------TdcgCALKTAELLRN---------------------VPiaNYYGYQRFGTIRPTSHLLGRALVKRDPEEFL 205 Thermop...
WP_013337324         157 VRNidV---SrkdSINCVINQLMEr-------------------gLP--TYYGYQRFGLKRPNSHIIGKHIIFGEFEEAV 212 Vulcani...
jgi:Cmaq_1576        154 IRGitGDES----VFNCVIEQVMEr-------------------gLP--SYYGYQRFGLRRPNSHIIGKLIIMGDFEKAV 208 Caldivi...
goetting:Ngar_c26260 146 IHR------PrshDLSGLLPEIDK---------------------VG--NFYGLQRFGSERLVTHLVGREIVKRNFRRAV 196 Candida...
jgi:Gura_0971        130 VRGvtA---DavpSASAVLSVLAKr-------------------gVP--NYFGEQRYGT-QGNSHLIGAALLRGDYRGAV 184 Geobact...
ACH39780             151 VRDvaQ---GavkNAEAALEVMTRr-------------------gVP--NRFGVQRYGA-QGNTHEIGAAMLRREFKSAV 205 Geobact...
BAM04297             143 IRGvgP---AavlRARPILDRIAEr-------------------gLP--NAVGPQRFGF-RGNAHTLGKLLLQNDPDAFL 197 Phycisp...
jgi:Hbor_25520       217 LSYVGNPASAEPDGTQAARRFVdeqaaSDDPDWHAALETMPNRLRY--ERSMLHRLAEdgdeSAEDWRHALEAVPRNLQR 294 Halogeo...
WP_011752352         209 EELIYKVFPGESQVSRRARLFL-----SESGDPLKALELFPKSLKS--ERAVLRHLAR----HPGDYVGALRAVSPYVKK 277 Thermof...
Q8ZTR2               201 EVMFCKIFSRESEVAKRAREAAc------KGDYAKALELFPKKFVE--ERVFLKRLAG-----GYDMWNAIMAIPPQILR 267 Pyrobac...
CCC82250             206 NVMFCKIFEGESELVKEARLLAc------RGDYDKALEKMPKSMLE--ERALLKALSS-----GQSLWNAIAAIPRNILK 272 Thermop...
WP_013337324         213 NELLTHAYPMEPPRIREVREFI-----ARTGDYSKALELMPRSYRYypERAVLKQLAS----NPRDFVNALRKLPHELLN 283 Vulcani...
jgi:Cmaq_1576        209 EELVAKPYPYEDDTIRKARE-L-----AGMGEYSKALELLPRSIRYlpERLVLKQLLM----DPGNYMNALSKLPVNLLK 278 Caldivi...
goetting:Ngar_c26260 197 ELLLSYTTEYDTPASKEIRSKS-----ADPGNYRQVLRILPRGMDI--ERQVLTALVA-----GKDAVSALRTVPITIRR 264 Candida...
jgi:Gura_0971        185 DALIGDAAKVTDERWRAAIEAY------RRGDPDESLRAFPGHCRT--ERDLLQRLVK----QPDDWEKAFRAVHPRLKK 252 Geobact...
ACH39780             206 DRLIGDPAAVTDERWRQAIEAY------RRGEVEESLALFPGHFRV--ERELLTRLVQ----RPDGFERAFNSVQPRMKR 273 Geobact...
BAM04297             198 AELLGVDGVQENPRLTAARAAY------RRGDLVAAIEGWPKSLPH--ERQALDNLRQ-----GHTPERAVRALARTQRD 264 Phycisp...
jgi:Hbor_25520       295 LFVNAAQSYVFNRILSERLDRGLPLTRPIEGDVVCFA-DRdvpdrlyradpdrTQVATGRRVEVMSRHCERGRAFVTAPL 373 Halogeo...
WP_011752352         278 LFIGAYQAYLFNKLLSKRIERGLSYYYPVPGDTVGIFrEKrgge------vtgVLKVNDANVEKVKRWIDEGFAVLLLPV 351 Thermof...
Q8ZTR2               268 VYIEAAQSYIFNRFLSIRMEIG-PIDRPVEGDLVEINrQ-------------------------IAYYAEGLGGEVVLPV 321 Pyrobac...
CCC82250             273 IYLEAYQAYLFNRMLSLRLREGIA---TMPDDLVMLGnYP------------------------ILASHAGGAGIPVLPV 325 Thermop...
WP_013337324         284 LYVESYQSYLFNLALSERIGRGLPINKALPGDAVALLdEHglp-------tkhVIYVNESMVDKVNELIMRGRAVPVGHL 356 Vulcani...
jgi:Cmaq_1576        279 LYVEAYQSYLFNKALSARIGRGISINRAVDGDLIVLLdEHglp-------tgnVIKAEGSMVDKVNSIISKGRATVVGHL 351 Caldivi...
goetting:Ngar_c26260 265 LFVQAYQAYIFNKCLSTAVINGEDLLQPAAGDLCFEMeGP----------------ATFGRIIKYDHASKAKKMVPAIRM 328 Candida...
jgi:Gura_0971        253 LYLSAFQSFLFDRLLDGRLD---RLDEVVDGDVAYKHdNGa------------CFLVTDAAAEAVR--AEAFEISPTGPL 315 Geobact...
ACH39780             274 LYLSAFQSSLFDLVLEKRLD---SFDKVNVGDIAFKHeNGa------------RFLVQDLAAEAPR--AEAFDISPTGPM 336 Geobact...
BAM04297             265 FLASALQSAVFNRVLARRLNAG-TWDRLIDGDLAWKHeNRatf-------pvdAAVAATENAEGGR--VGGFAVSPSGPL 334 Phycisp...
jgi:Hbor_25520       374 VGTETELAEGEAGEIERAVLNELDLEPADFD-LPG--EFD-STGTRRAVLLRTDvettvdSDAd---------tYELTFS 440 Halogeo...
WP_011752352         352 FGYNSNLSHGVVGEIERELLREEGIDVSMFR-VKQipEAS-SAGTYRYASLVPH------ALNvrvf----gndYELTFV 419 Thermof...
Q8ZTR2               322 VGAGVRMPRGKVGEALLRVLREEGLDPSAFLkMPR--GLR-VYGTYRRVRLEPA------GFEykim----gndVFMQFT 388 Pyrobac...
CCC82250             326 PGAGIVVPESRAREYLRKILREEGLELQDFAaV----RVS-VSGSYRRVFVEPR------DLAysck----ggeMTISFI 390 Thermop...
WP_013337324         357 VGYNTKLPPGLQSDIELDVLRREGVDLSMFM-VKSipKLS-IRGGYRPLFTKPI------IIStnla----ndgLNIVFR 424 Vulcani...
jgi:Cmaq_1576        352 VGYRSRFNNGVQGEIELSVLKAEGIEPSDFK-VSGmpKLA-TGGGVRWLSIKPI------IHSisvn----gsnAKLIFK 419 Caldivi...
goetting:Ngar_c26260 329 AGYTFQPGKGRFENITKAILQEEGVTAKDFY-VKEmqELS-HQGGFRQAPLWCM------DFSysk-----npqLIVSFK 395 Candida...
jgi:Gura_0971        316 FGCKMKEPEGKVLELERQVLDMEGLSLESFN-LTG--GLR-MEGERRPLRVPLM------EPTaewd----gegLVLEFG 381 Geobact...
ACH39780             337 FGCTMMEPHGAQGELEREVLAAQELTLESFN-LSG--GLR-MEGERRPLRVPIA------GADvqqe----gsdLLVGFS 402 Geobact...
BAM04297             335 PGPDCQPAEREALAVEDAALAELDLERSLFDgGT---PLAdAGGARRPLRVPVG------DVTyaaggdehgpyLSVSFE 405 Phycisp...
jgi:Hbor_25520       441 LPSGSYATALLREY 454 Halogeometricum borinquense DSM 11551
WP_011752352         420 LNKGAYATTLLREL 433 Thermofilum pendens
Q8ZTR2               389 LPRGSYATVLLREV 402 Pyrobaculum aerophilum str. IM2
CCC82250             391 LPRGSYATLILREI 404 Thermoproteus tenax Kra 1
WP_013337324         425 LPRGNYATVFLREL 438 Vulcanisaeta distributa
jgi:Cmaq_1576        420 LPKGNYATTLLREF 433 Caldivirga maquilingensis IC-167
goetting:Ngar_c26260 396 LPKGSYATTLLREI 409 Candidatus Nitrososphaera gargensis Ga9.2
jgi:Gura_0971        382 LPRGSYATAVLREV 395 Geobacter uraniireducens Rf4
ACH39780             403 LPRGAYATCVMSEI 416 Geobacter bemidjiensis Bem
BAM04297             406 LGRGVYATAVMAEV 419 Phycisphaera mikurensis NBRC 102666
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