3KGD


Conserved Protein Domain Family
RTC

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pfam01137: RTC 
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RNA 3'-terminal phosphate cyclase
RNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organizms. They catalyze the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of RNA, in a reaction involving formation of the covalent AMP-cyclase intermediate. The structure of RTC demonstrates that RTCs are comprised two domain. The larger domain contains an insert domain of approximately 100 amino acids.
Statistics
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PSSM-Id: 460079
Aligned: 157 rows
Threshold Bit Score: 248.195
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3KGD_A          31 QGEGGGQILRSALSLSMITGQPFTITSIRAgraK----PGLLRQHLTAVKAATEICGATvegA-EL---GSqRLLFRPGt 102 Escherichia c...
CBI35040         7 MKLKGSQNLRLRLLLATLSATPVLIDDIRH---Ddt-wPGLRPYEVSLLRLFEKICDDC---VvEInetGT-KLKYKPG- 77 
Q9C578           5 KKMKGSQSFRQRLLLSTLSSTPISIDEIRA---Det-iPGLRPHEVNLLRLLEIVTDDA---VvDInetGT-RLKYKPG- 75  thale cress
Q75LH9           7 RRLSGSRHFRQRVVLATLTSTAITIDDIRS---Gga-aPGLRPHEVSLLHLLHKISDHH---SlDLnetGT-KLRYKPG- 77  Japanese rice
XP_004981151     7 RRLSGSRHLRQRLVLATLTSTTITIEDIRS---Gda-aPGLRPHEVSLLHLLEKISDRH---DiDInetGT-KVRYHPG- 77 
Q09870           7 KRFKGCEYLTHRLVLATLSGTPIRVEGIY----PdeadPGVKDYQVSFLRLLEKLTNGS---ViEIsytGT-SFIYRPG- 77  Schizosacchar...
Q6CHS3           9 IHFSGHNNFRRRLVLATLSGMPVRIDKIR----SddvePGVKDYEVSFLRLLESITNGS---VfEIsytGT-TVVFKPG- 79  Yarrowia lipo...
ESW98510         8 ITFQGHKNFRNRLVFATLSGKTIKIEKIR----SddlnPGLKDYEISLLRLIENVTNGS---ViEIsytGT-TVVYRPG- 78 
XP_003955091     8 ITFQGSQNFRIRIVLATLSGKSIKIEKIR----SndlnPGLRDHEISFLRLIESVTNGS---HiEIsytGT-TVIYKPG- 78 
ybcl:Ecym_3043   6 VTFQGALNFRHRIVMATLSGKAIKIEKIR----SddlnPGLKDYEVSFLRLIDGVTNGS---VvEIsytGT-TVIYKPG- 76 
3KGD_A         103 vrggdyrfaIGSAG-----------SCTLVLQTVLPALWFAdgPSRVEVSGGTDNPS-APPADFIRRVLEPLLAK-IG-I 168 Escherichia c...
CBI35040        78 ---------IIMGGknlvhdcgvgrSIGYFLEPLIVLGLFGkkPLSITLKGITNDSK-DPSVDTFQSTTLSILKH-FGvP 146
Q9C578          76 ---------TIVGGknlvhscslsrSIGYYLEPLLLLGLFGkkPLSIRLKGITNDPR-DASVDTFRSTTLNIIKR-FGvP 144 thale cress
Q75LH9          78 ---------VIVGGrdlehdcgvhrGIGYFLEPLILLGLFAraPISIRLKGITNDTK-DPSVDTFRMVTLHMLKQ-FGvP 146 Japanese rice
XP_004981151    78 ---------KILGGkglehdcgvhrGIGYFLEPLILLGLFArvPISIRLKGITNDTK-DPSVDTFRMTTLHMLKH-FGvP 146
Q09870          78 ---------NIIGGrvvhd-cpttkGIGYFLEPILILCLFAktPTSLTLTGVTSSNE-DIGVDVLRTSVLPSLQKrFQvG 146 Schizosacchar...
Q6CHS3          80 ---------IIVGGsvthn-cplsrGVGYFIEPLLLLAPFGkkALTATLRGITSH-SlDPSPDSIRTSVFPVMQK-FGiE 147 Yarrowia lipo...
ESW98510        79 ---------LIIGGdfvhq-cpdgvACGYFIEPMLCLAPFSknKFSILFKGLTAS-KeHVGVDFIKWGLLPVMEK-FGvR 146
XP_003955091    79 ---------IIVGGshthn-cppsrAVGYFIEPMLYLAPFSkkKFSIIFRGITAS-HnDAGVEAIKWGLLPVLEK-FGvR 146
ybcl:Ecym_3043  77 ---------IIVGGsythn-cpnskPVGYFVEPLLYLAPFSkkKFSIVFRGMTSS-HgDAGVETIKWGLMPVMEK-FGvR 144
3KGD_A         169 H--QQTTLLRHGFYPAGGGVVATevsp-vasFNTLQLGERGNIVQMRGEVLLAGVPRHVAEREIATLAGSFSLHEQNIHN 245 Escherichia c...
CBI35040       147 SegLKLTIRNRAPPPHGGGEVELkipivqnsLTAVTWIDEGMVKRIRGLTFTSRVSSQFEHTMRYAARGIFNRLLPDVHI 226
Q9C578         145 AedLELKIEARGVAPNGGGEVLLtvpn-iktLSAVHWVEEGMVKKIRGTTFSTRVTSDFEHSMRFAARGIFNNLLPDVHI 223 thale cress
Q75LH9         147 LegLELKIESRGAPPLGGGEVFLrvpnikstLKAANWADEGMVKRIRGVSFSTRVSPQIENRIIYAARGIFNRFIPDVHI 226 Japanese rice
XP_004981151   147 LegLELRIDSRGSPPLGGGEVFLrvpningtLTAANWVDEGMVKRIRGVSFSTRVSPQIENRIIYAARGIFNRFIPDVHI 226
Q09870         147 De-LELRILKRGSAPGGGGEVNFlcpvikesLPPIRLSEFGRVFRIRGIASSTRVSPAFANRLVESARGVLNPFIPDVFI 225 Schizosacchar...
Q6CHS3         148 R--QELKIIQRGATPLGGGEVMLhlphlvlhPKTLHATTTPTISKIRGIAYSCRVSPASVNRLIDGAREELRATGCETFI 225 Yarrowia lipo...
ESW98510       147 E--VELHTLKRGSPPLGGGEVHLivnslipqPVTIHVLDYQKISAIRGIAYCTRVSPSVANRLVDSARSVLKATGCEVNI 224
XP_003955091   147 E--CALHTLKRGSPPLGGGEVHLivdsliaqPLTMHELERPPIKSIRGVAYSTRVSPSLVNRMIDGSRNVLKDINCEVNI 224
ybcl:Ecym_3043 145 E--CALHTLKRGSPPIGGGEVHLvvdsliaqPITMHALEKPVISAITGVAYSTRVSPSMVNRMIDAAKSVLKKVPCEVNI 222
3KGD_A         246 LPRD-----------------------QGPGNTVSLEVESENITERFFVVGEKRVSAEVVAAQLVKEVKRYLASTAAVGE 302 Escherichia c...
CBI35040       227 STYHsktgkspgygi--svvaettsgcFISADTAVSYGRGEESGEDKDEENNELMPPEEVGEQIASVLLGEIEQGGVVDS 304
Q9C578         224 FQDHragaqagkspgygislaaetttgCFISADTTVSCERPDETGELDVEKKERSPAEDTGVEVASWLLQEIEKGGVVDS 303 thale cress
Q75LH9         227 FTDHrsgsaggrsag-ygvsvvaetttGCLLSADATVSYPNVDEMNEESENLELTSPEDLGVQVASMLLEEVAQGGVVDS 305 Japanese rice
XP_004981151   227 FTDHrsgsaggrspg-ygvslvaetttGCLLSVDATVSYPSVDEMNEESEKPELMSPEDLGVQAASMLLEEVAQGGVVDS 305
Q09870         226 YTDVrrgd---------------ecgnSPGYSITLVAETNKGCSYAAEHCGEAGETPEDVGSFCAKKLLEVIESGGCVDP 290 Schizosacchar...
Q6CHS3         226 FSDVargd---------------esgkSPGFGIVLVGETRPGFCISAESVAVAGSIPEDLGRETAKKLIEEISRAGVFGR 290 Yarrowia lipo...
ESW98510       225 TTDVcrgei--------------agksPGFGLTLFTESKKIPFRYVVEDIGTGGETPEDVGERVALSLLEQIDTSGCLGR 290
XP_003955091   225 TADVwrge---------------nsgkSPGWGITLVGETKKGWCFFSELIGDAGDIPENIGMQVAYHFIEEISKSAAVGR 289
ybcl:Ecym_3043 223 TADVwrge---------------nsgkSPGWGLTLVGETKKGWRYSAEAIGDGGDVPEDIGTKVAYELLEEISKCGVVDR 287
3KGD_A         303 YLADQLVLPMALAG---------AgeftvAHPSCHLLTNIAVVERFLPVRFSL 346 Escherichia coli str. K-12 substr. MG1655
CBI35040       305 THQGLLFLLCALCPqdvsk-------irvgKLSPNGIETLRHIRDFLGVKFVI 350
Q9C578         304 THQGLLFLLCALSEqdvsk-------vrvgTLSPYAVETLRNIKEFLGVKFAI 349 thale cress
Q75LH9         306 AHQGLLFILCALSPpdvsk-------vrvgQLTPYAIETLRNIRDFLDVKFII 351 Japanese rice
XP_004981151   306 THQGLLFILCALCPpdvsk-------vrvgQLTPYGIETLRNIRDFLGVKFVI 351
Q09870         291 YTQPSTLTGMLLSSedvntivvgQ-----LGITSQLVVFLRDVKALFNCEYRF 338 Schizosaccharomyces pombe 972h-
Q6CHS3         291 NQLDMAIIFMILGSgdvgrlvigK-----QNIDERFVTLARDIKKFWGVEMRL 338 Yarrowia lipolytica
ESW98510       291 NQLELAFLYMVIGKedigrllinK-----AQFDEQLVVFLRDIKTVFGTQFYF 338
XP_003955091   290 NQLPLAIVYMVIGKedigrlritK-----EQIDENFIHLLRDVKKIFGIEVFL 337
ybcl:Ecym_3043 288 NQLPLALVYMVIGKedigrlrisK-----DQIDERFIRLMRDIKQIFGTEAHL 335
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