4NTF


Conserved Protein Domain Family
MAPEG

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pfam01124: MAPEG 
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MAPEG family
This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism). It includes proteins such as Prostaglandin E synthase. This enzyme catalyzes the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.
Statistics
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PSSM-Id: 426065
Aligned: 165 rows
Threshold Bit Score: 34.9677
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4NTF_A  14 LA--TVTLVGVLLQAYFSLQVISARRafhvs-------ppltSg----------PP----EFERVFRAQVNCSEYFPLFL 70  house mouse
Q9I591   6 SA--ICLLGLIAWTLLLVFLLVSQRGllvlggrmavnafaadG-----------SNtpggFGQRLVRVHANCVENLPLLA 72  Pseudomonas aeruginosa
Q8F0J4   2 NPaiIALLGFIFWTLFLGLCVVSVRSfkvl--------tgsnKsnefpagikhgSe----FYWRLNRAHINCIENLPIFG 69  Leptospira interrogans
Q31QW4   4 DL--ICLLILALWTLPLNHIPAIGRAskag---------ldwAmsn-----rdrQPevpeWVGRADRAQRNHLDNLAMIA 67  Synechococcus elongat...
Q5QUG7   9 MA--YWGVLIALVILLVQWVIASGQKakqpg-------avpgKidds----lshSS----FVFRAHRTLMNSLENYPLML 71  Idiomarina loihiensis
Q3IH31   7 SA--YLAFYLYLIMLLVQWAVATFSKakqpn-------avpgKisdd----lshDS----FIFRAHRTFHNTLENSALFI 69  Pseudoalteromonas hal...
Q28W95   7 VT--LWNVVLLGVLLLLQPLVRDIVVgfk----------ytiSnf-------dnRVdegvFARRLAMVRSNQIEALALWV 67  Jannaschia sp. CCS1
Q8P7G3   9 ML--GWAMVLGLVQLLAASTSMTAQRgt------------kwNasar----dgeTKpltgVAARLDRAFRNFLETFAIFA 70  Xanthomonas campestri...
Q9A7V1   9 MI--AVAVAIGILNLLWASAAAQPQRgl------------kwNvgp-----rdeTIeltgMAGRLMRAFANFRETFPFFV 69  Caulobacter vibrioides
Q5NQE5   9 LL--GIVLLLALLQIFLTAHFKTRQYgy------------kwNvsar----deaLPplspMAGRLSRAQANLFETLPLFI 70  Zymomonas mobilis
4NTF_A  71 ATLWVAGIF-----FhEGAAALCGLFYLFARLRYFQGY---ARS---AQ---LRLTPLYASARALWLLVAMAAL 130 house mouse
Q9I591  73 GALLYAIASg----Q-SSLTDPLAPLVLGARLFQSLMH---LVStsaLFv-wLRFAGFFVQLLVLAWWLLLLAG 137 Pseudomonas aeruginosa
Q8F0J4  70 ILVLIGVFAg----VfDHRFELATQIILGARIFQTLAH---LSSg-sVFavnARFTGFMIQYGCFLYLLWHILH 135 Leptospira interrogans
Q31QW4  68 SVILIAQITgk----aDGTTAIASIVLLLARIAHSLTY---LAGl--PL---PRSLSYFVSIAALLTIVWRLFA 129 Synechococcus elongatus PCC...
Q5QUG7  72 GTVFLAFFIg----VsAFWTGIFIWIFAIARLIHMVLYyaiATEk-nPS---PRSYFFMIGLAANVALLILCGV 137 Idiomarina loihiensis
Q3IH31  70 GTVLFAFVIn----YqSPIFALCVWIYVIARLIHMVLYyaiATNk-nPS---PRSYFFLIGVLANVVMLVMVGL 135 Pseudoalteromonas haloplank...
Q28W95  68 PVILIAGIAvpdltH--PHLALIATVFLIARIAYAIMS---LAGi--PL---LRSGAWTVGFAAWACLTWIIRS 131 Jannaschia sp. CCS1
Q8P7G3  71 AAVLAVTVAg----RtNAETALGVQLYLWARVAYVPVY---ALGi--PY---LRSAIWVVSFWGIVKLVRALLG 132 Xanthomonas campestris pv. ...
Q9A7V1  70 ALVIVDYLGgr----lGDLTVYGAALYVAARAAYLPLY---AFGv--PY---VRSLVWLASMVGILMLLAALVV 131 Caulobacter vibrioides
Q5NQE5  71 AALLANLYLgh----nGYYSELSAELYVASRLIYLPLY---AFGv--PY---LRSIVWAIGIIGLLGQILLIFC 132 Zymomonas mobilis
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