1VM6,5WOL,5EER,1ARZ


Conserved Protein Domain Family
DapB_N
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pfam01113: DapB_N 
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Dihydrodipicolinate reductase, N-terminus
Dihydrodipicolinate reductase (DapB) reduces the alpha,beta-unsaturated cyclic imine, dihydro-dipicolinate. This reaction is the second committed step in the biosynthesis of L-lysine and its precursor meso-diaminopimelate, which are critical for both protein and cell wall biosynthesis. The N-terminal domain of DapB binds the dinucleotide NADPH.
Links
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Statistics
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PSSM-Id: 426056
Aligned: 98 rows
Threshold Bit Score: 71.8819
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1VM6_B  13 MKYGIVGYsGRMGQEIQKVFSE-KGHELVLKVDVNG--------------------------------------VEELds 53  Thermotoga maritima
5WOL_A   3 INVIINGInGKMGRVVKENITAqSDLELVSGTGRQddl----------------------------------akTIQTth 48  Coxiella burnetii RSA...
Q9V1P1   3 VKVGVNGY-GTIGKRVAYAITKqDDMELVGVVKTKPdfeayrakelgipvyaaneeflsrfesvgfevegtlndLLEK-- 79  Pyrococcus abyssi GE5
Q6A7P7   2 IKVAVFGAkGRMGTAVCQAVEEaEDTELVAAVDSGGd-------------------------------------RSDAsg 44  Cutibacterium acnes K...
O86836   4 LRVAVLGAkGRIGSEAVRAVEAaEDMELVAALGRgdg-----------------------------------leALAEsg 48  Streptomyces coelicol...
Q73VY3   1 MRVGVLGAkGKVGSTMVAAVQAaEDLTLSAEVDAgdp-----------------------------------lsLLTDgg 45  Mycobacterium avium s...
Q6NGP2   3 IKVGVLGAqGRVGQAIVAGVTAaYDLELVAEVDRgds-----------------------------------ldVLVQsg 47  Corynebacterium dipht...
5EER_A   2 IKVGVLGAkGRVGQTIVAAVNEsDDLELVAEIGVddd-----------------------------------lsLLVDng 46  Corynebacterium gluta...
Q8G526   2 IKVSVVGAkGRMGLHVVEAVNNaEDTQLALALDAGddl----------------------------------tqITTDn- 46  Bifidobacterium longu...
P46829   3 TRVALVGGtGKLGAIIAGVIDElDDFETVAVLGSder-----------------------------------srEIDA-- 45  Mycobacterium tubercu...

1VM6_B  54 PDVVIDFSSPEALPKTVDLCKk-yRAGLVLGTTALKEEHLQMLRE-LS---KE--VPVVQAYNF 110 Thermotoga maritima
5WOL_A  49 ADVVIDFTTPQSVFHNAEIIIq-sGARPVIGTTGLTLEQIALLDK-QC---RNkkLGAIVAPNF 107 Coxiella burnetii RSA 493
Q9V1P1  80 VDVIVDAT-PGGVGAKNKPLYekaGVKAVF-----QGGEKANVAE----------VSFVAQANY 127 Pyrococcus abyssi GE5
Q6A7P7  45 ADVIVDFTTPDAVMDNLSWAIs-hDINTVVGTTGFDDERYQVLRDqLA---DHpnIGCLVAPNF 104 Cutibacterium acnes KPA171202
O86836  49 AQVAVELTTPASVMDNLDYCLr-hGIHAVVGTTGWTDERLARLNAwLD---ASpgTGVLIAPNF 108 Streptomyces coelicolor A3(2)
Q73VY3  46 TEAVIDFTHPDVVMGNLEFLVr-nGIHAVVGTTGFTAERLAQVREwLA---DSpgTSVLVAPNF 105 Mycobacterium avium subsp. paratuberc...
Q6NGP2  48 AEVIVDFTTPDSVMDNLEFCIs-hGIHCVVGTTGFTPERLEIVKKwAE---EKgnTGVLIAPNF 107 Corynebacterium diphtheriae NCTC 13129
5EER_A  47 AEVVVDFTTPNAVMGNLEFCIn-nGISAVVGTTGFDDARLEQVRDwLE---GKdnVGVLIAPNF 106 Corynebacterium glutamicum ATCC 13032
Q8G526  47 TDVVVEFTVPSVSLNNVLTLIg-qGVDVVVGTTGWTDEKLAQVKSaIAngpKPetQKVFIAPNF 109 Bifidobacterium longum NCC2705
P46829  46 ADLVVDASTPGVSIDVVRAAIe-rGKNVLVGTSGWSTERIALVRP-LV---EAagTGAVFIPNF 104 Mycobacterium tuberculosis variant bovis
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