5A63


Conserved Protein Domain Family
Presenilin

?
pfam01080: Presenilin 
Click on image for an interactive view with Cn3D
Presenilin
Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease. It has been found that presenilin-1 binds to beta-catenin in-vivo. This family also contains SPE proteins from C.elegans.
Statistics
?
PSSM-Id: 426034
Aligned: 56 rows
Threshold Bit Score: 267.156
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
5A63_B        76 KYGAKHVIMLFVPVTLCMVVVVATIKSVSF-------YT--RKD-----GQ-LIYTPFTEDTETVGQRALHSILNAAIMI 140 human
XP_015632905  27 DSLGEDITRIVTPVSTCMLLVVLLVSLL----------SspSSPspftaAFsAAAG-----PGGGGDDITTALITAVTFV 91  Japanese rice
EFH55498      12 DSLGEELIAILTPVSICMFTVVLLVCILN--------SDpsSSSasfssIAtAAYAES--DSDSSWDKFVGALLNSVVFV 81  Arabidopsis lyr...
XP_001299078  12 EIYSKRIYKIAVPVILTLVIDVWLTRTLEEkfdntalSTsfASVv---------------SQSSGGVSTAVAIYIAIGFI 76  Trichomonas vag...
XP_001326572  12 EFYARKVAKIAVPVVLTLILDAVCIRFIERthgsaelNRnfVDTm---------------SRNDSGISVTASIWSAVGII 76  Trichomonas vag...
EPB83259      49 QFYVEQLTLLFYPLIVTFALTCWIEITLNI-------DSsqISN------PlMVYDEL--PSDSVGTRLGGSVLNAIIVV 113 Mucor circinell...
4_pfamImport   1 LNRSSQLKWTLFSVIVNMLLTLSVWIGV---------YGmeVNS-----ELsRLYFLDTASNSTTGNPVLDGAINGMFTI 66 
Q01608        11 LVRSSQLRWTLFSVIANMSLTLSIWIGV---------YNmeVNS-----ELsKTYFLDPSFEQTTGNLLLDGFINGVGTI 76  Caenorhabditis ...
EFO85358       9 FRRSSQLQWTLFSVIVNMSLTLSIWIGI---------YQmqVNS-----ELsKLYFLDDSFERTTGNTTLDGLINGFATI 74  Caenorhabditis ...
CAP30997       9 LRRSSQLQWTLFSVVVNMSLTLAIWIGI---------YHmeVNS-----ELsKMYFLDDSFNWTTGNPALDGLINGFCTI 74  Caenorhabditis ...
5A63_B       141 SVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTY-------NVAVDYITVALLIWNFG-VVGMIS 212 human
XP_015632905  92 VAVTAATFLLAFLFYLRCTPCLRAYLGFSSLSVLLLLGGHVALLLLSRL-------RLPLDAASFALLLPNAAaALALAA 164 Japanese rice
EFH55498      82 AAITVATFVLVLLFYLRCVKFLKFYMGFSAFIVLGNLGGEILVLLIDRF-------RFPIDSITFLILLFNFS-VVGVFA 153 Arabidopsis lyr...
XP_001299078  77 VAIALVTGLLLLLYWFNCVKCIYVWMVVAVSLLLSYYVYLAVGKIPSLY-------NIPIDYIAVVIFLLNGV-VVGGMS 148 Trichomonas vag...
XP_001326572  77 FMIIVVTAILLTLYYFGCMKIIFGWLILAVSLLLSMYFLVGFGTYPSIV-------NIPVDYLSLAVFLLNLV-VVGNMS 148 Trichomonas vag...
EPB83259     114 CGITLMTFMFVLCFKYRLYKFLFFWLGLSVLSILGVTASALWIEMLNVY-------NMPMDYLTMLFCTWNVA-VVGVVA 185 Mucor circinell...
4_pfamImport  67 VVLGIVSFVMLGFVLYDFQNLVKTWLIFSCLLILFGVSGQTFYDLFSQLvdqetenGRNLTLVLTILPTLVYG-LAGIVA 145
Q01608        77 LVLGCVSFIMLAFVLFDFRRIVKAWLTLSCLLILFGVSAQTLHDMFSQVfdqddnnQYYMTIVLIVVPTVVYG-FGGIYA 155 Caenorhabditis ...
EFO85358      75 LVLGCVSFVMLAFVLYDFQRVVKAWLTLSCMLILFGVSGQTLYDLFTQIldqndenQYILTVALTVIPTTIYG-VLGIYA 153 Caenorhabditis ...
CAP30997      75 LVLGCVSFVMLAFVLYDFRRIVKSWLTFSCLLILFGVSGQTIYDLFSQIfdqndenQFILTVALTVIPTVVYG-CLGIYA 153 Caenorhabditis ...
5A63_B       213 IHW-KGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSST 291 human
XP_015632905 165 LSPaSVPIALHQAALVAIAVLTAFWFTL-LPEWTTWALLVAMAVYDLAAVLLPGGPLRLLLELAIERNEEI-PALVYEAR 242 Japanese rice
EFH55498     154 VFMsKFSILITQGYLVWIGVLVAYFFTL-LPEWTTWVLLVALALYDIAAVLLPVGPLRLLVEMAISRDEDI-PALVYEAR 231 Arabidopsis lyr...
XP_001299078 149 IFW-RAPPIVTQAFMIWISVMTACVFLT-LPDWTVWILLVLLIIWDCCVVLCPNGLLHLLIKKSQERGDAI-PALVYSSA 225 Trichomonas vag...
XP_001326572 149 IFW-RAPQRITQAFLVLISILTSIVFRY-LPDWTVWILLVLLIIYDACVVLCPNGLLILLLKKSEERGDAI-PALLYSAA 225 Trichomonas vag...
EPB83259     186 IFW-KSPLWVQQVYLVLVSAATSISMLR-MPPWTTWTVLIAVAIYDLFAVLCPAGPLRLLITMAEERQENI-PALVYSAG 262 Mucor circinell...
4_pfamImport 146 FLA-NGSLLLHQCFVVSNCSLIAVFYLRAFPRHTTWFVLFIVLFWDLFAVLTPMGPLKRVQEKASDYSNNILKFLMFAAD 224
Q01608       156 FFS-NSSLILHQIFVVTNCSLISVFYLRVFPSKTTWFVLWIVLFWDLFAVLAPMGPLKKVQEKASDYSKCVLNLIMFSAN 234 Caenorhabditis ...
EFO85358     154 FFA-NGSLALHQFFVISNCSLISVFYLRAFPRYTTWFVLWMVLFWDLFAVLAPMGPLKKVQEKASDYSNNILKFLMFAAE 232 Caenorhabditis ...
CAP30997     154 FLA-NGSLLLHQFFVVSNCSLIAVFYLRAFPKHTTWFVLWTVLFWDLFAVLAPMGPLKKVQEKASDYSNNILKILMFAAE 232 Caenorhabditis ...
5A63_B       292 MVWL-----------VNMAEGDPEAQRRVSKNSKYNAESTERESQDT----VAEn-DDGGFSEe---------WEaqrds 346 human
XP_015632905 243 PVDPrhghnwrlwreRTQSGAELDANSTVEVLGEVLGTNLGASSAGNlgvsAIRsdERVGLAGdar----nlrLG----- 313 Japanese rice
EFH55498     232 PVIRndsr----lvqRRVWRERRSNDAENHANRNEVRAVRSEEve----------------------------------- 272 Arabidopsis lyr...
XP_001299078 226 AFFWkea-----ddgEEQNEEGEDHENLDNYDEEYDSASEDESTDPDssasSDDalPINPDEFvgl-----snNP----- 290 Trichomonas vag...
XP_001326572 226 AWEEadpekgnqnneEGDGNEGNQEDPAEQADNQDNNEEEEEEEEAE--------------------------------- 272 Trichomonas vag...
EPB83259     263 MASFdteddfiggyrTQESNRASKNHKKWLPFTNANKGYRPIH------------------------------------- 305 Mucor circinell...
4_pfamImport 225 DNRQsagadr---aeevnEGDGTIRRGVKQLIAMYSKQEAQDEEFAQkirqRRSawNPDSGLTeqsplvetepSP----- 296
Q01608       235 EKRLtagsnq---eetneGEESTIRRTVKQTIEYYTKREAQDDEFYQkirqRRAaiNPDSVPTehsp---lveAE----- 303 Caenorhabditis ...
EFO85358     233 DKREtagidatedssENLNDERKLRKDVKQLIELYSKKEAQDDEFLRkirqRRTaiNPDSALTetsp--vhtePS----- 305 Caenorhabditis ...
CAP30997     233 DKREsagmdmaqdsqENLNDERKLRKDVKELIQLYSKQDEKDDEFLQkirqRRNaiNPDSGSTahsp---mvtTE----- 304 Caenorhabditis ...
5A63_B       347 HLGPHRSTPESRAAVQELSSSILAGEDP-----------------------------------------------EE--- 376 human
XP_015632905 314 TSMPNLSSDSASAQVEVLPASPEISVSVpemrvpliqprpertr------------------------------------ 357 Japanese rice
EFH55498     273 -----eEHVGSSERAEISVPLIDRRPEQaensetfle------------------------------------------- 304 Arabidopsis lyr...
XP_001299078 291 EDQPPPQPKPEQQPESELAQPAGEPTKPkkkrpnqdnqhgdpenp----------------------------------- 335 Trichomonas vag...
XP_001326572 273 ------NNQPQENANGEAQNGNQNNNKKkknms----------------------------------------------- 299 Trichomonas vag...
EPB83259     306 ------NNELDENATLSIALSTLEQSRDverrnsneagq----------------------------------------- 338 Mucor circinell...
4_pfamImport 297 SVPTEHQQEEKEDKQMDSESSSESCSESasiasgdsnaddkekeeeddeyqssnietaeecdmetwqqlvneanaKQgdn 376
Q01608       304 PSPIELKEKNSTEELSDDESDTSETSSGssnlsssdssttvstsdi-----------staeecdqkewddlvsnsLPnnd 372 Caenorhabditis ...
EFO85358     306 DALIQLKSKNSDEEHTDDESDTTESSTTtsssdvttsevstaeev--------------apeewnelmeqqekqaEFdqr 371 Caenorhabditis ...
CAP30997     305 PSPIVLKEKNSDEELFDNESDTTESSSEsstssesvfsssdvsta--------------aecapeewnelihqqnEFdqn 370 Caenorhabditis ...
5A63_B       377 ------------------------------RGVKLGLGDFIFYSVLVGKASatASGDWNTTIACFVAILIGLCLTLLLLA 426 human
XP_015632905 358 ----------------deeddedgiglsssgAIKLGLGDFIFYSVLVGRAA--M-YDYMTVYACYLAIIAGLGITLLLLA 418 Japanese rice
EFH55498     305 -----------------------giglgssgAIKLGLGDFIFYSVLVGRAA--M-YDLMTVYACYLAIIAGLGITLMLLS 358 Arabidopsis lyr...
XP_001299078 336 --------------dkrkkksgsakstptseGVKLGLGDFIFYGILVTRAA--R-VGWDIAILDILAVMDGLALTLICLA 398 Trichomonas vag...
XP_001326572 300 --------------------------krdneGIKLGLGDFVFYGILVSRAA--R-IGWDITILCIFAVILGLSLTLVCLA 350 Trichomonas vag...
EPB83259     339 ---------------------dedeeedelnAIKLGLGDFIFYSVLVGKAA--K-TDSVTLCLCIIAILTGLSLTILILT 394 Mucor circinell...
4_pfamImport 377 ksnlt-----------------aadalndgETVRLGFGDFVFYSLLIGQAA--ASGCPIAVVFAAAGILFGLLVTLTVLS 437
Q01608       373 krpat-----------------aadalndgEVLRLGFGDFVFYSLLIGQAA--ASGCPFAVISAALGILFGLVVTLTVFS 433 Caenorhabditis ...
EFO85358     372 yvpvt-----------------aadalndgETVRLGFGDFVFYSLLIGQTA--TGGSALAVACSALGILFGLVATLTVFS 432 Caenorhabditis ...
CAP30997     371 datvtaadalndgvksknsgrlfseicrfpETVRLGFGDFVFYSLLIGQAA--TGGCPISVGFAAFGILFGLIATLTVLS 448 Caenorhabditis ...
5A63_B       427 IFKKALPALPISITFGLVFYFATDYLVQPFM 457 human
XP_015632905 419 FYRKALPALPVSIALGVVFYVLTRTLLETFV 449 Japanese rice
EFH55498     359 VYQKALPALPVSIMLGVVFYFLARLLLEVFV 389 Arabidopsis lyrata subsp. lyrata
XP_001299078 399 YFERPLPALPFSLALGIIFYLIGAYTFRGFS 429 Trichomonas vaginalis G3
XP_001326572 351 VWERPLPALPFSLALGIVFFIIGAMTFRQFC 381 Trichomonas vaginalis G3
EPB83259     395 LNRKALPALPISILLGCITYATAYYMTSPMI 425 Mucor circinelloides 1006PhL
4_pfamImport 438 TEESTTPALPVPVLCGTFCYFTSKFVWENLI 468
Q01608       434 TEESTTPALPLPVICGTFCYFSSMFFWEQLY 464 Caenorhabditis elegans
EFO85358     433 SGESTTPALPLPVICGTFCYFISKFVVDQVY 463 Caenorhabditis remanei
CAP30997     449 SEESTTPALPLPVICGTFCYFVSRFLVDSIQ 479 Caenorhabditis briggsae
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap