1I7X


Conserved Protein Domain Family
Cadherin_C

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pfam01049: Cadherin_C 
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Cadherin cytoplasmic region
Cadherins are vital in cell-cell adhesion during tissue differentiation. Cadherins are linked to the cytoskeleton by catenins. Catenins bind to the cytoplasmic tail of the cadherin. Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region of the cadherin. This region induces clustering and also binds to the protein p120ctn.
Statistics
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PSSM-Id: 426014
Aligned: 98 rows
Threshold Bit Score: 104.95
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1I7X_B          2 RRTVVKEPLL---PPDDDTRDNVYYYDEEGGGEEDQD-FDLSQLHRGLD------------------------------- 46   house mouse
9_pfamImport    1 RRSEKEATLF-----EELPRENIFIYNEEGGGEEDRE-FDWTLLSRGP-------------------------------- 42  
6_pfamImport    1 RGVYHIPAEH---ESWEDIRENILNYNEEGGGEQDQVcKQSALLLFHPDr------------------------------ 47  
XP_015784984 2516 RRTDQKFGHG---DMDDDVRENIINYDDEGGGEDDMNaYDITPLRIPIDphglkqdpkgtl------------lksgrqr 2580 two-spotted s...
EDW39763     1514 SRKRKTTKKKkrsGPEKDVRETVISYEDEGGGEDDMTaFDITPLQIPISaqgggsmppdiaac--------kmpiiypvm 1585 Drosophila pe...
EFX70325     2791 RRRESTVRYA---GPDDDVRENIINYEDEGGGEDDMTaYDITPLQIPIGghglglgydtmkg----------gkipyhsp 2857 common water ...
XP_001866918   58 RRRESHIKYP---GPDDDVRENIINYDDEGGGEDDMTaYDITPLQIPIGpmpeltqckmp--------------plmypv 120  southern hous...
Q7Q1L9       1402 RRSANFNKKP---ATKDDIRENIINYCDEGGGENDMTaFDMKTLKIPIG------------------------------- 1447 Anopheles gam...
OWR45146     1615 RRREAHIKYP---GPDDDVRENIINYDDEGGGEDDMTaFDITPLQIPIGgplpdhvptklpyplmgvglgvgpmgvsvap 1691 Danaus plexip...
XP_016661061 1718 RRRESHIKYP---GPDDDVRENIINYDDEGGGEDDMTaFDITPLQIPIGgsmnnmhpqky--------------kypamp 1780 pea aphid
1I7X_B         47 -----ARPEVTRNDVAP-TLM-S----VpqyRPRPANPDEIGNFIDENLKAADSDPTAPPYDSLLVFDYEGSGSEAASLS 115  house mouse
9_pfamImport   43 -------GSCAEVTCTQgLPPdRs--hPgc-qHLR-AHEDISRFLKDKLQAAGGGVPAPPHRSPLVLDRQGAGSQASSL- 110 
6_pfamImport   48 ----cAPACPSRPPAPQpRSSnplrvprrsaPSGSRSHVDFKSYVARIIWEADNDSEAFPPDAFH-------------IC 110 
XP_015784984 2581 qyppgAHL-------------------------------DIGEFIQENLNKVDSDPNAPPFDDLRNYAYEGCGSNAGSLS 2629 two-spotted s...
EDW39763     1586 tllppGQE------------------------------LNVAYLMEERKQRIDKDPNAPPFDDLRNFTFEGSGSIAESLS 1635 Drosophila pe...
EFX70325     2858 apmmmSGE------------------------------PNVGVFIDDHKRRADTDLNAPPYDDLRNYAYEGGGSTAGSLS 2907 common water ...
XP_001866918  121 mtmgpGHE------------------------------PNVGMFIEEHKKRADSDPNAPPFDDLRNYAYEGGGSTAGSLS 170  southern hous...
Q7Q1L9       1448 ------PLPELVQHKAPpVRPdIa--vVs--dQVV---GKVDVFLDDRKRRVDIDPASGPFDDLRNYAYEGCGSTSGSLS 1514 Anopheles gam...
OWR45146     1692 avvplPGE------------------------------TNVGMFIEDHKRRADSDPNAPPFDDLRNYAYEGGGSTAGSLS 1741 Danaus plexip...
XP_016661061 1781 vgvgvGVE------------------------------PNVGIFIEDHKKRADGDPNAPPFDDLRNYAYEGGGSTAGSLS 1830 pea aphid
1I7X_B        116 SLNSSES-DQDQDYDYLNEWGNRFKKLADMYG 146  house mouse
9_pfamImport  111 ----FTDpDEEQNFQRLDGWGPGSCNRVELCA 138 
6_pfamImport  111 SLGSAEDdERGFAYDRLLRWGPKFQTLSDMYD 142 
XP_015784984 2630 SLASGNE-DNEQDFDYLNGWGPRFQNLARMYE 2660 two-spotted spider mite
EDW39763     1636 SLASGTD-DENQDFNYLQNWGPRFNALAAMYV 1666 Drosophila persimilis
EFX70325     2908 SLASE---DDEQDFDHLNGWGTRFQKLADMYG 2936 common water flea
XP_001866918  171 SLQSGTD-DEVQEFDYLDAWGPRFDKLANMYG 201  southern house mosquito
Q7Q1L9       1515 SLQSGTD-DEPHEYSFLTTWGPRFDKLVNIYE 1545 Anopheles gambiae str. PEST
OWR45146     1742 SLASGTD-DEVHDYDYLGAWGPRFDKLADLYG 1772 Danaus plexippus plexippus
XP_016661061 1831 SLNTGTE-DDHQDYEYLVSWGSHFDKLADMYS 1861 pea aphid
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