1PF5,3QUW,1JD1,1QD9,1QU9,2UYN


Conserved Protein Domain Family
Ribonuc_L-PSP

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pfam01042: Ribonuc_L-PSP 
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Endoribonuclease L-PSP
Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella.
Statistics
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PSSM-Id: 426010
Aligned: 25 rows
Threshold Bit Score: 92.3611
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1PF5_A        13 HSlyaEHRYSA-AIR--SGDLLFVSGQVGSRE----DGTP---EPDFQQQVRLAFDNLHATLAAAGCTFDD------IID 76  Escherichia coli
P0AFQ5        12 SAp--LAPFVP-GTL--ADGVVYVSGTLAFDQ----HNNVl-fADDPKAQTRHVLETIRKVIETAGGTMAD------VTF 75  Escherichia col...
Q9ZBJ6        13 VAp--AAQYTHvVLG--TGRFVAVSGQLALD-----EDGKvvgEGDPAAQARQVFENLRRCLASAGAAFDD------VVK 77  Streptomyces co...
O86529        13 DRl----AYNRaVLVeqPRRWLVVAGHEARD-----DEGGiaaVDDVRGQLRLTFRRLAETLDKAGFALSD------LVQ 77  Streptomyces co...
Q8YYS9        60 lydatRNGYSHiAVTpaRTRTVYISGQFGSDL-----YGRl-vSTEFEPQLVRAFQNLRFALDAVGAKPSD------VVK 127 Nostoc sp. PCC ...
Q4CQG3        82 AAp--ATNYVS-YVC--SGMQLHVSGQLPKNDvggcMTGQlgaSLTVTEGQAAARACALQVVSQMQAALGDldrvkrVVK 156 Trypanosoma cruzi
Q55925        88 NEl----HYSQ-AVK--IGDRVETSGQGGWD-------DNlqiPELLADEIAQAFQNIERTLAAAGAGWEH------VVH 147 Synechocystis s...
WP_003419733  18 AAp--LAAYVP-AVR--TGNLVYTAGQLPLEAgklvRTGKlgaDVNPEEGKTLARICALNALAAVD-SLVDldavtrVVK 91  Mycobacterium t...
P0AEB7         4 VRidaEARWSD-VVI--HNNTLYYTG-VPENl-----------DADAFEQTANTLAQIDAVLEKQGSNKSS------ILD 62  Escherichia col...
O30825         3 TRidvTNRFSEvAIY---NGIAYFAGQVPTDE-----------SKDAYQQTQQVLSEIDKYLAKSNTDKSR------ILM 62  [Haemophilus] d...
1PF5_A        77 VTSFHTDPENqFEDIMTVKNEIFSAPp--------yPNWTAVGVTWLA--GFDFEIKVIAR 127 Escherichia coli
P0AFQ5        76 NSIFITDWKN-YAAINEIYAEFFPGDk---------PARFCIQCGLVKp-DALVEIATIAH 125 Escherichia coli K-12
Q9ZBJ6        78 LTFFVTDMAN-MGAIRAARAEHIPDDr--------lPAASAVQVAALVrpEFLMEIEAFAV 129 Streptomyces coelicolor
O86529        78 IRIFTVDIEAvTAHYDAVLDELAAADc--------rPASLLAEVRALSdpRMLVEIEGLAA 130 Streptomyces coelicolor
Q8YYS9       128 TTVLIVDHTE---DKLIPLGREIQNLwpf-----rpPANTLIPVPRLAlnGMLFEIDAYAV 180 Nostoc sp. PCC 7120
Q4CQG3       157 LNVFVNSSPS-FTEQSYVANGASDLIlsvfgeeagrHARCAVGVAQLPf-GAAVEVDALVE 215 Trypanosoma cruzi
Q55925       148 VNSYHVGGLP--PEVNDVMVRLYRHYmpn-----haPIWTQVGVAALGlpTMRIEIRVTAI 201 Synechocystis sp. PCC 6803
WP_003419733  92 VVGFVASAPG-FHGQPSVINGASDLLaevfg-dsgaHARSAVGVSELPl-DAPVEVELIVE 149 Mycobacterium tuberculosis complex
P0AEB7        63 ATIFLADKND-FAAMNKAWDAWVVAGh--------aPVRCTVQAGLMNp-KYKVEIKIVAA 113 Escherichia coli K-12
O30825        63 ATVYLANMAD-YTEMNRAWDEWVAPNn--------aPPRAAIEARLANp-NWKVEIVITAA 113 [Haemophilus] ducreyi 35000HP
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