2B9S


Conserved Protein Domain Family
Topoisom_I

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pfam01028: Topoisom_I 
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Eukaryotic DNA topoisomerase I, catalytic core
Topoisomerase I promotes the relaxation of DNA superhelical tension by introducing a transient single-stranded break in duplex DNA and are vital for the processes of replication, transcription, and recombination.
Statistics
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PSSM-Id: 460030
Aligned: 94 rows
Threshold Bit Score: 166.153
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2B9S_A               234 SSSVKG---------QSDMVKFEKARKLKDKVDDIRASYMEDFKSN--DLHVAQRAVAMYFIDRLALRVGNEKGEDEADT 302 Leishma...
goetting:Ngar_c04450 221 SAALRQ---------ENDRAKYDKAKKLAEQESRVHREVIRRMMKG-----GDKTATVAYLILKLAMRVGDEKDPDEADT 286
BAJ47816             213 TADIKQ---------KRDKSKYDKAEMLESHIDRVREKIFKGLRSK--EPKMREIALACYLIDRLAMRVGDEKDPDEADT 281
ABK76827             211 TAGLKQ---------ERDRSKYEKAVALSKKIGEIEAKIVKDMKSK--DPKISKIATACYLIYRTAMRVGDEKDKDEADT 279
jgi:Nmar_1322        214 SSDLKQ---------GRDKEKYEKAVKLEKEIEKIKKAMVKDMK----DSKKNNVATACYLIYKTAMRVGDEKDEDEADT 280
XP_004347638         391 SAKLIQ---------EATAAKFDQVRKLGEHISEIREQVFKCMRLAkePTVQAQTALGVYLLDQLALRPGTSKI-DTDSS 460
jgi:Dfer_3186        105 AAGRKQyryhpywnlVRNQAKYYKLLMFSEALPVLREQVEHDLRKRd-FDLSKVIALVIKLMDKTCIRVGNQRYKVRHGS 183
jgilanl:CHU2291       83 AKNRKQyryhpawsnLRDQTKYCRLRDFSHALPEIRARIKEDLCQRg-FPKNKVLAAVVSIMESTSIRVGNSMYEKLYGS 161
jgi:Niako_5849        94 LRNRKQyryhplwsvMRNETKFHRMAEFGKALPALRQRLESDLSQRs-LTASKVIATVVSLMAQTYIRVGSGEYEKQNGS 172
WP_014785394         103 ARGRKQsryhphwreVRDETKYERMAHFAKSLPGIRKRVAEDMARGg-LPREKVLATVVRLMEETHIRVGNEEYARTNKS 181 Terrigl...
2B9S_A               303 VGCCSLRVEHIQLMP---D-NIVRFDFLGKDSIRYQNDVAVLP----EVYALLQRFTRR-KSPGMDIFD---------QL 364 Leishma...
goetting:Ngar_c04450 287 VGASTLRVEHIKFPQaggGrQMIEFNFLGKDSVPWQKTLEVNSddtkALYENLKKFMQG-KKPSDPIFD---------GI 356
BAJ47816             282 VGATTLRVEHVKLLE-----DRIEFDFLGKDSVRWQKSIDLRKep-pEVRQVFEELLEG-KKEGDQIFQ---------NI 345
ABK76827             280 VGATTLRKEHIRISD-----GVIEFDFLGKDSIRWNEKLKVTGdd-eQFSRNLQGLVKS-IKPKDEIFK---------DI 343
jgi:Nmar_1322        281 VGATTLRKEHIKITS-----DTIEFDFLGKDSVRWQETLKVVGdd-kQFQENLKKLIEK-KKPSEEIFH---------DI 344
XP_004347638         461 YGLFTLLPKHVKLVE---P-RTISFDFPGKDMVQYTNSVEVDP----SAFKVFKMMMAAaKDPKTPVFD---------SS 523
jgi:Dfer_3186        184 SGITTLDARCAT-VT---G-SRIRFMFKGKKGIQQ----DITL----RDKQLARLVKQCkEMPGKRLFQyinenggkcAL 250
jgilanl:CHU2291      162 YGLSTMKDRHVK-IQ---G-QEVQFSFKGKKGVYH----KISL----KSKKLAHIVSQCkDIPGKELFQyfdekgnnhSI 228
jgi:Niako_5849       173 HGLTTLKDKHVV-IA---G-DTIKFSFKGKKGVSH----NITL----KSKRLARIVKNCrEIPGAELFQyyddeghkhPI 239
WP_014785394         182 YGLTTMRTKHVD-VH---G-ATVRFSFQGKSRVHH----TIDL----ADKRIARIVKQCsDLPGHDLFQyvdedgnphSI 248 Terrigl...
2B9S_A               365 NPTQLNDHLKSFM-DGLSAKVFRTYNASITLDRWF-KEkpvDPKWSTADKLAYFNKANTEVAILCNHQKS 432 Leishmania donovani
goetting:Ngar_c04450 357 NSRKVNAFLQEIM-PGLTAKVFRTCIATRVVQQEL-SKakvDKNSSEAQKIYAARKANLEAAIKCNHKKG 424
BAJ47816             346 NSRHVNRFLGKIV-KGLTAKVFRTYIATKIVKDFL-AAiprEKVTSQERFIYYAKLANLKAAEALNHKRA 413
ABK76827             344 RSSDVNRYYSGIV-KGVTAKVFRTYLASKKVSEYL-RKndkIRSKSAFFKLYHAKSANLEAAIMCNHKRT 411
jgi:Nmar_1322        345 TSRDVNKYLSGIV-KGVTAKVFRTYQATTVVKNYL-VNhdnIKGKSDNEKLYHAKLANLEAAIMCNHKRT 412
XP_004347638         524 VGTRVDTFVKSFD-KNFSARSFRTYSASSLFERSLpDC----RKVSEVHKKAAFDRANVAVARLCNHQRI 588
jgi:Dfer_3186        251 NAQQVNDYIRRHTgASFSAKDFRTWMGTVTAFEYL-SHq--eKAASQRQLTRTLNSCLDAVAAHLGNTRA 317
jgilanl:CHU2291      229 DSGDVNDYIREISgGDFTSKDFRTWTGTVKCLQAF-SNl--gHGENNTQVKRLMNEAMDIVAHQLGNTRS 295
jgi:Niako_5849       240 DSGMINSYIKETTgSDFTSKDFRTWAGSINLLRSL-QAm--gEAVTQTEQKKNIVAALDEVSLKLGNTRT 306
WP_014785394         249 DSQAVNDYLREVTgEHFTAKDFRTWAGSVLCCDLL-SEf--ePASSITEAKKNVVQAIAQVAAKLGNTPS 315 Terriglobus roseus
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