4RL4


Conserved Protein Domain Family
GTP_cyclohydro2

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pfam00925: GTP_cyclohydro2 
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GTP cyclohydrolase II
GTP cyclohydrolase II catalyzes the first committed step in the biosynthesis of riboflavin.
Statistics
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PSSM-Id: 460000
Aligned: 586 rows
Threshold Bit Score: 69.7928
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4RL4_B            69 VRLHSECLTGDALGSQKCDCGGALQMALERIskEG-GLVIYLR-QEGRGIGLF--N-----KVNAYALQD-KgydtiQ-- 136 Helicobacte...
jgi:Xaut_4136    326 VRLHRADPIADAFGG-----GKTIQRALERIeaEGrGVLVYL--RDG-TAGVPavAmghggEK----------------- 380
jgi:AciPR4_1968  257 VRVHTHNLADDVFNSTPSDHRLTIDDALRAIaeAGcGALLYLHdTGPG-FHLD--R-----NVTPPRIHLhA-----Agi 323
jgi:Terro_2321   258 VRVHTHCLAGGIFCHDGCECRQSVENAMRLIaeHGrGALVYLHnGSRG-FGID--R-----TTTPPRMVMhR-----Daa 324
jgi:AciPR4_2614  254 VRVHRQCLRGDVFNSTSCNCRRFVDQSLYAIaqEGrGALVYLDnLGQGCHTEE--AadpagVL----------------- 314
jgi:AciX9_1521   257 VRVHTHSLAEDVFGLVGTDNREVIDGSLRMIgeAGrGALIYLHnGTRG-FGVD--R-----TVEPHRIVFqK-----Dqr 323
jgi:AciX8_2387   260 VRVHTHCLSGNIFAASLCDCRAVVEGSLRAIaeAGrGALVYLHhTQRG-FGID--R-----TVQPGRLSFhR-----Eeg 326
WP_012680814     261 VRVHSHCLAGDVFGSPVCDCHSILQESLRIIaqAGrGALLYLHnTSRG-FDID--R-----RAEVPRILFhT-----Err 327 Acidobacter...
Q027B5           251 VRMHSRCVFGDVFRSSQCECGQLVQNSLRAIakEGqGVLVYLHeTGPG-FRVDsgQ-----LVSHGRDFMh--------- 315 Candidatus ...
jgi:Acid345_3140 256 VRMHAHCLVGDVFGATQCDCSKTIERALEMIarEGrGALIYLHqTSKG-YSVE--K-----LGDKLTIQFhH-----Dlr 322
4RL4_B           137 ------ANEMIGFKDDERDYSVAGEILEYYRIKKMRLLTNNPKKIAALEKy------AEVTR 186 Helicobacter pylori 26695
jgi:Xaut_4136    381 ------SSSEIERDRHWREVGLGAQILRDLGIVSIRLLASKSRTYVGLAGfgieivdTEPld 436
jgi:AciPR4_1968  324 ----ttAHTDDSSQRTLRDSGVGAQILSDLGLKRIRLLTNRPTHVPALQGfgi--eiVDQIS 379
jgi:Terro_2321   325 ----mrASSKDQSQ-TLRHTGIGGQILSDLGIHRIRLLVSRPTHVPALQGfgi--eiVEQVA 379
jgi:AciPR4_2614  315 ------HSEGYGSEGTLRHVGIGGQILSDLGIQKIRLLTNTPTHIPALAGfgl--eiVEFVP 368
jgi:AciX9_1521   324 ----grERGDDHTQRTLRQVGLGGQILSDLGIRKIKLLTNTPTHVPALQGfgi--eiVEQVP 379
jgi:AciX8_2387   327 r---snEGPGDKEHRILRQVGLGGQILSDLGIKKIKLLSNHRTHVPALQGfgi--eiVDQVS 383
WP_012680814     328 mreshpEGNSDRHQRILRQVGLGGQILADLGIRKIRLLSNTPTHVPALQGfdv--eiVEQLS 387 Acidobacterium capsulatum
Q027B5           316 ------LKGEDGQRQLQHEHGLGAQILSDLGLHTIRLLTNHPRKIVALEGfgi--evEAQIP 369 Candidatus Solibacter usitatu...
jgi:Acid345_3140 323 -----lPTLPEHQRKTQREVGIGAQILSDLGLTRIRLITNRPRRVAGLEGfgi--hiVEQVP 377
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