4A6E


Conserved Protein Domain Family
Methyltransf_2

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pfam00891: Methyltransf_2 
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O-methyltransferase domain
This family includes a range of O-methyltransferases. These enzymes utilize S-adenosyl methionine.
Statistics
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PSSM-Id: 395719
Aligned: 8 rows
Threshold Bit Score: 253.482
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4A6E_A       117 WGHLADAVREGRNQ--------YLETFGVPaeeLFTAIYRSEGERLQFMQALQEVWSVNGRSVLTAFD--LSVFPLMCDL 186 human
P10950       117 WRHLAEAVREGRNQ--------YLKAFGIPseeLFSAIYRSEDERLQFMQGLQDVWRLEGATVLAAFD--LSPFPLICDL 186 cattle
B3GSH5       116 WAHLAAGVREGRNQ--------YSRAVGISaedPFSAIYRSEPERLLFMRGLQETWSLCGGRVLTAFD--LSRFRVICDL 185 Norway rat
Q92056       118 WHYLTDAVREGRNQ--------YERAFGISskdLFGARYRSEEEMLKFLAGQNSIWSICGRDVLTAFD--LSPFTQIYDL 187 chicken
P54906       141 YRDLADPVAFLKGEtepelarfWPYVFGAG-------GATDPEVTAKYSRLMTESQGLVAEDALRLVD--LMGVRRLMDV 211 Cereibacter sph...
P47917       136 FSELGAWFQHELPDpc-----iFKHTHGRG---IWELTKDDATFDALVNDGLASDSQLIVDVAIKQSAevFQGISSLVDV 207 Zea mays
XP_002317838 140 WYYLKDAILDGGi--------pFNKAYGMT---AFEYHGTDPRFNKVFNKGMSDHSTITMKKLLETYKg-FEGLTSLVDV 207
CDM87233     133 WYYLKDAVLDGGi--------pFNKAYGMS---AFEYHGTDPRFNRVFNEGMKNHSIIITKKLLESYKg-FEGLGTLVDV 200
4A6E_A       187 GGGAGALAKECMSLYPGCKITVFDIPEVVWTAKQHF-SFQEEEQIDFQEGDFFKDPLP-EADLYILARVLHDWADGKCSH 264 human
P10950       187 GGGSGALAKACVSLYPGCRAIVFDIPGVVQIAKRHF-SASEDERISFHEGDFFKDALP-EADLYILARVLHDWTDAKCSH 264 cattle
B3GSH5       186 GGGSGALAQEAARLYPGSSVCVFDLPDVIAAARTHFlSPGARPSVRFVAGDFFRSRLP-RADLFILARVLHDWADGACVE 264 Norway rat
Q92056       188 GGGGGALAQECVFLYPNCTVTIYDLPKVVQVAKERL-VPPEERRIAFHEGDFFKDSIP-EADLYILSKILHDWDDKKCRQ 265 chicken
P54906       212 GGGTGAFLAAVGRAYPLMELMLFDLPVVAEAAPQRLtEAGLAGRFTVHGGSFRDDPLPlGADAISLVRVLFDHSDETVKL 291 Cereibacter sph...
P47917       208 GGGIGAAAQAISKAFPHVKCSVLDLAHVVAKAPTH-------TDVQFIAGDMF-ESIP-PADAVLLKSVLHDWDHDDCVK 278 Zea mays
XP_002317838 208 GGGTGAVVNTIVSKYPSIKGINFDLPHVIEDAPSY-------PGVEHVGGDMF-VSVP-KADAVFMKWICHDWSDAHCLK 278
CDM87233     201 GGGVGATVAAITAHYPTIKGINFDLPHVISEAPPF-------PGVTHVGGDMF-QKVP-SGDAILMKWILHDWSDEHCAT 271
4A6E_A       265 LLERIYHTCK---PGGGILVIESL-LDEDRRGPLLTQLY---SLNMLVQ-TEGQERTPTHYHMLLSSAGFR 327 human
P10950       265 LLQRVYRACR---TGGGILVIESL-LDTDGRGPLTTLLY---SLNMLVQ-TEGRERTPAEYRALLGPAGFR 327 cattle
B3GSH5       265 LLGRLHRACR---PGGALLLVEAV-LAKGGAGPLRSLLL---SLNMMLQ-AEGWERQASDYRNLATRAGFP 327 Norway rat
Q92056       266 LLAEVYKACR---PGGGVLLVESL-LSEDRSGPVETQLY---SLNMLVQ-TEGKERTAVEYSELLGAAGFR 328 chicken
P54906       292 LLHRVREALP---AGGRVIVAEAMsGGARPHRETDTYM----AFYTAAM-RTGRVRSAAEIAELLTGQGFS 354 Cereibacter sphaeroides ...
P47917       279 ILKNCKKAIPpreAGGKVIIINMV-VGAGPSDMKHKEMQaifDVYIMFI--NGMERDEQEWSKIFSEAGYS 346 Zea mays
XP_002317838 279 FLKNCYDALP---ENGKVILVECI-LPVAPDTSLATKGVvhiDVIMLAHnPGGKERTEKEFEGLAKGAGFQ 345
CDM87233     272 LLKNCYDALP---AHGKVVLVECI-LPVNPEATPKAQGVfhvDMIMLAHnPGGRERYEREFEALAKGAGFA 338
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