2HYE,5N4W,6V9I


Conserved Protein Domain Family
Cullin

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pfam00888: Cullin 
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Cullin family
Statistics
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PSSM-Id: 425932
Aligned: 347 rows
Threshold Bit Score: 141.541
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2HYE_C         63 WRKLHEAVRAVQs---S-TSIRYN-------LE-ELY------QAVENLCS---HKVSPMLYKqLRQACEDHVQaqilpf 121 human
XP_001313683   70 MAYLKEGIHLLF----DdKIQNAN-------FA-KLF------TNVEYICR---NKTPEYLYKsISEDMQEAALnf---i 125 Trichomonas va...
A0BYN1         18 WKYLDDACYLIA----EhQTKQLS-------FA-ELY------QHAYKLIL---NKFGDFAYSqLQISIHNVVDkli-sp 75  Paramecium tet...
Q236H3         55 WDVIEQAIQMIY----EkKTHTLS-------YQ-ELY------HHAYILAF---YGHGDQAYSrLKSLLEKYSLkmlntl 113 Tetrahymena th...
12_pfamImport   1 LDRVRRNLKTGE----AiKISNEE-------YC-KLQseirntD-QFNLIG-----------NwHKEQILNYVNs----- 51 
EAY01000       15 LEEISKSITSIL----ThKHSSLS-------LS-YLY------NCMNNLVN---NSCTNKLRDtLQNHLDKQFSkqynsl 73  Trichomonas va...
A0CFE8         15 INNLRDHIEKVLk--gEkKVYNTK-------ETmTFY------TEIFNYIVq-gEQQGQKMYDlFKGYNEDFLKesekia 78  Paramecium tet...
Q9XZJ3         16 WKNIADQVYKILt-----GSQNVS-------AM-FLY------EDVYKLCIaqpQPYCEPLYEnIKKFFEQHVDqi---l 73  Dictyostelium ...
CBJ31794       15 WVLLESSLITILqdlgQ-GFPNDL-------WI-SLY------TGVYKLCTkpmDPQHSKLYArLKETLELYVAgvl-kg 78  Ectocarpus sil...
Q24DT3         27 kpnqnyfeknwleieqflKSIYESedincycFQ-HFY------DMISSICD---NEFDELLYKkLEEFYRLKFNvil-nd 95  Tetrahymena th...
2HYE_C        122 rEdsLds-vL----F-L------------KKINTCWQDHCRQMIMI-RSIFLFLDR-----------------TYvlqnS 165 human
XP_001313683  126 nSi-Se---E----FdI------------TLISQKISLFEKCLDYF-LRTFLYLDR-----------------SY----- 162 Trichomonas va...
A0BYN1         76 lNisNd--dQ----L-L------------YDFVQAFEEVQHFSKLL-AGILLYMEK-----------------SYilqk- 117 Paramecium tet...
Q236H3        114 gYydSe--eQ----I-L------------VKMVAVWQDYKQMINIL-KGIFLYLDN-----------------NYvttk- 155 Tetrahymena th...
12_pfamImport  52 -I-------K----IdLdsktnvpeeeyiKLISKHYYDFQILVMWI-QKFLMSHET-----------------FYf---K 98 
EAY01000       74 sKtaLv--nP----L-V------------IKFSKHCSYFASFLKIL-PKLYSRYDEsla-----------ensEY----- 117 Trichomonas va...
A0CFE8         79 rQslKsd-kN----F-I------------EEILYQHEIYEIHTRIL-QSYFTYLDRsfvev-------lnntsQY----- 127 Paramecium tet...
Q9XZJ3         74 lIi-Ld---Tks--dtI------------SEYLKQWKLFFSGCELCnKVIFRYLNLnwinkkildkkfghppdVY----- 130 Dictyostelium ...
CBJ31794       79 lLafDnataHsyteL-L------------VRYRTSFHNYSVGMHYG-SDWFKYLDRhwintnhcetgvspkegVY----- 139 Ectocarpus sil...
Q24DT3         96 iAlqPe---D----F-I------------NKIEKEWIKINRCLIIL-SEIFKQFEG-----------------SY----- 132 Tetrahymena th...
2HYE_C        166 ---T----LPSIWDM-----GLELFRTHII-S------DKmvqSK---TIDGILLLIERERSG--------EaVD----R 211 human
XP_001313683  163 -----------IFPLri--dGFTSLSEIVYsyirngmsKEl-aDL---ISDQILITISKYR------------------- 206 Trichomonas va...
A0BYN1        118 -------slkTIKTI-----CNESFKIKCFeKd-----QNl-aNK---LLNCFLSQIRNDR-------------NsqfiE 163 Paramecium tet...
Q236H3        156 -------nlqPVLVL-----GYEVFQQILFiQk-----SEi-ySK---VLEIILTMIDKQRLGen-------------iE 201 Tetrahymena th...
12_pfamImport  99 aqlQttcfKK----------SFEFFRDEYF--------LGl-kDR---LIEKVFKFVQKAR-------------QnvdvP 143
EAY01000      118 ----------RTEKI-----LFTKFKEKVLnQ------TKv-vDL---IIKSMIDVIEDAR------------TNrivsG 160 Trichomonas va...
A0CFE8        128 ----------PNLKQqakkqFYEQFYNKLFfS----------------IKEEFKAKLKLDR------------------- 162 Paramecium tet...
Q9XZJ3        131 ----------EIQIL-----GLMIWKERLF-F-------Ki-kDR---VLKCVEILIQKDRDGelv---qhQ-------- 172 Dictyostelium ...
CBJ31794      140 ----------FVREM-----SLMVWKERVF-E-------Al-kER---LRHNTMKVINAARernlsnlddnD-------- 184 Ectocarpus sil...
Q24DT3        133 -----------LYKT-----KTPSFDNFILkilsdqfnQEf-nSLldaIITSLLDTFRNIR-------------DqnpyN 182 Tetrahymena th...
2HYE_C        212 -SLLRSLLGML----S--DLq---------------------------VYK----------DSFELKFLEETNCLYAAEG 247 human
XP_001313683  207 ---LHEEIKLS-------ELktglnf-----------------akstkFYN----------DHLEPTLLIQTKDYFED-I 248 Trichomonas va...
A0BYN1        164 hFKLKKALQIL----I--DLnqeqqiknkey------nytidyrinddFYK----------HFLERKLIQDSRSYFKEES 221 Paramecium tet...
Q236H3        202 gQLIQKIIQMS----V--DLgmkaniqkcnqys---rqiqyeyipeltIYE----------KYFEKGYLDCSEKYFSEES 262 Tetrahymena th...
12_pfamImport 144 kEELKRVVQIY----DdqDFgndirieedrqshklrvisdsssnkqsnNYV----------DLFEKPYLVEIEKHFQK-Q 208
EAY01000      161 tANLRQIIELF----Y--------------------------------EYKnsncd-rsifENFMASLKESTKKKYEN-- 201 Trichomonas va...
A0CFE8        163 -ILLDKESQLLlqrvY--KI----------------------------IYGmktfqdignnQLIQKEIKEDSKTYYQQQY 211 Paramecium tet...
Q9XZJ3        173 --FISQFMESL----I--KLdsvd--------------------kdrtLYL----------IEYEASYLENTRQFYTRES 214 Dictyostelium ...
CBJ31794      185 --AVRSLLKTY----E--TLgfekr-------------------drshLFQ----------TELEDFLVTDTGRYYSRRG 227 Ectocarpus sil...
Q24DT3        183 hEQLKHLMGMI----I--KIg---------------------------SYE----------NQFKSHFFEQSNKYYLDLQ 219 Tetrahymena th...
2HYE_C        248 QRLMQE------ReVp-EYLNHVSKRL---EEEGDRVI--------TY-L-DH----STQ-------KP-LIACVEKQLL 295 human
XP_001313683  249 SSHLSLkdlinwNySs----KEIETQLqecGLEKS-----------TY-LsIDsmqnEIV----------LKKAGQRVLF 302 Trichomonas va...
A0BYN1        222 QSNLN-------KmTieEYILFVEKRY---LDEVDRVQ--------HY-I-PK----ISH-------QK-VLDCFIKIYI 269 Paramecium tet...
Q236H3        263 QRLIL-------QlSpkDYIIAVERRF---LEEKKRVH--------SY-F-YQ----TSK-------NK-IQSLFFQKYI 310 Tetrahymena th...
12_pfamImport 209 ASLWT-------DkTtpEYVQEALIAL---NKEEQLCQ--------DY---YP----RSM-------NP-INQTINGIII 255
EAY01000      202 -EYNS-------SeNfvEFLKRIKELL---DFEEN------------LlL-------KAIfkdeedvNE-ILMIAHESAI 250 Trichomonas va...
A0CFE8        212 SNFQQq-----------SFLDQIKSLVqfkQEELGRIRlifgceqsE--L-----------------QKeLIDLFNNYII 261 Paramecium tet...
Q9XZJ3        215 VAFIAS------SgIs-SYMKKAETRI---DEEEQRSQ--------KY-L-NS----SSH-------DK-MRRLLHSILI 262 Dictyostelium ...
CBJ31794      228 SDLLQH------MsVp-RYLQEVERYL---QEEASRCE--------SF-V-GS----YSA-------RR-ILVAAQEALI 275 Ectocarpus sil...
Q24DT3        220 QKHRA-------NfDlrVYLQEIEHRL---QQETGLIE--------AY-L-SK----ATG-------KI-LIDLIQKHLI 267 Tetrahymena th...
2HYE_C        296 GEHL---------------TAILQK--G---LDHLLd--------------EnrVPDLAQMYQLFSRV----RgG----- 332 human
XP_001313683  303 SQEF---------------YDMIDQ------FD---------------------KEELKRVVSTFDKEe----------- 329 Trichomonas va...
A0BYN1        270 TSNA-----------------------------QHIsqglyd----fieneK--TAIIIIIFQLFVKSeefdL------- 307 Paramecium tet...
Q236H3        311 NDFA---------------KAIVDN--QengLFNWLdn------------dE--VVIIKKSHTLFQNTkesyTi------ 353 Tetrahymena th...
12_pfamImport 256 KDQT---------------QYLLEHst---gIENMLkn------------gK--DNEMKDLYKLLCRVkeslAq------ 297
EAY01000      251 FKNTetfanqkdfqvppiySALQDK--------NLLrwlirdsylrfhqknhimCEFIPKICEFMTKD------------ 310 Trichomonas va...
A0CFE8        262 NSYA---------------SDLNSD--NndtLKNIIiq------------dY--YEQFGQLVKFFDHFksntHi------ 304 Paramecium tet...
Q9XZJ3        263 EKHK---------------ELLQSE------CINYLk--------------DekLDEIYNMYKLLSRIe----gG----- 298 Dictyostelium ...
CBJ31794      276 KAHS---------------SRLVEE------ARGMLsa------------sPekRVDLRRLFTLISYLe----dGetrgg 318 Ectocarpus sil...
Q24DT3        268 AENL---------------ETIFSNgfD-----DLLnq------------rD--YQNLQRLFHNMRNIdkldF------- 306 Tetrahymena th...
2HYE_C        333 --------QQA-LLQHWSEYIKTFG-TAIVINp-----------------------------EKDKDMVQDLLDFKDKVD 373 human
XP_001313683  330 --------LRKlLLKSVSSYFS----TKIKSTiq---------------------------sSTDQTLIPDILRIISKIS 370 Trichomonas va...
A0BYN1        308 ------------FVKTFSQIIIDDL-QILNQNan--------------------------tlQGFIKLYEKIFSLYDKIA 348 Paramecium tet...
Q236H3        354 ------------FLNIFYKYVAHQT-SALAARq----------------------------sTPVKEYIEDIILFRLKII 392 Tetrahymena th...
12_pfamImport 298 ------------LGQKVRTYYQ----SCISQKckdakekisafk------pdktknirdftkETAIEWVKGLIEFKIFVD 355
EAY01000      311 --------IKS-FEPKFSDHMKlnd-----------------------------------kiTQIHEIIKKVLSQTEPFE 346 Trichomonas va...
A0CFE8        305 ------------FVRKFQEIIIQQG-QEIIVEqknrisqt---------------kikqekeDQKSKFLEQLISLQQSYK 356 Paramecium tet...
Q9XZJ3        299 --------LAP-VLETVQKYIQHVGiDAIKSIpdr-------------------------nnPDPKIYVETLLKIYLQFS 344 Dictyostelium ...
CBJ31794      319 ggavennaMKA-LEEVVRDHVRSVGlTVVKDLqakgamdvsddeagvrdndllpagggkaavVTSDDVVAAMLEVYEHYK 397 Ectocarpus sil...
Q24DT3        307 ------------LKKNWNQYIRRKG-EEIVNe------------------------------ENQDDITQHLLDFFHDLD 343 Tetrahymena th...
2HYE_C        374 HVI--EVCFQ------K-------NERFVNL---------MKESFETFI-Nk-----rPNKPAELIAKHVDS--KLR--- 418 human
XP_001313683  371 DFD--QFIFE------N-------SRDAVKT---------INESVSASMsSqr----dH--IAEYLARYIDSgnPLV--- 417 Trichomonas va...
A0BYN1        349 QYGnnEHQYK-----------------FHKA---------IKNAFEQVI-NkdnfimmE------LNIYFDF--LMK--- 390 Paramecium tet...
Q236H3        393 NIM--QEAFF------S----------LLKTddqltiqrqTQKSFEDSL-Nds----nF--PTEQLNCYIDE--AFQkdf 445 Tetrahymena th...
12_pfamImport 356 NQI--STLFS------N-------DLELQKA---------RDNAFQISLrEfk-------eSPHFLSQYCDD--LMKqq- 401
EAY01000      347 FVFcsQEHMRkksddpNfdmekeaREKFEKA---------ITAGWNIPAfN----------IVENFVQYIDF--HIKnek 405 Trichomonas va...
A0CFE8        357 KLI------------------------YDHAennqfllanLRVAFEMITaN----------AEQH--FIMES--LLQklh 398 Paramecium tet...
Q9XZJ3        345 SII--KKSFN------N-------DVSFITV---------LDLACHKIF-NqnhitrnTTKSPELLAKYCDM--LLK--- 394 Dictyostelium ...
CBJ31794      398 GLM--ADSFD------S-------SPGFRAV---------LDEACKSFV-Na------vPQASEWLARYAHC--LLD--- 441 Ectocarpus sil...
Q24DT3        344 III--QKCFE------N-------TNLLKQA---------KNYALEHVL-Sik---vnT--IAELTSKHIDT--KLKkqn 391 Tetrahymena th...
2HYE_C        419 Ag--nKEatDEELERTLDKI-MILFRFIH-GKDVFEAFYKKDLAKRLLVGKSASVDAE-KSMLSKLKHECGA-AFTSKLE 492 human
XP_001313683  418 Gp------------------sLILFKLID-ASEVFESTYFHLFGRRFLSWNVDV-QRE-NELIDTLQMNASK-EYTDRLV 475 Trichomonas va...
A0BYN1        391 Ket----lrDEEKKLQIDKG-FLIFKLVQ-SKDEFEQIYRKHLCVRLLDQTYSSLEVE-KDLLKKLRLECGS-VLTHKME 462 Paramecium tet...
Q236H3        446 Kn---KS--EQQIEEVLNSV-FEIFCLIR-NKDYFASIYMKSLAKRILYNKSLDENNE-KQIISKFKLECGT-VYTKKME 516 Tetrahymena th...
12_pfamImport 402 -------ltDHESNDRQIEV-NAIFDYMNtSRDEFLLHYQQALCRRLIGFTSKSMAAE-KQIVTKFKNSVGAlPTLNRLQ 472
EAY01000      406 Kr------lSKTENENFERTcARFFRYTE-DKVGFCTTYEQALLQRLIKFLTKF-DAEeRMMIETISKEKQP-EFMKGYK 476 Trichomonas va...
A0CFE8        399 Tft-lKRi-DIGEEKQLKEV-MQLLECFQ-AKDLLLRNYQNKLAQRILTLFDYHSDFD-KQIIDQFRKTYGP-EHTKQLE 472 Paramecium tet...
Q9XZJ3        395 Kg--nKQheEIELEEKLGQI-IVLFKYVD-DKDVFQKFYSKMLSRRLINGTSVSDDIE-KFMITGLKQACGF-EYTSKFQ 468 Dictyostelium ...
CBJ31794      442 KgfkeSKvdEGTRQESLDHV-GFLFAYIA-DKDIFHKYYSKLLSKRIIQLTSVSDEAE-ERMLKNMRKISGF-EYTSKLQ 517 Ectocarpus sil...
Q24DT3        392 Ktm----qdHDQIEKDVDDA-LELFRYLP-AKDIFEAFYNKRLARRLLMNLAYSYELE-RKVLDRLRSECGD-QYTMKAD 463 Tetrahymena th...
2HYE_C        493 GMFKDMELSKDIM------V-HFKQHMQn----QSDsgpID------LTVN----------------------------- 526 human
XP_001313683  476 KTINDYNQSKRILqptsdgM-EYKA----------------------M-------------------------------- 500 Trichomonas va...
A0BYN1        463 TMFSDLERSSEDS------Q-KFRQKLS-----QNQrdsID------LDIL----------------------------- 495 Paramecium tet...
Q236H3        517 TMFLDMQQSLEYY------N-EFKQLFIknlntKSAyksLD------FDIK----------------------------- 554 Tetrahymena th...
12_pfamImport 473 NMLTDVETNE-----------QYNK---------------EkvqndiLKIY----------------------------- 497
EAY01000      477 DLKACIDNSAQID------D-DFKK-----------------------QI------------------------------ 496 Trichomonas va...
A0CFE8        473 SMIKDYEQQKNEE------KiTISD--------------IE------IQAK----------------------------- 497 Paramecium tet...
Q9XZJ3        469 RMFNDITLSAETN------E-EFKNHLIk---nSLSigkID------FSIL----------------------------- 503 Dictyostelium ...
CBJ31794      518 RMFVDKTLSRDLH------T-GYVE----------W------------QVRgggigggggggrgggggwgggglgagaeg 568 Ectocarpus sil...
Q24DT3        464 EILKDVNESKQLN------K-DFNDY--------LSsqgLDynkkniFSCI----------------------------- 499 Tetrahymena th...
2HYE_C        527 ----------------------ILTMGYWPTYTPM-E------------------VHLTPEMIKLQEV-FKAFYLG--K- 561 human
XP_001313683  501 ----------------------ALYERDWSTNEGE--------------------IKFPEQIEILNEE-FKKRYMKqqKt 537 Trichomonas va...
A0BYN1        496 ----------------------VLTSEQWPITDSQp-------------------IIIHTELLLWQQQ-FTQYYQS--K- 530 Paramecium tet...
Q236H3        555 ----------------------VLTCGNWPYKLNQfSq-----------------VKIPNQLEPYISE-FEKHYKS--K- 591 Tetrahymena th...
12_pfamImport 498 ----------------------VLNSVAWPLKRNElEk-----------------IIFPSSFAGIIDQ-FTKQYNQ--T- 534
EAY01000      497 ----------------------MNTKIEWPDGMREvQfspivfnknhyklyiieqTKIPEFLSPVHDR-FIQFYQE--K- 550 Trichomonas va...
A0CFE8        498 ----------------------ILQKEYWPEIRPQlNld---------------nILILNQLKAAYREkFNSQQEK---- 536 Paramecium tet...
Q9XZJ3        504 ----------------------VLTSGSWS--LHsqt----------------ssFIVPQELTLCISA-FQQYYST--Q- 539 Dictyostelium ...
CBJ31794      569 eggfvypaglvqlpmhfeaftfVLTAGCWP--LQsvs----------------ssFKPPAPIEDYVVS-FLDFYSE--V- 626 Ectocarpus sil...
Q24DT3        500 ----------------------VVSSSAWPMKNQQlP-------------------ILFEPFDKFQKE-FKKFYEL--K- 534 Tetrahymena th...
2HYE_C        562 HSGRKLQWQTTLGHAVLKAEFKE-----GKk--EFQVSLFQTLVLL-MF-Ne-GD---GFSFEEIKMATGIEDSELRRTL 628 human
XP_001313683  538 DSHIVLHFSAALSNCVLKVNNKS----------EIKMSGEQAIIVL-LL-----SekgPMNVDDIHNHTGINESQIKINL 601 Trichomonas va...
A0BYN1        531 NSKRKLSFNYGLGSVSLKATFDQ------NskkDFVCSVFQATILM-HF-NkqR----VYKVDELIKLTNSDKEIMQYEL 598 Paramecium tet...
Q236H3        592 FKGRKLKWIYSVGKSIVKG-YYSf----NNskkEFQVSNVQMVILL-LF-NnkI----KYTQQELTALLQMPYEEYKLHL 660 Tetrahymena th...
12_pfamImport 535 YKQRKIFWLFNEGSAEINF-TSAnk-ktFAgkyILRTTSYQMLILM-KM-NekA----SITIQDLMDQTGINKDSFDNNL 606
EAY01000      551 NKSMTLMLLADTSTVQSKWRIPKnsksnKPetyVLTTDILTSKILSyLHkNqtE----KVSVQDIIMYTQEEKPLVKKCI 626 Trichomonas va...
A0CFE8        537 NQLIDISWQDQLSMVELMFRTNQe--------yKVIIGVVGGAILL-QF-N---HqnnPQTSEQLAQSIGVNNQYFLNQI 603 Paramecium tet...
Q9XZJ3        540 HQGRKLNWLHHLCKAEAKSFFAK------Ksy-dFQVTNFQLGILL-IF-Nt-qE---SVSLEEITKFTNLNENELSRTL 606 Dictyostelium ...
CBJ31794      627 HSGRKLEWLYHLGHGEMVTHCFD------Kty-rIYSSTFQMGLLH-QF-Nd-sT---EIAVSELARGINVSDTEIVRHL 693 Ectocarpus sil...
Q24DT3        535 HKGVCINWQHETSTCDIQGNYNKek-------yIFQVQLIQGLILL-CF-Nlk----nKLSYTEIHNLVQIDEEELKKNL 601 Tetrahymena th...
2HYE_C        629 QSLACGK--AR-V---LIKSP--------KG-K-EVED-GDKF------IFNGEF 660 human
XP_001313683  602 DIL--SKkpLN-L---LIKg------------D------DDKW------SVNKDA 626 Trichomonas vaginalis G3
A0BYN1        599 ENL---------LqfkLLI---------------QNEE-ENSL------QLNQKF 622 Paramecium tetraurelia
Q236H3        661 LPL---------VqlkILK-----------SeN------NIDF------EYNDQF 683 Tetrahymena thermophila SB210
12_pfamImport 607 KQL---------IklkILS-----------CaE------EDKYtesstvQVNAQF 635
EAY01000      627 AKL---------LglqICV-RektvktteKQqQqQLSD-TDLI------MMNKEF 664 Trichomonas vaginalis G3
A0CFE8        604 KLLe-----SKkL---LTRD-------------------GQAY------KFNEEF 625 Paramecium tetraurelia
Q9XZJ3        607 QSLi----eAK-I---LIS-------------K-KKDQ-NSIN------NNNNNN 632 Dictyostelium discoideum
CBJ31794      694 FPLi----kAG-L---LRLHGadgadlkpTScD-DIPP-GARA------RLNASF 732 Ectocarpus siliculosus
Q24DT3        602 VSLYAMKdtQK-L---LNK-----------SgEaKRVDeTDVF------EVNEAY 635 Tetrahymena thermophila SB210
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