2ABK,1N39,2H56,3S6I,4HSB,2JHJ,1KG7,3N5N,1PU8


Conserved Protein Domain Family
HhH-GPD
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pfam00730: HhH-GPD 
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HhH-GPD superfamily base excision DNA repair protein
This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.
Links
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Statistics
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PSSM-Id: 425841
Aligned: 50 rows
Threshold Bit Score: 89.6507
Created: 16-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2ABK_A  34 IAVLLSAQATDVSVNKATAKLYPVa----nTPAAMLELG-VEGVKTYik----tiGLYnSKAENIIKTCRILLEQHNGEV 104 Escherichia coli
O06554  25 VGMLLDQQVPMETAFAGPKKIADRmg--sfDAGDIADYD-PDKFVALcserpaihRFPgSMAKRIQALAQIIVDRYDGDA 101 Mycobacterium tubercu...
O24954  36 ISEVMSQQTQ---INTVIERFYSPfleafpTLKDLANAQ-LEEVLLLwr----glGYY-SRAKNLKKSAEICVKEHHSQL 106 Helicobacter pylori
Q9JYW9  38 lSEIMLQQTQVATVLDYYPRFLEKf----pTVQTLAAAP-QDEVLSLwa----glGYY-SRARNLHKAAQQVVRQFGGTF 107 Neisseria meningitidi...
1KG7_A  35 LSEVMLQQTQVATVIPYFERFMARf----pTVTDLANAP-LDEVLHLwt----glGYY-ARARNLHKAAQQVATLHGGKF 104 Escherichia coli
P44320  40 LSEVMLQQTQVATVIPYFERFIKTf----pNITALANAS-QDEVLHLwt----glGYY-ARARNLHKAAQKVRDEFNGNF 109 Haemophilus influenza...
O83363  42 VSEFMLQQTQTERVCPKYAEWLHRf----pSLESLACAP-FAHVLQAwi----glG-YnRRARFLHQSAKLIVERYCAVV 111 Treponema pallidum
O84109  42 VSEVMLQQTRAEVVVPYFLKWMERf----pTLQDLAQAR-ESDVVQLwe----glGYY-SRARNLLAGARVITEIFGGEI 111 Chlamydia trachomatis
3N5N_Y  54 VSEVMLQQTQVATVINYYTGWMQKw----pTLQDLASAS-LEEVNQLwa----glGYY-SRGRRLQEGARKVVEELGGHM 123 human
Q10159  67 VSEIMLQQTRVETVKRYYTKWMETl----pTLKSCAEAEyNTQVMPLws----gmGFY-TRCKRLHQACQHLAKLHPSEI 137 Schizosaccharomyces p...

2ABK_A 105 PEDRAALEa----------------------------lPGVGRKTANVVLNTAFG--Wp-TIAVDTHIFRVCNRTQFAPG 153 Escherichia coli
O06554 102 AALWTAGEpdgnellrrlkglpgfgeqkariflallgkQYGVTPKGWQVAAGEFGqpGtyLSVADIVDAGSLGQVRSHKR 181 Mycobacterium tubercu...
O24954 107 PNDYQSLLk----------------------------lPGIGAYTANAILCFGFR--Ek-RACVDANIKRVLLRLFGLDP 155 Helicobacter pylori
Q9JYW9 108 PSERKDLEt----------------------------lCGVGRSTAAAICAFSFNrrE---TILDGNVKRVLCRVFARDG 156 Neisseria meningitidi...
1KG7_A 105 PETFEEVAa----------------------------lPGVGRSTAGAILSLSLGk---hFPILDGNVKRVLARCYAVSG 153 Escherichia coli
P44320 110 PTNFEQVWa----------------------------lSGVGRSTAGAILSSVLN--Qp-YPILDGNVKRVLARYFAVEG 158 Haemophilus influenza...
O83363 112 PDDPSELK------------------------------KLPGVGDYTAAAVACFAynKa-TVFLETNIRAVFIRFFFP-- 158 Treponema pallidum
O84109 112 PNDLALLS------------------------------SIKGIGSYTANAILAFAfkQk-NPAVDGNVLRVMSRLFAIEE 160 Chlamydia trachomatis
3N5N_Y 124 PRTAETLQql---------------------------lPGVGRYTAGAIASIAFG--Qa-TGVVDGNVARVLCRVRAIGA 173 human
Q10159 138 PRTGDEWAkg---------------------------iPGVGPYTAGAVLSIAWK--Qp-TGIVDGNVIRVLSRALAIHS 187 Schizosaccharomyces p...

2ABK_A 154 -KNVEQVEEKLLKVVPA 169 Escherichia coli
O06554 182 q---RKAAAKA-EGKAP 194 Mycobacterium tuberculosis
O24954 156 nIHAKDLQIKANEFLNL 172 Helicobacter pylori
Q9JYW9 157 nPQDKKFENSLWTLaes 173 Neisseria meningitidis serogroup B
1KG7_A 154 wPGKKEVANKLWSLSEQ 170 Escherichia coli
P44320 159 wSGEKKVENRLWALTEQ 175 Haemophilus influenzae Rd KW20
O83363 159 -DTHQVSDRELLSLVRC 174 Treponema pallidum
O84109 161 sIDRMNTRREITGLCES 177 Chlamydia trachomatis
3N5N_Y 174 dPSSTLVSQQLWGLAQQ 190 human
Q10159 188 dCSKGKANALIWKLANE 204 Schizosaccharomyces pombe 972h-
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