2C9A,4GWN


Conserved Protein Domain Family
MAM

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pfam00629: MAM 
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MAM domain, meprin/A5/mu
An extracellular domain found in many receptors. The MAM domain along with the associated Ig domain in type IIB receptor protein tyrosine phosphatases forms a structural unit (termed MIg) with a seamless interdomain interface. It plays a major role in homodimerization of the phosphatase ectoprotein and in cell adhesion. MAM is a beta-sandwich consisting of two five-stranded antiparallel beta-sheets rotated away from each other by approx 25 degrees, and plays a similar role in meprin metalloproteinases.
Statistics
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PSSM-Id: 425786
Aligned: 56 rows
Threshold Bit Score: 107.835
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2C9A_A          7 CLFDEPysTCG-Y-SQSEGDDF-NWEQV--------NTLTKPTSDPW--XPSGSFXLVNAS-Gr-PEGQRAHLLLPQLKE 71   human
Q6UXC1        493 TDFESPe-AGG-W--EDASVGRlQWRRVs------aQESQGSSAAAA-----GHFLSLQRAwG--QLGAEARVLTPLLGP 555  human
A2AJA7        494 TDFESAs-AGG-W--EDISVGKlQWQWVe------aQEKSKPAGDANr-DAPGHFLSLQKAwG--QLRSEARALTPALGP 560  house mouse
Q9UM73        480 CNFEDG--FCG-WtQGTLSPHTpQWQVR--------TLKDARFQDHQ-----DHALLLSTT-DvpASES-ATVTSATFPA 541  human
2_pfamImport    1 CNFEAG--LCH-Y-TLDNVAGS-SWRRVl------vKRNIFQNGDHTt-GTAGSFLLAHSQs--rHSGYISRLIGQTLPG 66  
Q8CG85        342 CDFEIG--LCN-F-YQDKEGP--GWTRVr------vKANMYRAGDHT--TGTGHYLLANTK-FtsQPGYIGRLYGPSLPG 406  house mouse
Q63191        273 TDFETG--LGP-W-TQLE-----GWTRNfsa--gsmVSPAWPHRDHSrnSAYGFFLVSVA-----KPGTTAVLYSPEFQG 336  Norway rat
Q6UXC1        271 TDFETG--LGP-W-NRSE-----GWSRNhra--ggpERPSWPRRDHSrnSAQGSFLVSVA-----EPGTPAILSSPEFQA 334  human
4_pfamImport    1 CDFDDG--SCG-W-FELTPGDGfDWVRGtsaevpphFYGYPPPLDHTtsSTEGHFMFILKN-SssLYPQ-AVLQGPWFRQ 74  
AAP91727        7 CSFNWG--LCGgW---FASSAHlDWFFSp-------SVNTSTLREHT--GNGGYYAGVLAV-AgrPHGSTAVLTSPPIPL 71   vase tunicate
2C9A_A         72 NDT--HC-IDFHYFVSsksNSP-PGLLNVYVKVNNGPl--gNPIWNIS-GDPT-RTWNRAELAISTfwPNFYQVIFEVI- 142  human
Q6UXC1        556 SGP--SCeLHLAYYLQ---SQP-RGFLALVVVDNGSR----ELAWQAL-SSSA-GIWKVDKVLLGAr-RRPFRLEFVGLv 622  human
A2AJA7        561 SGP--HCeLHMAYYFQ---SHP-QGFLALVVVENGFR----ELLWQAP-GGGS-GSWTEEKIILGAr-RRPFQLEFVSLv 627  house mouse
Q9UM73        542 PIKssPCeLRMSWLIR---GVL-RGNVSLVLVENKTGkeqgRMVWHVA-AYEGlSLWQWMVLPLLDv-SDRFWLQMVAWw 615  human
2_pfamImport   67 NMK--YC-LRFFYSLSagfNQT-HSALMVYVQQQQSGt--qEKIWTQGeKSRG--IWIAADVTFQI--SQPAKLVFISSc 136 
Q8CG85        407 NMQ--YC-VRFHYAIFgflKMS--DTLAVYIFEENHVv--qEKIWSVLeSPRG--VWMQAEISFKK--PMPTKVVFMSLc 475  house mouse
Q63191        337 SVSy-NCsFTFYYYLH---GSE-ANQFQLFVQAQGLNttqpPVLLRSRhGELG-TAWVRDRVNIQS--AHPFRILLAGE- 407  Norway rat
Q6UXC1        335 SGTs-NCsLVFYQYLS---GSE-AGCLQLFLQTLGPGapraPVLLRRRrGELG-TAWVRDRVDIQS--AYPFQILLAGQ- 405  human
4_pfamImport   75 SAS--GCtMTFWHYNS---GIS-VGAANMNLRIKGDPn--nTVIWRTL-YDQG-PQWKQTTVQLGRl-TQPFQISLSKIs 143 
AAP91727       72 TAEqvYC-VDYWVRTS---SDYsRARVRVNSKLPGNT-----TLLSRC-QVQT-PNWKNCGALITPnvTDVYQIEIDVIf 140  vase tunicate
2C9A_A        143 --TSGHQGYLAIDEVKvLGHPCT 163  human
Q6UXC1        623 dlDGPDQQGAGVDNVTl--RDCS 643  human
A2AJA7        628 dlDGPGQQGAGVDNVTl--RDCN 648  house mouse
Q9UM73        616 --GQGSRAIVAFDNIS-ISLDCY 635  human
2_pfamImport  137 -rDIWDCNSVALDDISlNLGDCN 158 
Q8CG85        476 -kSFWDCGLVALDDITiQLGNCR 497  house mouse
Q63191        408 ---TGPGGFVGLDDLI-MSNHCI 426  Norway rat
Q6UXC1        406 ---TGPGGVVGLDDLI-LSDHCR 424  human
4_pfamImport  144 --LGVFDGVSALDDVTf--SNCS 162 
AAP91727      141 --ETVPEFTFLFDDITiYPGRCR 161  vase tunicate
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