5JCP,3KUQ,3MSX,1RGP,5C2J,5IRC,3IUG


Conserved Protein Domain Family
RhoGAP

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pfam00620: RhoGAP 
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RhoGAP domain
GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
Statistics
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PSSM-Id: 459875
Aligned: 83 rows
Threshold Bit Score: 91.8377
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5JCP_B     24 PIIVDACISFVTQHG-LRLEGVYRKGGARARSLRLLAEFrRDARSVKl--RPGEHFVEDVTDTLKRFFRELDDPVTSaRL 100 human
O74335     68 PAVVAKCGFFLKQNA-TQVKGIFRVNGSSKRIQILQKAFsTGPDYGRs-fDWEGYTVHDAANVFRRFINLMPEHVIPlEY 145 Schizosaccharomyce...
Q12128     76 PVVIAKSGKYLKENA-LDTTGIFRIAGSNKRVRELQAVFsKPPDYGRkfeGWCDFNVHDIATLLKRYLNSLSEPLVPlAL 154 Saccharomyces cere...
Q8STW6    162 SPVVFSVVKSLKKRA-IRTKFIFRYEPDKLAAAKIANKIhENTCVDIe-----NIDVLVLANALKNYIREHLDGLVPiEA 235 Encephalitozoon cu...
Q8IJX0    275 PSILIDFLTHLKKPEiINTKDLFNLQADAATLYGIVGDIe-YGEP-----TTDFNNIPSLVCSFKLFLNTQKHGLLGkDA 348 Plasmodium falcipa...
Q9VUR5     55 PGPLLVLILKLNKES-PNRRDVFRAPGHQGAMKKLIHFLqAGRLV-----NVDNYSVFTIASVLKKFLRKIPNGIFGrSG 128 fruit fly
3MSX_B     27 PKPVLDMLFFLNQKG-PLTKGIFRQSANVKSCRELKEKLnSGVEV-----HLDCESIFVIASVLKDFLRNIPGSIFSsDL 100 human
NP_082215 380 PAPVLDMLSIIDAKG-PDTERIFRTLANKPYLT-LREKLdSAEEM-----NLREESVYIVASVLKEFIRNIPGSLLCsNL 452
Q8N103    101 PRPIQDILTILCLKG-PSTEGIFRRAANEKARKELKEELnSGDAV-----DLERLPVHLLAVVFKDFLRSIPRKLLSsDL 174 human
Q9XW53    264 PQPIMTIVDHLRMDG-FDAEGIFRKSPKQSTFKELKCELdKGVVP-----DFHKYNTHVLASILKEYLRSIPGKILLsGN 337 Caenorhabditis ele...
5JCP_B    101 LPRWRE-AAEL--P-----QKN--QRLEKYKDVIGCLPRVNRRTLATLIGHLYRVQKCAA--LNQMCTRNLALLFAPSVF 168 human
O74335    146 YERFRE-PMTI--P-----NLTdnERVEMYRRRIDELPIPNRQLLLYLLDLLSVFAMNSS--KNLMTADNLAAIFQPGIL 215 Schizosaccharomyce...
Q12128    155 YDIFRN---PIleNpkineHKE--QIIKDYEDIYMLLPQQNRHLILYLAALLNLFARNEK--KNLMSASNLAAIVQPSLL 227 Saccharomyces cere...
Q8STW6    236 FEKIKT-CIIS--N-----DRY--TREALFSYMPFIFTDAERRLLTSLFELLKMIDKNSD--ATEMNIDSLLGLFSLVLH 303 Encephalitozoon cu...
Q8IJX0    349 FSRLHY-LKST--S-----ASDkvIKLN-LSKLYEKLSQGIKQCVLCLLHFFKTISEHAS--ENNMTILALSKIFAPTFF 417 Plasmodium falcipa...
Q9VUR5    129 EMELFA-INDL--Q-----NEA--EQTERLHRLFGSLPKYTQHLLVLLFGTFRVIASNAAhaSTGMTSEALGVSVAPSFF 198 fruit fly
3MSX_B    101 YDHWVS-VMDQ--G-----NDE--EKINTVQRLLDQLPRANVVLLRYLFGVLHNIEQHSS--SNQMTAFNLAVCVAPSIL 168 human
NP_082215 453 YGKWLA-VL----D-----QEFhdQKISAIQSLLIQMPLPNVLLLRHLLSVLHKIKGRSS--ITHMTAYALSVRIAPSML 520
Q8N103    175 FEEWMG-ALEM--Q-----DEE--DRIEALKQVADKLPRPNLLLLKHLVYVLHLISKNSE--VNRMDSSNLAICIGPNML 242 human
Q9XW53    338 YELWMReIADE--P-----NTE--KKVSCCRALLSHLPTSHSILLANVLKLLNKISNSP---SSKMNASSLSVCLAPSFL 405 Caenorhabditis ele...
5JCP_B    169 QTDG 172 human
O74335    216 SHPD 219 Schizosaccharomyces pombe 972h-
Q12128    228 SHPK 231 Saccharomyces cerevisiae S288C
Q8STW6    304 PQAA 307 Encephalitozoon cuniculi
Q8IJX0    418 RSKT 421 Plasmodium falciparum 3D7
Q9VUR5    199 QSCV 202 fruit fly
3MSX_B    169 WPPA 172 human
NP_082215 521 WNPS 524
Q8N103    243 TLEN 246 human
Q9XW53    406 ESPD 409 Caenorhabditis elegans
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