4WPC,2EFK,5C1F


Conserved Protein Domain Family
FCH

?
pfam00611: FCH 
Click on image for an interactive view with Cn3D
Fes/CIP4, and EFC/F-BAR homology domain
Alignment extended from. Highly alpha-helical. The cytosolic endocytic adaptor proteins in fungi carry this domain at the N-terminus; several of these have been referred to as muniscin proteins. These N-terminal BAR, N-BAR, and EFC/F-BAR domains are found in proteins that regulate membrane trafficking events by inducing membrane tubulation. The domain dimerizes into a curved structure that binds to liposomes and either senses or induces the curvature of the membrane bilayer to cause biophysical changes to the shape of the bilayer; it also thereby recruits other trafficking factors, such as the GTPase dynamin. Most EFC/F-BAR domain-family members localize to actin-rich structures.
Statistics
?
PSSM-Id: 425777
Aligned: 528 rows
Threshold Bit Score: 30.3141
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
4WPC_A         28 AINALLSRLKQSLLTCEEFMKFIRKKYAFEEEHVQELSKQYKHFFNiQ---GS---Tn--SSLKKMIHEVLGFDGKMAQV 99  Saccharomyces ...
ESO02102       10 QFDSLAFHTSKGIEFCDRFAQFIKERCVVENEYAAKLKKLVKNFQPkK---KEd--Da-eWTSLKGFCCMITEVHDIAGQ 83  Helobdella rob...
26_pfamImport   1 QFDNISSHTQKSYDLCEKVMQFYKERCNIENDYANKLKKLAKSVSTkK---KD---Dd-eFTCQKGFQLSTKELNDMAGQ 73 
PDM73325       44 QTDAVANHTSKGIEFLEKVGTLCKERAAIEEEYASKLRSLVKRNIG-KkkdED---Ag--FTYITAFNLILKEMDALAGQ 117 Pristionchus p...
Q19253         13 QQGTLNEYTGKGIDLLERIMAYSKERASIELEYSSKLKALSKKTAMkMk--SEselWn-sVSYVKGFHDVIAGIVPVATQ 89  Caenorhabditis...
EGT54851       61 QQHTLNEYTGKGIDVMERIVTYAKERAAIELEYSAKLKTLAKKTVMkMk--NEs-eLwntVTYVKGFHDYINGIYPIAAQ 137 Caenorhabditis...
CAP34060       23 AVSQINDYTGKGIEYIERIGSLAKDRAVIENEYSSKMRALIKKHGIrPk--GQeteLmnsVSFIRGYYDFVAGLQPIAAQ 100 Caenorhabditis...
EGT34688       13 PSNALLSYTQKGIEFFEKIGQFSKEKAAIEEEYSSKLKNLSKKYAKkAe--EDdeiLk-sVTYIGSFNTYLQQVDQIAGK 89  Caenorhabditis...
Q9XUS7         13 PSNALLSYTQKGIDFFEKLGQFSKEKAAIEEEYSTKLRSLAKKYAKkSe--EDdeiLk-sVSYTSSFNSFLQQLDQIATR 89  Caenorhabditis...
22_pfamImport   1 SSNTLLSYTQKEIDFFEKLGSFSKEKAAIEEEYSAKLRNLAKKYAKkAd--EEneiWk-sVGYVAAFNSILHQIDQIAAR 77 
4WPC_A        100 KQS 102 Saccharomyces cerevisiae S288C
ESO02102       84 HEM 86  Helobdella robusta
26_pfamImport  74 HEA 76 
PDM73325      118 HEV 120 Pristionchus pacificus
Q19253         90 HEL 92  Caenorhabditis elegans
EGT54851      138 REL 140 Caenorhabditis brenneri
CAP34060      101 HEI 103 Caenorhabditis briggsae
EGT34688       90 HHA 92  Caenorhabditis brenneri
Q9XUS7         90 HQT 92  Caenorhabditis elegans
22_pfamImport  78 FHS 80 
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap