3QVA,2IGL,2H1X,4Q14,5Z5M,2H0F


Conserved Protein Domain Family
Transthyretin

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pfam00576: Transthyretin 
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HIUase/Transthyretin family
This family includes transthyretin that is a thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain. However, most of the sequences listed in this family do not bind thyroid hormones. They are actually enzymes of the purine catabolism that catalyze the conversion of 5-hydroxyisourate (HIU) to OHCU. HIU hydrolysis is the original function of the family and is conserved from bacteria to mammals; transthyretins arose by gene duplications in the vertebrate lineage. HIUases are distinguished in the alignment from the conserved C-terminal YRGS sequence.
Statistics
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PSSM-Id: 459857
Aligned: 326 rows
Threshold Bit Score: 98.6703
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3QVA_C             12 LSTHILDISTGTPAEGVTVSLSREGEt----lANLVTNAQGRIATFSa--APLPAGRYCLTAETGAWFARAGRe-----s 80  Klebsiella...
jgi:Mrad2831_5848  77 LTLHAIDNFHGTPGAGMVCDLALHDGdgyrliKTVTTAPNGRTAEPLlvdEAFKPGRYELVMHVEAYFAGLGVklp-tpn 155
CAS:CtCNB1_0866    58 LTMHAVDTFHGSAATGLRIDFSRFDGetyvpiRSFVVNANGRADEPLlidDSYRSGRYEMLLHVDEYFAAKGAklp-rpa 136
Q0K2I8             56 LTLHALDTYNGTPAAGMRVEMFRIDNgqrtplQTVTLAANGRSEPPLligDSYRTGTYELVLHADEYFAARKAslp-qps 134 Cupriavidu...
jgi:Glo7428_4240    5 ISIHVVDVTRGLPAAGMKVEIFKVgge---kiAAGVLSHQGLLDHSVvrgENVELGNYKVVFHIGQFYCQLGYalpeefp 81 
WP_011924042        5 ISVHAVDVANGRPALGLRVAIWRVAPdrt-llAEGLLGADGTLQAPVvkgDGVTAGEYEVLFHIGEFFGAEARt-----k 78  Bradyrhizo...
Q89Q47             25 ISIHAVDVASGRPAQGLRVEIWRIDPdss-riADGRLGANGVLDHPIvqgAGVTAGEYEVLFHLGEFFADSDG------- 96  Bradyrhizo...
BAF87966            7 ISIHGVDIAQGVAARGLQVKVYALDPerr-liTEGVLGANGVFDDPIitgAGITAGTYEVEFALGAWLKANGYgar-eaa 84 
WP_014241821        5 ISLHAVDVARGVPAEGMRVELYALRDgqrnrlAESRLCANGALDHPVvggDGVTAGVYEAVFHIGPWLRAQGAgaa-epa 83  Azospirillum
WP_012333793        6 ISVHAVDVATGRPAAGLRVTVEALDPagrrlvAEGRIGPDGHLPHPIsggAGVTAGIYEVTFDVGDYLAPEGGg-----r 80  Methylobac...
3QVA_C             81 VFTRAQIDFVIGeAAeDHFHLPFLIAPGGWSTYRG 115 Klebsiella pneumoniae subsp. pneumoniae MGH 78578
jgi:Mrad2831_5848 156 FLGLVPIRFRIR-DAsQRYHLPVLFTPWGYSYYRG 189
CAS:CtCNB1_0866   137 FLSKVPVRFQIV-NTaERIHLPIQFGPWSYTYSRG 170
Q0K2I8            135 FLSKIPLRLRVT-DAsQRIHLPVLFGPWSYNYYRG 168 Cupriavidus necator H16
jgi:Glo7428_4240   82 FLYVVPFRFGVS-DVeQHYHLPLKVSPWGFSLFRG 115
WP_011924042       79 FLTTVPFRFAID-KVeEHFHLPLKFTPWGYSIFRG 112 Bradyrhizobium sp. ORS 278
Q89Q47             97 FLTVTPFRFRIK-NVdEHFHLPLKFTRWGYSLFRG 130 Bradyrhizobium japonicum
BAF87966           85 FLDIVPFRFVVT-RVeEHYHLPFKFTPWGIQLFRG 118
WP_014241821       84 FLEEAPFRFTVT-DVeQHYHLPLKFTPWGYSLFRG 117 Azospirillum
WP_012333793       81 FLDRVPFRFTIE-DVaAHVHLPLKFTRFGYALFRG 114 Methylobacterium sp. 4-46
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