1LE5,1BVO


Conserved Protein Domain Family
RHD_DNA_bind
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pfam00554: RHD_DNA_bind 
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Rel homology DNA-binding domain
Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal DNA-binding domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See pfam16179) that functions as a dimerization domain.
Links
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Statistics
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PSSM-Id: 425749
Aligned: 21 rows
Threshold Bit Score: 141.288
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1LE5_E    4 VEIIEQPKQRGMRFRYKCE-GRSAGSIPGERSTDTTKTHPTIKINGYTG-PGT-VRISLVTKDPP-HRPHP----HELVG 75   house mouse
O96458   62 LKILEQPRQRGFRFRYGCE-GPSHGGLPGQNSQRGKRSFPSVEICNYKG-SAR-IVVSLVTNEET-PRPHA----HSLVG 133  purple sea urchin
P98150   39 LVIIEQPKQRGFRFRYVCE-GPSHGGLPGASSEKGHKTYPTVKICNYEG-MAR-IEVDLVTHSDP-PRVHA----HSLVG 110  chicken
O73630   45 LSIIEQPKQRGFRFRYVCE-GPSHRGLPGASSEKGKKTFPTVKIFNYVG-MAR-IEVDLVTHTDP-PRVHA----HSLVG 116  African clawed frog
O77638  418 LRIEVQPKSH-HRAHYETE--GSRGAVKA-----SAGGHPSVQLHGYVEsEPLtLQLFIGTADDRlLRPHAfyqvHRITG 489  pig
Q8MV44  135 LTIVEQPVDK-FRFRYQSEmHGTHGSLMGVHTEKSKKTFPTVQLHGFQG-EAK-IRCSLFQVDPNrRAAHS----HNLVI 207  yellow fever mosquito
Q94527  152 LRIVEQPVEK-FRFRYKSEmHGTHGSLNGANSKRTPKTFPEVTLCNYDG-PAV-IRCSLFQTNLD--SPHS----HQLVV 222  fruit fly
P19838   44 LQILEQPKQRGFRFRYVCE-GPSHGGLPGASSEKNKKSYPQVKICNYVG-PAK-VIVQLVTNGKN-IHLHA----HSLVG 115  human
Q962A4   85 VEIVEQPKQRGLRFRYECE-GRSAGSIPGEGSTSEKKTFPTIKIHNYTG-TAV-IVVSCVTKDQP-YEPHP----HNLVG 156  Pacific oyster
1BVO_A    3 VEITEQPHPKALRFRYECE-GRSAGSIPGVNTTAEQKTFPSIQVHGYRG-RAV-VVVSCVTKEGPeHKPHP----HNLVG 75   African malaria mos...

1LE5_E   76 K---D-CRDG------YYEADLCPD-RSIHSFQNLGIQCVKKRDLEQAISQRI--------------------------- 117  house mouse
O96458  134 K---H-CKDG------LCTVQVGPK-DMTASFPNLGILHVTRKDVVPTLKTRIlaqhrlykdl----------innstpg 192  purple sea urchin
P98150  111 K---QcNEAG------NCVAIVGPK-DMTAQFSNLGVLHVTKKNMMEIMKEKLkkqkt-------------------rnt 161  chicken
O73630  117 K---HsNKTG------NCIVTVGPE-DMTAQFNNLGIVHVTKKSQTEILKEKMkrnilr------------------ntg 168  African clawed frog
O77638  490 KtvsTtSHEAvlsntkVLEIPLLPEnNMRAIIDCAGILKLRNSDIELRKG------------------------------ 539  pig
Q8MV44  208 K-------SGeidlndPHDIDVNEEcNYVAMFQGMGIIHTAKKNIAEELSKKMkkqrs-------------------vem 261  yellow fever mosquito
Q94527  223 R------KDDrdv-cdPHDLHVSKErGYVAQFINMGIIHTAKKYIFEELCKKKqdrlvf------------------qmn 277  fruit fly
P19838  116 K---H-CEDG------ICTVTAGPK-DMVVGFANLGILHVTKKKVFETLEARMteacirgynpgllvhpdlaylqaeggg 184  human
Q962A4  157 R---D-CKRG------VCTLKVKD--TNVISFPHLGIQCAKKKDVENNLKQRK--------------------------- 197  Pacific oyster
1BVO_A   76 K---EgCKKG------VCTVEINST-TMSYTFNNLGIQCVKKKDVEEALRLRQ--------------------------- 118  African malaria mos...

1LE5_E  118 --QTNNNPFH-VPIEEQRG--DYDLNAVRLCFQVTV--RDPAGRPLLLTPVLSHPIFDN 169  house mouse
O96458  193 esHWTEPSDAeIEKKAKEMakDMDLSVVRLCFQTYLp-DISGHFTRPLDPVISVPVFDS 250  purple sea urchin
P98150  162 ngLLTEAELReIELEAKELkkVMDLSIVRLRFTAYLr-DSSGNFTLALQPVISDPIHDS 219  chicken
O73630  169 rnTLTEVEERkIEQEVKDLkkVTDLSIVRLKFTAYLp-DSNGAYTLALPPVISDPIHDS 226  African clawed frog
O77638  540 --ETDIGRKN---------------TRVRLVFRVHI---PQPNGRTLSLQVASNPIECS 578  pig
Q8MV44  262 nrELTLREEYqLQKEAAEMakTMNLNQVCLCFQAFQvdASTGRWAQLCEPVYSNPINNM 320  yellow fever mosquito
Q94527  278 rrELSHKQLQeLHQETEREakDMNLNQVRLCFEAFKi-EDNGAWVPLAPPVYSNAINNR 335  fruit fly
P19838  185 drQLGDREKElIRQAALQQtkEMDLSVVRLMFTAFLp-DSTGSFTRRLEPVVSDAIYDS 242  human
Q962A4  198 --EINVDPFQ-SGFKHLNKinSIDLNVVRLCFQVFLp-DENGKITRIVPPVVSHCIHDK 252  Pacific oyster
1BVO_A  119 --EIRVDPFR-TGFGHAKEpgSIDLNAVRLCFQVFLegQQRGRFTEPLTPVVSDIIYDK 174  African malaria mosquito
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