2W90,2JKV,4GWG,2P4Q,1PGJ


Conserved Protein Domain Family
6PGD

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pfam00393: 6PGD 
6-phosphogluconate dehydrogenase, C-terminal domain
This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase. The domain contains two structural repeats of 5 helices each.
Statistics
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PSSM-Id: 459797
Aligned: 331 rows
Threshold Bit Score: 283.961
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2W90_A       180 GHYVKMVHNGIEYGDMQLIAEAYFLLKHVLGMDAAELHEVFADWNKG-EL-NSYLIEITADIFTK-------IDe--ETG 248
EOA86519     184 GHYVKMMHNGIEHGMMSAICEAWGIMRK-MGMGYEEIGDVFAQWNSEgELrGTFLISIGADLSH--------KReagDl- 253
EGP90829     186 GHYCKMIHNGIEHGMMSSIAEAWGVMRKGLSMSDDECGNEFERWNSSgELqGTFLIRIAADICRA-------TDkqgQr- 257
XP_007782629 188 GHYIKMVHNGIEHGMMCAISEAWQIMNVGLGMNYEDIGGVFDAWNKDgPLrNTFLISIGALICRThssdythEEkgkKDD 267
EKG12934     147 GHYVKMIHNGIEHGMISAVSEAYDLMKKGLGMNNDEIADVFEQWNKEgELqGTFLIWISADICRA-------KDksrNDE 219
EMD35243     195 GHYVKMVHNGIEQGILGIVNEAWELLYKCLHYSLDDISGIFAKWNEDgELrRNFLVEIGAEICGR-------HHpngPPS 267
EED21172     222 GHYVKMCHNGIEGGLLSTTCEAWDIMHKGLGMSYDEIGDVFKEWSRQgELrNNFLLDIGADICHR-------KKserGDG 294
Q0CI64       194 GHFVKMVHNGIEVGMLSTIAEAWSLLHHGLGMPYAEIANLFESWNSHgEMrNTYLLEIGVDMLRT-------KRtpqGDQ 266 Aspergillus ter...
EKG10310     194 GHYVKMVHNGIENGMLSAICEAWSFLHKSLGLSYDEIGEIFEMWNSEgELkNTYVVQIGSEICQR-------RKtpeGDK 266
XP_003034856 190 GHYVKMVHNGIEHGMLSLVCEAWGLLRKSLGLSNAEIGTILAAWNASgELrDCFLLEIGAEICQR-------QKtpeGDQ 262
2W90_A       249 -----------K--PLVDVIL-DKAGQKGTGKWTSQNALDLGVPLPIITESVFARFLSAMKDERVKASKVLaGPA---VK 311
EOA86519     254 -----------VisQVLDKVVqDVTGEEGTGVWSNTQAIDMHVPALTLNVSHGFRLASAFRGDREKANKVIdGGFp--PS 320
EGP90829     258 -----------VldTVEDKVVqDFTGEEGTGIWSNTEAVNQHIPAPTLTTAHFLRLASGDLNQRRLAQKTFgGDYp--PQ 324
XP_007782629 268 h----------VlaLVQDKVVqDVTGEEGTGIWSNTEAVTEHVPAPTLTEAHYLRLASSNRDARIKAREVMkADFd-pRP 336
EKG12934     220 y----------VldTVEDKVVqDITGEEGTGIWSNEQAVSYHIPAPTLTTAHYLRLASADRNQRIRAQETIgVEFt-pRS 288
EMD35243     268 h----------VvnEVQDKVVqDADDSEGTGIWSVMEAAKRHVSAPTIASAHFFRIASSDRAQRLQVVENLgEDIgaaRK 337
EED21172     295 kgegvdpagrpVldDVLDKVVqDDDNTEGTPLWALMESALRHVSSPTLATAHYLRIASGNRNQRVRVAKKL-DVPd-pKA 372
Q0CI64       267 kgegasekggfVldDVLDKVVqDDDGSEGTPTWSIMESANRHVSAPTLAAAYYLRLASGNRAERLSVARNL-QIPg-lKP 344 Aspergillus ter...
EKG10310     267 ngegk-gdngyIldDVLDKVVqDDDDSEGTLYWTVMDAADRHISAPTIAAGQFFRVASGNRAQRLKAEKKL-DIPk-pRK 343
XP_003034856 263 ngegk-gdfgyVldDVLDKVVqDDDGTEGTGYWTVAETALRHVAAPAVAAGHALRIASGNRAQRVKVADKL-KPPg--RT 338
2W90_A       312 --PFEGDRAHFIEAVRRALYMSKICSYAQGFAQMKAASEEYNWNLRYGDIAMIFRGGCIIRAQF-LQ-KIKEAYDR---D 384
EOA86519     321 a-LNVSDKKAFIEDVRQATYAACLASYIQGMNVIATADRVHGWEIDYSQVWQIWRAGCIIQADYiSDeILAPVLKSkpsW 399
EGP90829     325 k-VSVEDKSAFLEDLRLATYGACLAAYVQGMNIIEHADREKHFNVDYLALLQIWRAGCIIQADHiVNnLLMPIYKShstK 403
XP_007782629 337 lkLEGEEKDKFIEDLRTATYLACLCSYIQGINIIEQADKHNMWNIDYAAVLQIWAAGCIIQADYiAD-LLRPEFDDyqnQ 415
EKG12934     289 lnLSGESKQDFLEALRRATYAAFLASYIQGINIIERADRANHWNIDYSAVLQIWAAGCIIQADHiAS-LLHPILTNhraL 367
EMD35243     338 qhLDEAARTGFVENLRLAVYCACLASFAQGLNLIARASNDEGWGVDLASCLRIWREGCIIRSEYiAD-LLQPVLEQer-- 414
EED21172     373 i-DVKD-RKDFLEKLRRAVYASFLCSYCQGLELIARASADEGWGVDLGKCIQIWRAGCIIQSEAiAD-MLQPILAQdv-- 447
Q0CI64       345 ieKVKD-RKAFLEDLRRAVYCCFLASFCQGLELISRASEDEGWDIDLGQCLQIWRAGCIIRCEGiAD-LLQPCLPAdv-- 420 Aspergillus ter...
EKG10310     344 v-DVKD-KEALIETLRKAVYAAFLCSFCQGLELIARASKDEGWDINLGKCIQIWRAGCIIQEDHiAD-LLEPIFLNskqP 420
XP_003034856 339 e-TLRK-KDTFIEDLRLAVYAGFLASFTQGLQLIARASRDEEWDVSIADCLQIWRAGCIIRAGHiAD-LLQPVFVSstaP 415
2W90_A       385 paLSNLLLDSYFKDIVERYQDALREIVATAAMRGIPVPGSASALAYYDSYRTAVLPANLIQAQRDYFGAHTYER---VDK 461
EOA86519     400 e-QLNLNLSSRVAEDVKKSFPALRRVMAKSVETDQVVPALSATLEYFKVASGTELPTSFYEAELDYFGSHMFDK---RDD 475
EGP90829     404 t-EKNPLYEPAIASELKRTFAPMKRVILKAIEGDHVVPSLSATLEYLKYQTSTDLPTSMTEAQLDYFGSHMYDR---KGE 479
XP_007782629 416 k-SMNLLFNETVAKEIKEGVPSLRRVCAKGTESDHVIPALSATLEYIKFMTNTSLPTSFYEAELDFFGKHMFDI---KGE 491
EKG12934     368 d-TINLLFQPSAMSELKACVASLRDVVVKATTTDHVIPALSASLEYVKYQTSTNLPTSFSEAQLDYFGAHMYDR---KGE 443
EMD35243     415 -gVTNILTLKPVGEEIRRTLPHLRKVVGLAYEWNAHIPTLSASVEYFKYCAGKHLPSQFMEAELDYFGAHNYDL---KSE 490
EED21172     448 -qIMNIKLIDEVSRDLHDNFDALREVVLKGTESDACIPSLSASLEYLKYESNTKLPTKFMEAEMDYFGAHGYNKsgkPGE 526
Q0CI64       421 -rYTNMKFIHQVAGELHKSFSALKEIVVTGVRADHYVPAMSATLEYLKYEGSTMLPTQFMEGQMDFFGGHAYNKpgvPGE 499 Aspergillus ter...
EKG10310     421 --IMNMKLIDEVSSELKKNFSALKEITLKGIEWDNYVPAISASLEYLKYVGGGLLATQFMEAEMDFFGAHAYDRpnvrge 498
XP_003034856 416 --IFNSKLIDEVARDIRETYAPLKTVVTKGVEWDAVIPALSASLEYVKYAGNTELPTQFQEAQMDFFGAHGYDRvgvNGE 493
2W90_A       462 -------EGIFHTEW 469
EOA86519     476 sdpevkqavegkhhf 490
EGP90829     480 dqaglptEGKYHYEW 494
XP_007782629 492 agtggptEGKHHYEW 506
EKG12934     444 egtgapsEGKHHFEW 458
EMD35243     491 gag-evkKGKHHFEW 504
EED21172     527 dpgpvkkgthhyewk 541
Q0CI64       500 dpg-ptkKGAHHYEW 513 Aspergillus terreus NIH2624
EKG10310     499 dpgkpakgahhyewr 513
XP_003034856 494 dpg-ktrKGAHHYEW 507
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