3NRR,2AAZ,5H3A,3KGB,3UWL,1TIS


Conserved Protein Domain Family
Thymidylat_synt

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pfam00303: Thymidylat_synt 
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Thymidylate synthase
This is a family of proteins that are flavin-dependent thymidylate synthases.
Statistics
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PSSM-Id: 425593
Aligned: 433 rows
Threshold Bit Score: 211.5
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3NRR_B       233 FQYLDILADVLSHGVLKPN-RTGTDAYSKFGYQMRFDLS-RsFPLLTTKKVALRSIIEELLWFIKGSTNGNDLLAKNVRI 310 Babesia bovis
ESQ08890       2 KSYLELCRRVIDEGVWVENaRTGKRCLTVINADLVYDVSdRtLPVLTTKKMQWKAAIAEMLGYLRGYTSAAQFRAIGCNT 81  Desulfofustis s...
WP_004242187   2 EQYLDIAKRILEEGKWIENkRTGKRCLTIINADFTYHVDkNeFPLVTTRKAFWKAAIAEMLGYLRGYDSAAQFRAIGCNT 81  Morganella
Q07YY3         2 KQYLDLCKRIVDEGEWVNNaRTNKKCLTVINADLVYDVGnNqFPLVTTRKSFWKSAIAEILGYLRGYQNAADFRALGTKT 81  Shewanella frig...
Q87SA0         2 KQYLDLCQRIVDQGVWVENeRTGKRCLTVINADLTYDVAnNqFPLVTTRKSFWKAAVAELLGYIRGYDNAEDFRKLGTKT 81  Vibrio parahaem...
CCO61682       6 SQYEDLCKRVIDEGIWIENdRTGKRCLTVINADLEYDLTaNeFPLVTTRKAFWKSAIAEMLGYLRGYDNAADFRKLGTKT 85  Vibrio nigripul...
Q6LUM1         2 KQYLELCQRIVDDGVWIENkRTNKRCLTVVNADLTFDVAnNqFPLITTRKSFWKSAIAELLGYIRGYDNAADFRALGTKT 81  Photobacterium ...
WP_014107586   2 SQYEQLCQRIVNEGTWLTNeRTGQKCLTVINAELEYDVEnNsFPLVTTRKSFYKAAIAELLGYLRGYQSAAQFRAIGCNT 81  Glaciecola nitr...
Q5R064         2 KQYLQLCQRIVDEGVWVKNeRTGINCLTVINADLEYDVAnNqFPLITTRKSYYKSAIAELLGYLRGYNSAAQFRDIGCKT 81  Idiomarina loih...
CBN68041       2 QQFHDMLQHILDHGSRQLNaRTGEEVLFVPGYTLRFDMAdG-FPAITTKQLFFKMAKGELFGFFRGFTSAAQFREIGCTV 80  Methylibium pet...
3NRR_B       311 WElng--rrDFL--------DKNgftdreeHDLGPIYGFQWRHFGAEyldm-------------------hadyTGKG-- 359 Babesia bovis
ESQ08890      82 WNanandneEWLn-------NPFrt---geDDMGRCYGAQGRDWRNP---------------------------EGMR-- 122 Desulfofustis s...
WP_004242187  82 WNananentDWLa-------NPNrk---geDDMGRVYGVQGRQ-LKVspteaqydll--------lslndsgdkEGVKtl 142 Morganella
Q07YY3        82 WDananenqAWLd-------NPNrk---gpDDMGLIYGALGRAFPKP---------------------------DGGH-- 122 Shewanella frig...
Q87SA0        82 WDananlndAWLn-------NPYrk---geDDMGRVYGVQGRAWAKP---------------------------DGGH-- 122 Vibrio parahaem...
CCO61682      86 WDananqneAWLn-------NTHrn---geDDMGRVYGVQGRKWAKP---------------------------DGGF-- 126 Vibrio nigripul...
Q6LUM1        82 WDmnandnlAWLn-------NPHrk---geDDMGRVYGVQGRSWQKP---------------------------DGST-- 122 Photobacterium ...
WP_014107586  82 WNananenkAWLa-------NPHrk---geDDMGRVYGVQGRTWQKP---------------------------DGST-- 122 Glaciecola nitr...
Q5R064        82 WDananenqAWLn-------NPNrk---geDDMGRVYGVQGRSWQKP---------------------------DGSH-- 122 Idiomarina loih...
CBN68041      81 WNdnanktkAWlanpyrqgeDDL-------GRFGYLQWTDWRDWREAttpaqrdemlaqgyevrahdaergvwiLRRS-- 151 Methylibium pet...
3NRR_B       360 --------IDQLAEIINRIKTNPNDRRLIVCSWNVSDLKK-MALPPCHCFFQFYVsd--nKLSCMMHQRSCDLGLGVPFN 428 Babesia bovis
ESQ08890     123 --------IDQLRNVYDDLRQGIDNRCEIMTFMNPGER-DrACLNACMHTHTFSIle--drLYLTSYQRSDDLPLGHGFN 191 Desulfofustis s...
WP_004242187 143 inelrkntFDQLRKVYDNLKKGIDDRGEIISFWNPGEF-NqGCLRPCMFMHHFSVld--gtLYLNSYQRSCDYALGYVFN 219 Morganella
Q07YY3       123 --------VDLLQQIVDDLSNGIDNRGEILTFYHPGAF-DlGCLRPCMYEHHFSLlg--dtLYLNSTQRSCDVPLGLNFN 191 Shewanella frig...
Q87SA0       123 --------IDQLRKIVDDLTRGVDDRGEILNFYNPGEF-HmGCLRPCMYSHHFSLld--dtLYLNSTQRSCDVPLGLNFN 191 Vibrio parahaem...
CCO61682     127 --------VDQYKKIIDHLSKGIDDRGEILNFYNPGEF-HmGCLRPCMYSHHFSLlg--dsLYLNSTQRSCDVPLGLVFN 195 Vibrio nigripul...
Q6LUM1       123 --------IDQLRKIVDNLSEGIDDRGEILTFYNPGEF-DlGCLRPCMHTHTFSLlg--dtLHLTSYQRSCDVPLGLNFN 191 Photobacterium ...
WP_014107586 123 --------LDQLAKVIDNLSQGIDDRGEIITFYNPGEF-DmACLRPCMHTHTFSLlg--kdLYLTSYQRSCDVPLGLNFN 191 Glaciecola nitr...
Q5R064       123 --------LDQLKKVINNLSKGIDDRGEIVTFYNPGEF-ElGCLRPCMHTHNFSLlg--dtLYLTSYQRSCDVPLGLNFN 191 Idiomarina loih...
CBN68041     152 --------INQLETSLHAVMTNPSDRGIILSGWNPAEIDQ-GALRSCHVSYMLQVdvatgTLHLTLWQRSFDAPLA--YN 220 Methylibium pet...
3NRR_B       429 IASYSILTAMVAQVCGLGLGEFVHNLADAHIYVDHVDAV-TTQIARIPHPFPRLRLn--PDirN---------IEDFT-- 494 Babesia bovis
ESQ08890     192 QVQVGWLLMVMAKITGLRAATAYHKIVNVHIYEDQVELMrDVQLIRAPFPLPKLVInpaIK--T---------LEDLEtw 260 Desulfofustis s...
WP_004242187 220 APQCYFLLAIMAQITGLKCGKVYHKVVNLHLYEDQLELMrDVQIARKPFASPKLHInpdIK--T---------LDDLMtw 288 Morganella
Q07YY3       192 MVQVYVLLALMAQITGHKPGKAYHKIVNAHIYEDQLEPMrDVQLAREPFASPKLIInpkIK--T---------LKDIEtw 260 Shewanella frig...
Q87SA0       192 MVQVYVFLAIMAQITGKKPGQAFHKIVNAHIYEDQLELMrDVQLKREPLQAPTFHInpeIK--S---------LEDLEtw 260 Vibrio parahaem...
CCO61682     196 QIQVAWLLQITAQITGLKAGKAFHKIVNAHIYEDQVELMkD-QIKREPYAAPKLIInpeIK--S---------LEDLEtw 263 Vibrio nigripul...
Q6LUM1       192 QVQVYTLLALVAQITGKKPGLAYHKIINAHIYEDQLSLLrDVQLTRTPFAAPKLIInpkIK--C---------LEDLEtw 260 Photobacterium ...
WP_014107586 192 QIQVYVMLALVAQITGNRPKKAYHKIINAHIYENQFDLMkDVQLSRTPFDNPTLTInpkIT--S---------LNDIEtw 260 Glaciecola nitr...
Q5R064       192 QIQCFALLALVAQITGHKPGKAYHKIVNAHIYENQLELMrDVQLKREPFPSPQLHInpeIK--S---------LEDIEtw 260 Idiomarina loih...
CBN68041     221 VAIGAMYLEIMARLAGLKAGTFTHFISDAHIYAKHIPGV-KEMLAREHFPQPTLDLgniPT--LtsaaeipgiFATLD-- 295 Methylibium pet...
3NRR_B       495 --IDDIVVEDYVSHPPIPMAMS 514 Babesia bovis
ESQ08890     261 vtPDDFELEGYRHHPGINYPFS 282 Desulfofustis sp. PB-SRB1
WP_004242187 289 vtTDDFTVTDYQHHDPIKYPFS 310 Morganella
Q07YY3       261 vtLDDFSVEDYQHHDAIKYPFA 282 Shewanella frigidimarina NCIMB 400
Q87SA0       261 vtLDDFWVEGYEHHDPIRYPFS 282 Vibrio parahaemolyticus RIMD 2210633
CCO61682     264 vtVDDFEVVGYQHHEPIKYPFS 285 Vibrio nigripulchritudo
Q6LUM1       261 vtMDDFDVIGYEHHEAIKYPFS 282 Photobacterium profundum SS9
WP_014107586 261 vtTDDFTVHGYEHHDAIAYPFS 282 Glaciecola nitratireducens
Q5R064       261 vsKDDFIVSGYQCHDPIKYPFA 282 Idiomarina loihiensis L2TR
CBN68041     296 --PNQVKLVNYQHHPKIAFEMt 315 Methylibium petroleiphilum PM1
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