3MSU,1IXE,1AJ8,2R9E,6ABV,1VGM,1O7X,2IBP,6ABY,2P2W,3HWK,3TQG,2C6X


Conserved Protein Domain Family
Citrate_synt

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pfam00285: Citrate_synt 
Citrate synthase, C-terminal domain
This is the long, C-terminal part of the enzyme.
Statistics
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PSSM-Id: 459747
Aligned: 719 rows
Threshold Bit Score: 94.8803
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3MSU_B         54 GFMSTAACESKITYIDgg----kGV--LLHRGYPIEEwT-------QKSN-YRTlCYALIY-GE---LPTDEQVKSFRQE 115 Francisella tu...
XP_966082      61 SL----FLETEIFFE---------HkdIFYRGINIVDlC-------SYGN-FEEtIYLFLY-KK---LPNIKELKEKRNI 115
CAQ40987       46 HPQPCVMLETEIFLD---------FkgHFYRGMDVRDlC-------RRAT-FDEvIFFFLH-KR---WPNESELKRKNCY 104
WP_013182309   20 GMRGYPVGYCTTSSVD-------PEkgLFYVGRPVSElS--------KNT-PEEvIYLLYH-GK---EGSQQELSAFKEE 79  Waddlia chondr...
Q6MAA4         16 GLRGYPVGYCTTSSVD-------PVkgLFYAGHPVSEiD--------QWE-PEQvIYLLYH-GY---VGKPEEVSRFSQD 75  Candidatus Pro...
WP_006340267   16 GLRGYPVGYCTTSNVD-------PIkgLFYRNYPVADiA--------YWE-PERaIHLLYT-GN---DGSKGEIEDFSNL 75  Parachlamydia ...
CCB88579       16 GMRGYPVGYCTTSYVD-------PIkgLFYRGRPISElY--------KWE-PERvIYLLHH-GK---EGSAQDISQFSQE 75 
jgi:Hoch_4737  44 GLRGLPTLITNVSTVc-------RErgLIFRGRELPSlT--------GAS-VLE----LLWmGItakAPTSAELDELARE 103
EFN84182       58 GLn-----------------------gIVYRGLTISEvMtllprrgGSPS-AEAvFWLLLT-GD---VPTHRQTASLIAD 109
EFN70192       17 TLW--DKGKSCITPNErktnfgmRKrhILYRGLTIPEvItll-prqGNSPsAEAiFWLLLT-GD---IPTQQQTTSLIAD 89 
3MSU_B        116 IIN--Km-PV---------CEHVkAAIA-AMPq-HTHPMSSLIAGVNVLAAEHIHn---------------GQKES---- 162 Francisella tu...
XP_966082     116 FIN--AlnLL---------DEKRiFEMYnNVS--HCNILELLRNYFIHSSQDK-------------------KKISdint 163
CAQ40987      105 VQNelNr-FC---------ERNVlEMGR-LLQ--TSDPLQLIRIALLKFSHQSEQq---------------TETEGep-k 155
WP_013182309   80 LCK--Rs-II---------SDQLiESIR-ALPrqA-HPMQLLVCALSLTTSFE-------------------GAGD---- 122 Waddlia chondr...
Q6MAA4         76 LLI--Ra-NC---------STALiESIE-KLPrnI-HPMKLFSIALLLASGFE-------------------GKND---- 118 Candidatus Pro...
WP_006340267   76 LQR--Ha-IC---------APRViDHIR-KLPneG-HPMQLFCAALFTCGMIE-------------------GQND---- 118 Parachlamydia ...
CCB88579       76 LKK--Ra-HC---------SQAVaKHIE-SLPrqG-HPMKLFCSALLILGMLE-------------------GLKD---- 118
jgi:Hoch_4737 104 FGQ--H--AL---------PEQTlAILDaFGPk--lDPILAFSHCYSHLAASLEGedtf--------raghGDQAF---- 156
EFN84182      110 WTS--Rr-EKhaewwsglrGETVlSVLR-SLPe-TITPLGKLSVALTIFNVSKCAkeakrhgvmpytywecQLTHHll-f 183
EFN70192       90 WTS--RrqKYteww-sgprGETIvSILR-SMPe-AITPMHRLSIALTIFNISKQAkea----------krhGAIPYt--- 151
3MSU_B        163 QDEVAKN----IVAK-IATIAAMAYRHNHGkkf---lePKm---eYGYAENFLY-------------------------- 205 Francisella tu...
XP_966082     164 CYYEILAsylkLI---NPKYSLENYKNVFLdhk---iyTN------DFVSSCLLfnfyiksnclkekikkekndkivmnn 231
CAQ40987      156 STHDPLFnylkILAA-SVKLLLRWGHSELVsp-----pMNd---yADFTSFLIDayptegkevnfhnkgkee------dd 220
WP_013182309  123 WKEDGLN----LVAK-IPVIVAHLINHHAGwgecnpskPE-----MGYMENFTQ-------------------------- 166 Waddlia chondr...
Q6MAA4        119 YHEDYLN----LIAK-VPEIAATVINHHAGwgktkqsqPQ-----LGYMENFTQ-------------------------- 162 Candidatus Pro...
WP_006340267  119 YRADCLA----LIAK-IPEIAAAVINYHAGwgeskpskPE-----LGYIENFVH-------------------------- 162 Parachlamydia ...
CCB88579      119 YKEDCLN----LIAK-LPHLTAIVINHHAGwgptpapnGE-----MGYMENFAH-------------------------- 162
jgi:Hoch_4737 157 AAARALGhvkrIVALsLPLIGAIYSRLRGrp------qQRpidwsLGWGSNLCR-------------------------- 204
EFN84182      184 GFEYTYEdsmeFLAM-LPAIIGLIAKGQVStn----vsSD-----SDWMQFLLE-------------------------- 227
EFN70192      152 YWEYTYEdgmeFLAI-LPAIIGLIAKRKIlt------nVSs---kGDWVQFLLE-------------------------- 195
3MSU_B        206 ----------------MMfAddesYKpd-eLHIKAMDTIFMLHADHEQ-NASTSTVRLSGSTGNSPYAAIIAGITALWGP 267 Francisella tu...
XP_966082     232 iynydhinnhieskdvICkVp--qVNyd-mYSIKLISNVLIILCDNNI-NESTFLIRMI-SNMCTNYFNICISMVTFYID 306
CAQ40987      221 aenlnasresneskgqTLtP-----HpwreERIKLLNAFLVCMCEQGI-NENTFFVRMLSSVQCHNYFSLCVSASTFYID 294
WP_013182309  167 ----------------MLnv----pNadlkQLTEVMRLFNVLHYDHGGgNLSAFIGKGIASGLQDMYGSLAGAMSALAGP 226 Waddlia chondr...
Q6MAA4        163 ----------------MLnv----pDanqqELARAFKFFNVLHYDHGGgNLSAFVGKAVASGLEDLYGSMSAAMCALAGP 222 Candidatus Pro...
WP_006340267  163 ----------------MLnv----pNaspeELIEVFKLFNVLHLDHGGgNLSTFVGKAVASGLQDMYGSIAAAMSALAGP 222 Parachlamydia ...
CCB88579      163 ----------------MLqv----pKakkdELSEVFRLFNILHYDHGGgNLSTFVGKAVASGLEDMYGSIASAMCALAGP 222
jgi:Hoch_4737 205 ----------------AL-------DldeqRFARILEIHGIVHLDQGKgNPSSHVSHVVATTGADPYRCVAASLIALSCP 261
EFN84182      228 ----------------CLsNvienLDsrksSVADFLRLYVTLNADDDGgTPAAHITHILGSTDLNINEVLASSALAYTDE 291
EFN70192      196 ----------------CLtNmnenFDsrksSVADFFRLYITLNADDDGgAPPAHITHILGSTDLHINEILSSSVLAYVDE 259
3MSU_B        268 A-HG-GANEAVLKMLS----EIgSTE--------NIDKYIAKA--KDkddpFRLM-GFGHRVY----------------- 313 Francisella tu...
XP_966082     307 IfKEiNLHTSLQYFLNf---KMfQNKk-------ENKDIINDNieE-----NQLN-FFFLKNN----------------- 353
CAQ40987      295 AfRNvDLRDSLEGFLR----FV-VPSv------gTIKRGEHNKfhK-----NREPeG-GHLRQgnhlddeiathlnvdff 357
WP_013182309  227 R-HG-KANQDCLEFVKdvlgNLgENAta-----gQVEQLIRDRlaNN----QLIY-GFGHAVL----------------- 277 Waddlia chondr...
Q6MAA4        223 R-HG-KANQDCLTFVHqlveELgEHSte-----eELERLIRAHldKG----ELIF-GFGHAVL----------------- 273 Candidatus Pro...
WP_006340267  223 R-HG-RANQDCLEFVEeiqgELqNDVsp-----eTVEALIRDRlaNN----QLVF-GFGHAVL----------------- 273 Parachlamydia ...
CCB88579      223 R-HG-KANQDCLQFVQlvldEVgEGAsa-----nQVENLIRKRlqNN----ELVY-GFGHAVL----------------- 273
jgi:Hoch_4737 262 S-HA-FAGIGVLDTID----ELhrlhg--pptreQVRDYLITRlrCG----ERVY-GIGQAVM----------------- 311
EFN84182      292 P-AT-GTMLQWEELQT----KI-RSTlgqawtehSLIDRVLHVydK-----DKLI-G--HKEA----------------- 339
EFN70192      260 P-KS-GTMLQWKELQT----KV-QNTlgqawtehGLRSRVLNLwsR-----DKLI-G--HQEA----------------- 307
3MSU_B        314 --KNTDPRAT--AMKKNCEEILAKlgHSDNPLLTVAKKLEEIALQDEFfiE--RKLF--SNVDFYSGIILKAM-GIPEd- 383 Francisella tu...
XP_966082     354 ---NFNKKNN--ILKKIITDYCKV---TSQHNINILNHFIQVENYFLK--H--KNKY--PSLYYYTLLLFHIL-NIPLy- 417
CAQ40987      358 fhKGNSYREKnaILKEHLTEYCNN---TCEKNLHCLKHFEQVEEFFLKnqK--K--H--ASCYYYPLLTFHLL-GVPLp- 426
WP_013182309  278 --RVEDPRAS--VFYEVAKKLFP-----DHPLVKIAKLLRTEGTKVLKenPkiSNPY--PNVDAISGTVLTAA-GFPYpe 345 Waddlia chondr...
Q6MAA4        274 --RVEDPRAT--LLYEVTNQYYA-----SHALVKMAQLLRKVGSKVLQnnPkiSDPY--PNVDAISGILLTAA-GFPCse 341 Candidatus Pro...
WP_006340267  274 --RVEDPRAT--VLYALAEKKYP-----DNPLVKLTQILRTIGPKVLAenPkiSNPY--PNVDAISGTVLSAA-GFPYpe 341 Parachlamydia ...
CCB88579      274 --RAEDARAA--IFYDIAEEKFK-----DHPLVKIAFLLRSEGPKVLKenPkiSDPY--PNVDAVSGTVLTAA-GFGYpe 341
jgi:Hoch_4737 312 --KNLDTRFA--CLHQAA---APLl-AGDP-YYQTMAHMVDVMGEAFAavGk-HEVVphPNVNMVSSLILCRLmGVDRa- 380
EFN84182      340 --KRCDPRYT--ALSNYAKQY--------LPNNSEIKDITQILRSTMKrsNg-KDIC--PEQSAIAAPIFHSL-GLKD-- 401
EFN70192      308 --DFCDPRYT--ALLDYA---------------------RQHLPD-----------N--PEIKCY---GLKDM-NFNQ-- 343
3MSU_B        384 M--FTAIFALARTSGWISQWIEmvn-dpaQK---IGRPR 416 Francisella tularensis
XP_966082     418 Y--YPSFYFISRLLSFTAHINEqk---enNK---IIKYA 448
CAQ40987      427 L--LPSVFFIMRLLSFMAHRQEqi---tnNK---LVKYA 457
WP_013182309  346 Y--YTVLFGLSRVVGISRQLIYerveargGKgtpIIRPK 382 Waddlia chondrophila
Q6MAA4        342 Y--YTVLFGLARVVGIGRQIVYerkeareGKgtpIVRPK 378 Candidatus Protochlamydia amoebophila UWE25
WP_006340267  342 Y--FTILFGLARTVGIAVQIVHerciareGKglpIVRPK 378 Parachlamydia acanthamoebae
CCB88579      342 Y--FTVLFGLARCLGISIQIVYerceargGKgtpIIRPR 378
jgi:Hoch_4737 381 M--LPLLFAASRIIGNLCQYIEnli--lpGR---VCRPL 412
EFN84182      402 MrfNQTILYMARTLGAIASIIWska--vnTP---VEYPV 435
EFN70192      344 -----TILYMARTLGMIASIIWtka--vnAP---VEHPI 372
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