2O7D,2NYF,6V6H


Conserved Protein Domain Family
Lyase_aromatic

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pfam00221: Lyase_aromatic 
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Aromatic amino acid lyase
This family includes proteins with phenylalanine ammonia-lyase, EC:4.3.1.24, histidine ammonia-lyase, EC:4.3.1.3, and tyrosine aminomutase, EC:5.4.3.6, activities.
Statistics
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PSSM-Id: 425535
Aligned: 419 rows
Threshold Bit Score: 230.003
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2O7D_E              17 IDLDQAHAVASg-Ga-RIVLAPParDRCRASEARLGAV-IR-EA--RH-VYGLTTGFGPLANRLIs---gENVRTLQA-N 85  Cereibact...
CAM04113            14 LRCADVVRVAR--RsaSVKLNQDavRRAESTYRLALDIgAK-RS-----VYGRTTGVGANRHAVVd---aDTADEHGL-R 81  Saccharop...
ABS02777            20 LGLDDLTDLALgr--aHAVVDRDvlGRLGVLHEAMGAA-RE-RG--A--VYGATTGVGANKDVEVddeqhEHPQAHGL-R 90  Kineococc...
WP_023361664        13 LTPEGLTAIASgh--aGIAVDPAalRLVEARHAVMRDA-RE-RG--T--VYGANTGVGANRHETAg---tPDVVDHGL-R 80  Actinopla...
AMEG_HIPS:KALB_202  10 LTGQDVVAIAVg-Rv-PVSVDALarERVRQAAALAQDV----SG--QRqVYGRTTGVGANRVIGVd---qQDVPAFGR-R 77  Kutzneria...
Q82HK4              31 IGVSDVVCLADg-AsrPV-PGTEamKRVEESWDAARQI-AA-TG--R--VYGRSTGVGANRNEDVp---tEAAAGHGL-R 98  Streptomy...
BGI:SBI_04541       26 LRVADVVRLADr-TgrPAAPDPAalARAERAWETANRL-AA-TG--R--VYGRSTGVGANRTEDVg----AADQDHGL-R 93  Streptomy...
WP_014845926        31 LTWRDLASALKaeRv-EVELDPVsrGQMLRAREAGLEI-LEsNPgmRA--YGWNQALGPFKDRRLe---pEEQLRFQV-N 102 Pseudopro...
WP_013266491         9 LTVEDICNVAVn---sPVSMCQEslQLLSRSRKAYEAG-AS-LG---K-VYGYSTGLGALASAE------EGTWRGREaQ 73  Acidilobu...
jgi:Vdis_2488       11 LTLTEIIGVSRn-Ye-EVRVGSDalVAVERSRRILEEL-IH-GN--VR-IYGVNTGLGDLYNVTVn---pEDVAKYSL-E 79  Vulcanisa...
2O7D_E              86 LVHHLASGVGPVLDWTTARAMVLARLVSIAQG-----ASGASEGTIARLIDLLNSELAPAVPSRGTVGX--DLTPLAHMV 158 Cereibact...
CAM04113            82 LLRSHAGGTGEPLPDAIVRSTLVIRLNQLAAA-----GSGVHPRLLHALETALRVGALPLVHSRGAIGTg-DLSALAEIG 155 Saccharop...
ABS02777            91 LLRSHAASLGPVEDEATTRAALVVRLNQLLAGahaglGAGISPPVLRALAEAVESGALPTLHRFGGIGTs-DLAPLAELG 169 Kineococc...
WP_023361664        81 LLRSHCAGSGPVEDNSTARAAMAVRLNQILAG-----GSGISLRVTEALVAALRSGAVPALHRWGAIGTa-DLAALAELG 154 Actinopla...
AMEG_HIPS:KALB_202  78 LLRSHAGGTGPLITEPEARAMMVIRANQLLAG-----HSGVSEHVVDALALALNAGCYPQVHSVGAIGTg-DLTALAELA 151 Kutzneria...
Q82HK4              99 LLRSHAGAIGAELPARQVRAMLAVRVNQLLAG-----GAGLRPTVVTALCEALENGAYPVVNEFGSVGTg-DIAALAQVG 172 Streptomy...
BGI:SBI_04541       94 LLRSHAGAIGAPLPAREVRAMLAVRANQLLAG-----GAGLRPAVVTALVEALARGAHPIVNEHGAVGTg-DLAALAQTG 167 Streptomy...
WP_014845926       103 VLRSHSTGLGEELPRRVSRLALIIRANCLARG-----TSGARPELVERMNDAVNLGLVPVMPGTGSMGTg-DLQPMAAAG 176 Pseudopro...
WP_013266491        74 VLREHDLGIGPEAPREVVRAAMLVRASQLAQG-----FAPVRPEVAQRLVDSLNYDIVPAVSLEGSVGAsgDLAPLARIS 148 Acidilobu...
jgi:Vdis_2488       80 MLIDHSTGVGDYAPDDWVRATMLIRAHQLSLG-----YSGIRGIVVERLIDFLNMKITPLIPRYGSVGAsgDLAPLAHMA 154 Vulcanisa...
2O7D_E             159 LCLQ-G--RGD--------------------------FLDRdGTRLDGAEGLRRGRLQPL-DLSHRDALALVNGTSAMTG 208 Cereibact...
CAM04113           156 LTIA-G--QRP----------------------------------------WHVGSLDPV-PISPGDALAFISSNAATLA 191 Saccharop...
ABS02777           170 LTLV-G--ERP----------------------------------------WRRGAVAPV-PLGAADALPLISSHALTLA 205 Kineococc...
WP_023361664       155 LTLA-G--ERP-----------------------------------------WRSGAGPVtTIDATDALPMISSSALTVA 190 Actinopla...
AMEG_HIPS:KALB_202 152 LTLV-G--ELP----------------------------------WAGPHPLP-----PI-ELATSDALAFLSSNALTIG 188 Kutzneria...
Q82HK4             173 LALA-G--EHPwrraetsgglgsetsggpgagasggrYAGGvRALRRGASAREIGAPEPQ-LLDNNDALALISSNALTLG 248 Streptomy...
BGI:SBI_04541      168 LALV-G--EHPwdlad---------------------------------aapggGAPAPI-ELDSNDALALISSNALTLG 210 Streptomy...
WP_014845926       177 LALT-GdvAGR--------------------------VRGDdGEERCAPQAWAAMGRDVEfQLAPGEAIALISGSAVLTA 229 Pseudopro...
WP_013266491       149 RCIYsG--EGQ--------------------------ATVR-GRRLSCGEALEAAGLKPL-ELGPGEALAIINSNAFSVA 198 Acidilobu...
jgi:Vdis_2488      155 LTLL-G--KGF--------------------------VKYQ-GKAMPSAEALKLAGLEEL-RLSYKEALSLINGTSYSAA 203 Vulcanisa...
2O7D_E             209 IALVNAHACRHLGNWAVALTALLAECLRGRTEAWAAALSDLRPHPGQKDAAARLRARVDGSARVvrhviaerrldagdiG 288 Cereibact...
CAM04113           192 ESVLAWHDLRRLLHASHVIAALSFCALGGSPEAFSEQVHGARPHPGSVRCAAEMRRILgld----------------vdP 255 Saccharop...
ABS02777           206 TASLALCRLRQLLLAGTGISALSFLALRGNPQAWAPPVHAARAHPAQTGLAATLHALVAG-------------------G 266 Kineococc...
WP_023361664       191 TAALALTEVHQQLRASTVVAALSFLALRGNPEAYDAVVHAGRTHPSQSEVAALLRELVAG-------------------C 251 Actinopla...
AMEG_HIPS:KALB_202 189 QATLAQARISALLDQTCTTAALSLLAVDGSVEPFAEVVHQARPHRGSGQVAQRVRTLLGEi------------------R 250 Kutzneria...
Q82HK4             249 QSALALHELRGLIGATQVVAALSLLAVDGSHEAYAAPVHTARPHRGSAEVARIMRELIGAADRPt-------------pP 315 Streptomy...
BGI:SBI_04541      211 QSALALAELRRLLAASLTVAALSLIAVGGSLEAYAQPVHEARPHPGSVEAAARMRALLGAPARPt-------------pP 277 Streptomy...
WP_014845926       230 HLALAVEEVYRQVETLLGAFALFCEAARVERNAFDPRIHAERHMPWEMQANDLILRLIGDSQWTtneg-------rrraG 302 Pseudopro...
WP_013266491       199 MASLGVCASLRLLGESLNVMSETLEVTGCNPQHFSTAVANSKRLEGVKDVVASLKVDC---------------------- 256 Acidilobu...
jgi:Vdis_2488      204 VASLGIWDSYKLLRAAVAVMALVIEASRASIAPLSVEANATKLHRGEAEIARVMSELLNDSKNV---------------N 268 Vulcanisa...
2O7D_E             289 TePEaGQDAYSLRCAPQVLGAGFDTLAWHDRVLTIELNAVTDNPVFppd-----gsVpaLHGGNFMGQHVALTSDALATA 363 Cereibact...
CAM04113           256 PeGRrLQDPFGLRAFPQVHGPALDAADALERVLSIDLNAAAENPLIhvd----serV--YHHGQFSTAYLALSLDSLRAA 329 Saccharop...
ABS02777           267 PePArLQDPFALRTAPQVLAPAFTAAQALEDVLALEASTPGENPLVsp------egV--FHHGQFHAASLATALDTLRAT 338 Kineococc...
WP_023361664       252 StPArIQDPFGLRVVPQVTAPALHAVHELRRVLTTELNAAAENPLVtt------egV--RHHGQFHTATLSAGLDAVRGA 323 Actinopla...
AMEG_HIPS:KALB_202 251 HvPArVQDPFGLRCFPQVHGEAVDAVAALDEVLAVELNAGAENPLVsvv----dgdV--FHHGGFHSITLSLALDRARLA 324 Kutzneria...
Q82HK4             316 L--GrIQDPYGFRCLPQIHGPAHEAADALEAVLAVEINAAAENPLIspg----dlaA--YHHGGFYQAQLALALDHFRLA 387 Streptomy...
BGI:SBI_04541      278 L--GrIQDPYGFRCLPQIHGPAEDAADALERVLTVEFNAAAENPLIcpd----deaA--YHHGNFYAAHTALALDHFRLA 349 Streptomy...
WP_014845926       303 EtAPrIQDSTSIRSVPHQIGIILRELERAREDVTREANSSTCNPLLipnytgegheF--LSGGNWDATVLGHAAQSVNSC 380 Pseudopro...
WP_013266491       257 QrSPrLQDPYCIRCVPQVYGSALEVLRFAAKLLEAEAYSSSDNPFVyn------dsV--YHACNFHASAAGMASDMAKVA 328 Acidilobu...
jgi:Vdis_2488      269 TsGR-VQDPYSIRCMPQVLGSVLDSLTWALRNVLNEVNSVSDNPIIin------nsV--YSTCHFHGQYIALSTDLLNTS 339 Vulcanisa...
2O7D_E             364 VTVLAGLAERQIARLTDERL-NRGLPPFLHrGPAGLNSGFMGAQVTATALLAEMRA-TGPASIHSISTNAANQDVVSLGT 441 Cereibact...
CAM04113           330 LHHVAELSAARLSDLVEPELtG--LTPFLSsGPPG-SSGIMILEYVAHDALGQLRHaAAPVTLGTAVISRGLEDHASFST 406 Saccharop...
ABS02777           339 TFGVLTLSAARLALLLRPEHtG--LRAFLAaGPRG-SSGLMIGEYVVQDVLAELRPaTAPSTSGTVSISLGLEEHASFAT 415 Kineococc...
WP_023361664       324 YFPALSLSVARLGLLMRPDLtG--LRAFLAaGPAG-SSGLMISEYVVQDVLAEIRViVPPVLPGTLSISLGLEEHASFAT 400 Actinopla...
AMEG_HIPS:KALB_202 325 VLQTAQLSAGRLAMLCEPAYtG--LRPFAAdEPTG-SSGLMVIEYTAAASLASVRSmAMPAVLGHATLSRGVEEHASFSA 401 Kutzneria...
Q82HK4             388 ITQVARLSTSRLSTLNEPAYtR--LRPFLAdHEPA-SSGVMILEYAAGAALGDLRAfSAPASLGHAVLSRGVEEQASFAS 464 Streptomy...
BGI:SBI_04541      350 ALQTARLSTARLAALSEPEFtR--LRPFLGdTAPA-SSGVMILEYAAGAALGEMRAvSHPASLGHAVLSRGVEEQASFAS 426 Streptomy...
WP_014845926       381 LARLAVLTKDLAARLLHDGW-SHGLPAGLSgGEVGINSGMLLLHTSAAALIPEIQLlANPVGALSFPLKGGQEDFHTMAM 459 Pseudopro...
WP_013266491       329 LAHVGNMIERRTAHLLSSATtG--LPDFLAv--KGTVVGAMIYQYTAASLAAKLRQlASPGSVHSIPTSGLQEDVVSMAP 404 Acidilobu...
jgi:Vdis_2488      340 LAVLGNLIERQVAQLLRREInG--VSNYL--ANGPWRVGLMLTQYTAAALSARLRElSTPSTVQNIPTSGFQEDVNSMSA 415 Vulcanisa...
2O7D_E             442 IAARLCREKIDRWAEILAILALCLAQAAELrCgsgld-gvspAGKKLVQALRE 493 Cereibacter sphaeroides
CAM04113           407 QAARSTSAAISAYRTVLACELLGAVRALRLagte----lpdaPIGQAFARASR 455 Saccharopolyspora erythraea NRRL 2338
ABS02777           416 QGARALRQTAELAPVVLAVEALAAVRALRAaPdrm-----spGAAALFAVFDE 463 Kineococcus radiotolerans SRS30216 =...
WP_023361664       401 QGARSLRTMAGLAPVLLAAELVAAVRALRMvPerl----tggTARRAFEIAAE 449 Actinoplanes friuliensis
AMEG_HIPS:KALB_202 402 QSARMTGEVVPHYVIVLACELIAAVRVLRMrGlr------peGSQDLVAAFDN 448 Kutzneria albida DSM 43870
Q82HK4             465 LAARQTLRACDAYRLVVGCELVAAVRALRQrDlrpd---pelPVGRALELAES 514 Streptomyces avermitilis
BGI:SBI_04541      427 LAARQTLRVVDNYRQVLGCELVAAIRALRQrGlepd---pelPVGAAYALAEK 476 Streptomyces bingchenggensis BCW-1
WP_014845926       460 AAVNGLRANSRRFDQLLAVLFVISGQGIHLlEermrglplgtGSALIHEQLRT 512 Pseudopropionibacterium propionicum
WP_013266491       405 NSSYELLRSTAVLARLIAVEDALASQASKVaRglpl--------ddpkDALER 449 Acidilobus saccharovorans
jgi:Vdis_2488      416 NSAIKLHEINSLVAQLIAILAYDTYMVASTnNacrn---cgrMTTRIYDVINK 465 Vulcanisaeta distributa DSM 14429
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