This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:22.214.171.124. Succinate-semialdehyde dehydrogenase EC:126.96.36.199. Lactaldehyde dehydrogenase EC:188.8.131.52. Benzaldehyde dehydrogenase EC:184.108.40.206. Methylmalonate-semialdehyde dehydrogenase EC:220.127.116.11. Glyceraldehyde-3-phosphate dehydrogenase EC:18.104.22.168. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 22.214.171.124. Acetaldehyde dehydrogenase EC:126.96.36.199. Glutamate-5-semialdehyde dehydrogenase EC:188.8.131.52. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.