3HHD,4NA2,5E6K,2GP6,6P9M,1E5M,4B7V,2GFV,1TQY


Conserved Protein Domain Family
ketoacyl-synt
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pfam00109: ketoacyl-synt 
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Beta-ketoacyl synthase, N-terminal domain
The structure of beta-ketoacyl synthase is similar to that of the thiolase family (pfam00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains. The N-terminal domain contains most of the structures involved in dimer formation and also the active site cysteine.
Links
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Statistics
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PSSM-Id: 425468
Aligned: 77 rows
Threshold Bit Score: 91.5426
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3HHD_C         4 EEVVIAGMSGKLPESENLQEFWDNLIGGVDMVT-----DDDRRWKAGLY---GLPRRSGKLKDL------SRFDASFFGV 69   human
P39525         3 RRVVITGLGCVTPLGRSLSESWGNLLSSKNGLTpitslPNYN-EDYKLReksIPSTITVGKIPEnfqnenSAINKLLFTS 81   Saccharomyces ...
O25284         2 RRIVVTGMGMINSLGLNKEDSFLAIAKGECGIKh---iES--FDASAF------PVRIAGEITD--------FDPTEVM- 61   Helicobacter p...
Q9I3B2         2 RRVVITGLGIVSCLGNDKDTVSANLRAGRPGIRf---nP-----SYAEM---GLRSHVSGSVDL-------NLEELIDRK 63   Pseudomonas ae...
P52410        61 KRVVITGMGLVSVFGNDVDAYYEKLLSGESGISlidrfD-----ASKF------PTRFGGQIRG------FSSEGYIDGK 123  thale cress
XP_002276214 144 RRVVVTGMGVMSPIGHEPDSFYNNLLEGVSGISe---iES--FDCSHF------PTRIAGEIKS------FSTDGWIAPK 206  wine grape
P23155         4 RRVAVTGIGVVAPGGIGTPQFWRLLSEGRTATRrislfD-----PSGL------RSQIAAECDFep------sDHGLGLA 66   Streptomyces c...
1TQY_G         3 RRVVITGVGVRAPGGNGTRQFWELLTSGRTATRrisffD-----PSPY------RSQVAAE---------ADFDPVAEGF 62   Streptomyces c...
P40804         7 PEVVVTGVGVTASIGQGKEDFASSLLSGRHAFDv---mK-----RSGRQ---KDSRFIGAEIAS------LSYPDRLSKK 69   Bacillus subti...
CCA59267       3 aSVVVTGLGVAAPNGLGREDFWASTLGGKSGIGr---lT--RFDPTGY------PARLAGEVPG------FAAEEHLPSR 65   Streptomyces v...

3HHD_C        70 HPKQAHTMDPQLRLLLEVTYEAIVDGGINPds---lrGTH-----TGVWVGVSGS----ETs------eALSRDPEt--- 128  human
P39525        82 QDER--RTSSFIKLALRTTYEALHNAGLLNpnditinTSLcnldhFGCLIGSGIGs---IQdiy---qtSLQFHNDn--- 150  Saccharomyces ...
O25284        62 NPKDVKKAGRFIQLALKATREAMKDSGILDahnr--cpeEla-nrMGVSSGSGIGg--lGNiea--nsiFCFEKGp---- 130  Helicobacter p...
Q9I3B2        64 VFR---FMGDAAAYAYLAMEQAIKDSGLTPeq---isNPR-----TGLIAGSGGA----STlnqmeaidTLREKGVk--- 125  Pseudomonas ae...
P52410       124 NER---RLDDCLKYCIVAGKKALESANLGGdklntidKRK-----AGVLVGTGMGg---LTvfse-gvqNLIEKGh---- 187  thale cress
XP_002276214 207 LSK---RMDKFMLYMLTAGKKALADGGITEdv---tdELDks--rCGVLIGSAMGgikvFNda----ieALR--Vsy--- 269  wine grape
P23155        67 TAQ---RCDRYVQFALVAASEAVRDANLDMn-----rEDPw---rAGATLGTAVGg---TTrleh-dyvLVSERGSrwdv 131  Streptomyces c...
1TQY_G        63 GPRELDRMDRASQFAVACAREAFAASGLDPdt---ldPAR-----VGVSLGSAVAa---ATsler-eylLLSDSGRdwev 130  Streptomyces c...
P40804        70 MLR---KASFSSRAALVTLTEAWEEAELDDa-----dSSR-----IGLVVGGSNFq---QRen----feVYERYQDrs-- 127  Bacillus subti...
CCA59267      66 LLP---QTDRMTRLALVAADWALADAGVRPee---qdDFD-----MGVVTASASGg---FEfgqg-elqKLWSQGs---- 126  Streptomyces v...

3HHD_C       129 --lVGYS-MVGC--QRAMMANRLSFFFDFRGPSIALDTACSSS-LMALQNAYQAIHSGQCPAAIVGGINVLLKPNTSVQF 202  human
P39525       151 --kRINPyFVPKi-LTNMAAGNVSIKFNLRGLSHSVSTACATGnNSIGDAF-NFIRLGMQDICVAGASETSLHPLSLAGF 226  Saccharomyces ...
O25284       131 --rKVNPfFITSa-LVNMIGGFTSIEFGIKGPNLSSVTACAAGtHAIIEAV-KTILLNGADKMLVVGAESTICPVGIGGF 206  Helicobacter p...
Q9I3B2       126 ---RIGPyRVTRt-MGSTVSACLATPFQIKGVNYSISSACATSaHCIGQAM-EQIQLGKQDVVFAGGGE-EEHWSQSCLF 199  Pseudomonas ae...
P52410       188 --rRISPfFIPYa-ITNMGSALLAIDLGLMGPNYSISTACATSnYCFYAAA-NHIRRGEADMMIAGGTEAAIIPIGLGGF 263  thale cress
XP_002276214 270 --rKMNPfCVPFa-TTNMGSAMLAMDLGWMGPNYSISTACATSnFCILNAS-NHIIRGEADMMLCGGSDAAIIPIGLGGF 345  wine grape
P23155       132 ddrRSEPhLERAf-TPATLSSAVAEEFGVRGPVQTVSTGCTSGlDAVGYAY-HAVAEGRVDVCLAGAADSPISPITMACF 209  Streptomyces c...
1TQY_G       131 daaWLSRhMFDYl-VPSVMPAEVAWAVGAEGPVTMVSTGCTSGlDSVGNAV-RAIEEGSADVMFAGAADTPITPIVVACF 208  Streptomyces c...
P40804       128 --gFISP-AYGLsfMDSDLCGICTDQFGITGLAYTVGGASASGqLAVIHAI-QQVLSGEVDTCIALGALMDLSYMECEAL 203  Bacillus subti...
CCA59267     127 --qYVSAyQSFAw-FYAVNSGQISIRNGMKGPSGVVVSDQAGG-LDAVAQARRQIRKGTR-LIVSGGVDASLCPWGWVAQ 201  Streptomyces v...

3HHD_C       203 LRLG-MLSPE---GTCKAFDTAG---NGYCRSEGVVAVLLTKKSLA 241  human
P39525       227 IRAKsITTN-------GISRPFDtqrSGFVLGEGCGMIVMESLEHA 265  Saccharomyces cerevisiae S288C
O25284       207 ASIKaLSTRNd--DPKKASRPFDkdrNGFVMGEGAGALVLEEYesa 250  Helicobacter pylori
Q9I3B2       200 DAMGaLSTQYn-eTPEKASRAYDakrDGFVIAGGGGMVVVEGLeha 244  Pseudomonas aeruginosa
P52410       264 VACRaLSQRn--dDPQTASRPWDkarDGFVMGEG-AGVLVMESLEH 306  thale cress
XP_002276214 346 VACRaLSQRNn--DPTKASRPWDtnrDGFVMGEGAGVLLLEELEha 389  wine grape
P23155       210 DAIKaTSPNn--dDPAHASRPFDadrNGFVMGEG-AAVLVLEDLEH 252  Streptomyces coelicolor A3(2)
1TQY_G       209 DAIRaTTARn--dDPEHASRPFDgtrDGFVLAEG-AAMFVLEDYDS 251  Streptomyces coelicolor A3(2)
P40804       204 RALGaMGTDKyadEPENACRPFDqnrDGFIYGESCGALVIERKETA 249  Bacillus subtilis subsp. subtilis str. 168
CCA59267     202 LASDrLSTSE---EPARAYLPFDreaQGHVPGEG-GAILVMEAAEA 243  Streptomyces venezuelae ATCC 10712
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