4XT0,1K0D,1N2A,1U3I,1ML6,1GUH,1VF2,1B48,1M0U,1B4P,2AB6,3GTU,1C72,1BYE,3R2Q,1NHY,5DQS


Conserved Protein Domain Family
GST_C
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pfam00043: GST_C 
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Glutathione S-transferase, C-terminal domain
GST conjugates reduced glutathione to a variety of targets including S-crystallin from squid, the eukaryotic elongation factor 1-gamma, the HSP26 family of stress-related proteins and auxin-regulated proteins in plants. Stringent starvation proteins in E. coli are also included in the alignment but are not known to have GST activity. The glutathione molecule binds in a cleft between N and C-terminal domains. The catalytically important residues are proposed to reside in the N-terminal domain. In plants, GSTs are encoded by a large gene family (48 GST genes in Arabidopsis) and can be divided into the phi, tau, theta, zeta, and lambda classes.
Links
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Statistics
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PSSM-Id: 425439
Aligned: 34 rows
Threshold Bit Score: 58.0725
Created: 16-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4XT0_A       110 FCWCVSTIGWAFGIKAIaqkmsdeefeehinknvpipeqqlkwrrarnGFPQEMLDEEFRKVGVSVARLEETLS-KQDYL 188 Sphingobium sp....
1N2A_B       100 YIATELHKGFTPLFRPD--------------------------------TPEEYKPTVRAQLEKKLQYVNEALK-DEHWI 146 Escherichia coli
WP_012340393 101 llMLRIEQDWYPVLEKAe------------------------------KGSESERAIALKQLKEEILAIAPVFG-QSLYF 149 Histophilus somni
P04907       107 FHPNASPLVFQLLVRPLlg----------------------------gAPDAAVVEKHAEQLAKVLDVYEAHLA-RNKYL 157 Zea mays
1BYE_B       109 LNPILFQVLISPMLGG--------------------------------TTDQKVVDENLEKLKKVLEVYEARLT-KCKYL 155 Zea mays
P30110       111 YYPAISPVVFECIIIPFiipg------------------------ggaAPNQTVVDESLERLRGVLGIYEARLE-KSRYL 165 bread wheat
P32111        95 FWAKYVEDK-GAAVWKSf-----------------------------fSKGE-EQEKAKEEAYEMLKILDNEFK-DKKCF 142 potato
P34345       120 LTAVAHAVPLLFAVMR----------------------------------DRTLKDEKQRKVFEVLKQAENLLA--NDFY 163 Caenorhabditis ...
P40582       114 LQPPLMIEFILSKVKDSgmpfpi-------------------sylarkVADKISQAYSSGEVKNQFDFVEGEISkNNGYL 174 Saccharomyces c...
3R2Q_A        96 LADGIMDAGLVSVREQArp---------------------------aaQQSEDELLRQREKINRSLDVLEGYLV--DGTL 146 Escherichia col...

4XT0_A       189 VDTGYSLADI--CNFAIAN---GLQRPGGFFGdyv----nqEKTPGLCAWLDRINARP 237 Sphingobium sp. SYK-6
1N2A_B       147 CGQRFTIADA--YLFTVLR---WAYAVKLNL----------EGLEHIAAFMQRMAERP 189 Escherichia coli
WP_012340393 150 MSEEFSLVDC--YIAPLLW---RMQQLGVVFTg--------TGSKAIKSYMERVFQRD 194 Histophilus somni
P04907       158 AGDEFTLADAnhALLPALT---SARPPRPGCV---------AARPHVKAWWEAIAARP 203 Zea mays
1BYE_B       156 AGDFLSLADL--NHVSVTL---CLFATPYASVl--------DAYPHVKAWWSGLMERP 200 Zea mays
P30110       166 AGDSITFADL--NHIPFTF---YFMTTPYAKVf--------DDYPKVKAWWEMLMARP 210 bread wheat
P32111       143 VGDKFGFADI--VANGAAL---YLGILEEVSGivl---atsEKFPNFCAWRDEYCTQN 192 potato
P34345       164 AGSQPGYPDY--LSFPFFEkiwWSASLDGVVDlptiefpgeEEYPKLTKWFQKMISSD 219 Caenorhabditis elegans
P40582       175 VDGKLSGADI--LMSFPLQ---MAFERKFAAP---------EDYPAISKWLKTITSEE 218 Saccharomyces cerevisiae S288C
3R2Q_A       147 KTDTVNLATI--AIACAVG---YLNFRRVAPGw-------xVDRPHLVKLVENLFSRE 192 Escherichia coli K-12
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