7JKC,6UVR,6L3T


Conserved Protein Domain Family
Connexin

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pfam00029: Connexin 
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Connexin
Connexin proteins form gap-junctions between cells. They carry four transmembrane regions, hence why this family now includes Connexin_CCC, which represented the second pair of TMs.
Statistics
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PSSM-Id: 425429
Aligned: 180 rows
Threshold Bit Score: 156.523
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7JKC_A          3 DWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEEVWGDEQSDFTCNTQQPGCENVCYDRAFPISHVRFWVLQI 82 
XP_006000586    3 EWSFLSSFLEYLQNHSPMVGRIWLVVMLIFRILILATVASDMFEDEQEEFACNTLQPGCKQVCYDKAFPISHYRFWVFHI 82  coelacanth
XP_007255228    3 DFGFLSGLFESLQANSPMLGRFWLLLMLVFRMLILGTVASDMFEDEQEEFSCNTLQPGCKQVCYDQAFPISQYRFWVFHI 82  Mexican tetra
XP_004080280    3 EWGFLGSLFDTLSSHSPMLGRFWLFLMLVFRILILGTVATDMFEDEQEEFICNTAQPGCKQVCYDMAFPISQYRFWVFHI 82  Japanese medaka
XP_005448248    3 EWGFIGGFFKDFQTHLPMLGRCWLILVLVFRILILGTVASDMFEDEQEEFTCNTLQPGCKQVCYDEAFPISQYRFWVFHL 82  Nile tilapia
36_pfamImport   1 EWDFISGFFDALQTRSPMLGRFWLFLVLVFRIVILETVASDMFEDEQEEFTCNTLQPGCKQVCYDMAFPISQYRFWVFHI 80 
19_pfamImport   1 SWKYLDDVLLRLSKNSTLLGKYWIATVLLLRLVVLTVFGESVWSDEQREFTCNTKQPGCENVCFNTFAPVSNVRMWGLQI 80 
5_pfamImport    1 MWNILEKVSEQVSLYATLTGQVWYLLVYLFRLIVVVTIGSSVYSDEQSAFRCSTKVIGCDNVCYDKFAKISHIRFWAFQL 80 
34_pfamImport   1 KLGFLSSVLCKWHAQATLIGKYLLPVLLLIRFVMLGAAVQTAWLNDREEFLCSTQQPGCETACFDAVTPLSLPRLWTLQL 80 
4_pfamImport    1 EESVLSRLLALWHSHAGFLGKTVLPVLQLVRIVLVGAAVQPVW--SNDYFVCDTNQPGCSSAAYNAVFPFSVHQYWTLQV 78 
7JKC_A         83 IFVSTPTLIYLGHVLHLVRMEEK-RKE--REeeppkaAGPAEEHQDPAPVRDDRGKV-----R-I--------------- 138
XP_006000586   83 VLLSGPSICFVIYAMHHASKIEKeKEA--LE------SGVSSNKSKRQTYNQ---------------------------- 126 coelacanth
XP_007255228   83 VLISTPALVFLMYAMHHHKKHQD-FQQ--------------GSVSSLLVAKQ---------------------------- 119 Mexican tetra
XP_004080280   83 VLIATPSLLFLLYATHHHNKRAN-------H------SDSCLRSSKNFREEK---------------------------- 121 Japanese medaka
XP_005448248   83 ILIATPSLLYFVYVTHQDHKRAN-------S------SSSRKRSSRKNREGR---------------------------- 121 Nile tilapia
36_pfamImport  81 VLIATPSLLYLIYATHQHHKRAN-------R------SSSRKKTSRENREEK---------------------------- 119
19_pfamImport  81 LAVSVPGALYFVYVMHVVSVSNE-------N------DKVKTSDLSTAANERVRTANkrwkvLtNhvips---------- 137
5_pfamImport   81 LALSAPVIVFHFYTIHVKGRIEK-LKVkeQE------AIEREEQYQKELTKTEDTSKwgvirNsVnnkiqrrksrigkvr 153
34_pfamImport  81 VLVLAPGLVFLCYLIHLTNQETQ---------------------VQRGNDEV---------------------------- 111
4_pfamImport   79 VFVLAPGLIYLFVRFLSPLFLHQ-----------------------SETGTVi--------------------------- 108
7JKC_A        139 ----------------AGALLRT-YVFNIIFKTLFEVGFIAGQYFLY--GF-QLKP-LYRCD-RWPCP-NT-VDCFISRP 194
XP_006000586  127 ----------------EDNLRKI-YIGNVAFRLLLEVGFTVGQWALY--GF-KVEA-QFPCE-RFPCP-YT-VDCFVSRP 182 coelacanth
XP_007255228  120 ----------------QRHLKLL-YMVNVGFRLLSEIGFLVGQWLLY--GF-RVEA-QFPCS-RFPCP-YT-VDCFTSRP 175 Mexican tetra
XP_004080280  122 ------------------RFKRF-YIINLLFRIGAEVGFIVGQWKLY--GF-EVKA-HFECE-RFPCP-KI-VDCFTSRP 175 Japanese medaka
XP_005448248  122 ------------------ALRAL-YIITVIFRIVGEIGFLFVQWRLY--GF-EVKA-HFPCS-RSPCP-LT-VECFTSRP 175 Nile tilapia
36_pfamImport 120 ------------------TLRAL-YIITLIFRIVAEIGFLFVQWRLY--GF-KVEA-HFPCS-RSPCP-LT-VECYTSRP 173
19_pfamImport 138 -----------elhktRGQCIWRlYLLQIFSRMLIECVFIMLQYTVYfyRW-TVPQ-VFRCQ-VWPCP-HT-VDCFISRP 201
5_pfamImport  154 pkkvyantqleeitltRG--IKVaYFLSVLTRFVMEIIFLFLAYDLF--RFaEYPHtPNDGRiVSDGNsDAyIPCWVSRP 229
34_pfamImport 112 ----------------KGHTLSV-YRACMAFVIVVEVGCSAAQWCLY--GF-ELST-DFSCG-RSPCP-MR-VDCFLSHA 167
4_pfamImport  109 ----------------KRQSLWA-YLGFLSAVVLLELGFAVGQCLKF--GL-FLPP-MFNVA-VSPCP-HT-VDCFLSQP 164
7JKC_A        195 TEKTIFILFMLAVACVSLLLNVLEIYHLGW 224
XP_006000586  183 MEKTIFLLFYFAVGVLSAVLSLVELITIIL 212 coelacanth
XP_007255228  176 MEKTVFLVFYFAVGVLSAVSSLVEIIHVTR 205 Mexican tetra
XP_004080280  176 AEKTIFLHFYFFVGVLSAFISFLELCYCTV 205 Japanese medaka
XP_005448248  176 KEKTIFLLFYFAVGVLSAFSSVveffyvsr 205 Nile tilapia
36_pfamImport 174 AEKTIFLLFYFAVGVISAFSII---TYLCV 200
19_pfamImport 202 QEKTVFFRYMYVISAFSILLSIGELLYIGW 231
5_pfamImport  230 WEKTIFLRYMNTLSVICLFLALAEIIQIGI 259
34_pfamImport 168 WEKTVFLRIMFTASSVSILLNVVEAVCMLR 197
4_pfamImport  165 NEKSVFMFIMLVLACLSGLLTLVEM----- 189
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