Conserved Protein Domain Family

pfam00023: Ank 
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Ankyrin repeat
Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
PSSM-Id: 425426
Aligned: 1062 rows
Threshold Bit Score: 25.3281
Created: 26-Apr-2021
Updated: 29-Sep-2021
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
2DZO_C   71 SGWTPFHIACs---vGN-----------LEVVK-S---LYd--RplkpDL-NKITN 105  baker's yeast
O73630  500 NGDTPLHLAVihgqsS--------------VIEqLvqiIL--------SIpNQQIL 533  African clawed frog
Q8LPS2  399 DGNTPLHLAVmnwdfD--------------SIT-C---LAs--Rn--hEI-LKLRN 431  thale cress
O23295  425 DGNTPLHLAVm---nWH-----------FKSIT-W---LA---Rs--sKI-LKVRN 456  thale cress
P72763  345 EGKTPLMLAAm---aNL-----------AAVIT-T---IAn-ySv---QV-NRGDP 377  Synechocystis sp. PCC 6803
P93755   90 DYRTPLMVAAtygsiD--------------VIK-L---IVsltDa---DV-NRACG 123  thale cress
O15084  238 YGNTPLHVACy---nGQ-----------DVVVN-E---LId-cGa---IV-NQKNE 270  human
O16004 1849 DGLTPLMLAVm---rSKasitdqeeethAHFIE-D---LIt--Rg--gDI-NHRTE 1892 green sea urchin
Q02979  427 YKRTPLHYSCq---yGL-----------SEVTK-L---IIk-lMk---EW-NIWNE 459  Saccharomyces cerevisiae S288C
P23631  862 NSDTPLNLAAq---nSH-----------IDVIK-Y---FId-qGa---DI-NTRNK 894  black widow
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