7DTT,6W2X


Conserved Protein Domain Family
7tm_3
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pfam00003: 7tm_3 
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7 transmembrane sweet-taste receptor of 3 GCPR
This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G pfam07562, which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor pfam01094. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness.
Links
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Statistics
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PSSM-Id: 425415
Aligned: 651 rows
Threshold Bit Score: 51.076
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7DTT_A        617 LSWTEPFGIAL------TLFAV-LGIFLTA---FV-L-GVFIKFR----NTPIVKATNRELSYLLLFSLLCCFSSSLF-- 678 
XP_028912976    8 EPLGMVLVSLA------LCFSL-LTALVLG---VF-I-HHRETSI----VKANNHSLSYTLLTALLLRFLSSLTFVGH-- 69   platypus
XP_002107624  384 LNVSEMVYMIV------MIHVG-LVFATSC---IL-M-AIYFYYR----KEPPIATSNIILDLFMGFGTLLCLSYVGF-- 445  Trichoplax ad...
XP_002107647  423 RMVGFNLYFGT------CLAAG-SAAGITL---FF-L-LVNTIFQ----NHRYIRLTNPGINNVLLFGILISYATIPLle 486  Trichoplax ad...
H2L0Q3        442 MTVSNEFYYPT------ILFAV-LGIAACV---FI-Y-LFTQKHH----ERLIIFQSQPECNNILLIGCSLCLFSLFL-- 503  Caenorhabditi...
EFO21587      441 LTVDLELYYAI------ALLAV-VGIFVAC---II-F-IFNIRNS----DRMIIMESQPQCNNVLLAGCILCCLSLLL-- 502  eye worm
XP_009023962  450 RTISFVSFASM------CFLAA-FGIFCSV---FL-L-VLNAAHR----LQMDNQKSRNCMNTVMLLGCLLCFVCIFI-- 511  Helobdella ro...
XP_020480717  496 RLLSQKLFAAV------SVFAG-LGILLGI---LC-L-TFNIYNG----NVRYIQNSQPYLNNMTAVGCMMALAAVFP-- 557  swamp eel
EEN52307      426 RLVSMELYVGM------CSSAL-VAMLAAF---GC-L-VFNVLNR----NVRYITMSQPGLNNIAVLGCITCLSCIFL-- 487  Florida lancelet
Q0IHS7       1287 AYVIEDNKQLIlegqhhVSLSTvGAEALSFpqkQEqPeMVLLKFTrsenNAALVTPSPEQLSNLIKTS--LHYPESFNhp 1364 tropical claw...

7DTT_A        679 FIgepQd------------WTCRLRQPAFGISFVLCISCILVKTNRVLLVFE-------------AKI------------ 721 
XP_028912976   70 PSlatCl------------LQQMNFRVIFSVAISTVLAKTVTVILAFKATGQgsrmrtwlgskasSSI------------ 125  platypus
XP_002107624  446 LC---LengivdpnnkilaFLCTFRSWLLAVGFSITLGCIFANSWSTYRSLS-------------GRSyrlrk------- 502  Trichoplax ad...
XP_002107647  487 ----iNyfgdrs--snflnMLCLLRYWVLLMGAIIPYSVMVAKMWRTYAVVTnivragk--------------------- 539  Trichoplax ad...
H2L0Q3        504 IG---LpsddisiseslfpLLCHARVTILLFGFTFAYGSMFAKVWIVHRMGA-------------TENqqlasrqkdeee 567  Caenorhabditi...
EFO21587      503 LG---LpargitipkhsftLLCHSQISLLMVGFTFAYGSMFAKVWVVHRLGA-------------AENqhlisrpt---- 562  eye worm
XP_009023962  512 NG---Ldarlvs--rltllKICQAQKWIFCFGFTLSYGAMFTKVWSIY---Rhtirqktgs------------------- 564  Helobdella ro...
XP_020480717  558 LG---Idghhvh--rsqfpVVCQFRLWLLGLGFSLAYGSMFTKIWWVHTLFT-------------KKDekkekkk----- 614  swamp eel
EEN52307      488 FG---Ldnssls--edqftAICQARTWVLVVGFTLAVGSMFSKIWRVHRlttrareedk--------------------- 541  Florida lancelet
Q0IHS7       1365 FQqksL---------------CL-----------VPVTLVLSNSSQAE-------------------------------- 1386 tropical claw...

7DTT_A        722 -----------------------------------------------PtsfhrkwwglnlQFLlVFLCTFMQIVICVIWL 754 
XP_028912976  126 -----------------------------------------------I------------CIC-SLIQVAICTVWLGISP 145  platypus
XP_002107624  503 -------------------------------------------ikksH------------SYGiAMSIFIFNIILCSLRA 527  Trichoplax ad...
XP_002107647  540 -----------------------------------------dtyevaM------------AIVmTVIIA-IPAAILLLWN 565  Trichoplax ad...
H2L0Q3        568 ntpwegirtlistmvgrqalmrkssgqaygallekrntvlnqpisssK------------FYViVAALTAVDVFVCFVWV 635  Caenorhabditi...
EFO21587      563 ---------------------------------------tgqsvpacK------------FYLvVTAFFVVDVIIITCWF 591  eye worm
XP_009023962  565 --------------------------------------htvhvttesF------------FVIiIC--LVVDVIILSVWQ 592  Helobdella ro...
XP_020480717  615 -----------------------------------------qhlepwK------------LYAtVGVLLAIDFLSLMVWQ 641  swamp eel
EEN52307      542 -------------------------------------vqfsdvveawK------------LYAlLGLFLAVDVIIMTVWQ 572  Florida lancelet
Q0IHS7       1387 ----------------------------------------------------------------------VDVIV---DL 1393 tropical claw...

7DTT_A        755 Y---TaPPSSyr--------nqE----------LE--DEIIFITC-HEGSlMAL-GFLIGYTCLLAAICFFFAFKSRKLP 809 
XP_028912976  146 R---FpDVDVts--------eaG----------VI--IVQCNEGSpTAFY-CIL-GYMGLLALVSLTVAFLARKLPDSFS 200  platypus
XP_002107624  528 Tv--D-QVEIfndtiws----------qrqiqsDGdiFVLQVRIC-RFSKyIVWdAVIFGINGIILLFGAITAWQAQRID 593  Trichoplax ad...
XP_002107647  566 Iv--D-PVHiqdrig-kirdddGnei----------lshRLACSC-QSy--QYFlGSIYGYFTLLVLCGLYLAKET---- 624  Trichoplax ad...
H2L0Q3        636 Li--D-PLHLte--------qkFplftp-adseEDemIMPVLQQC-QSNQqEVWiGIIMGFKCLLLVFGTFLSYETRNLK 702  Caenorhabditi...
EFO21587      592 Tf--D-PIQRve--------qrFplqeppmgteEDvmLLPILELC-QSKRqEMWtGLVMGYKCLLLVLGLFLAYETRNLK 659  eye worm
XP_009023962  593 Li--N-PTIIel--------elFtlenklniykDDteVIYELEHC-SSHNySTWfGIMAGFKGILLLFGLLLAYEIRNIK 660  Helobdella ro...
XP_020480717  642 Iv--D-PLHItv--------ekFtkea--pkedLDvlIQPLLEHC-SSEKmNTWlGVVYGYKGLLLLLGIFLAYETKSVS 707  swamp eel
EEN52307      573 Lt--N-PMTRya--------lqItchsqssismLGvaAVPNVTYC--------------GSKCIAAGQYLFL-YTCHGSG 626  Florida lancelet
Q0IHS7       1394 RhkaRsPEALethgsftwlgqtE-------------------------------------YKL-----------QLRSHE 1425 tropical claw...

7DTT_A        810 ---ENFNEAKFITFSMLIFF---------------IVWISFIP-AY--Ast------ygKf-vS-AVEVIAILAASFGLL 860 
XP_028912976  201 ---EAKFITFSMLVYCRIWV---------------SFLPIYLS-TK--Gka------mvAv-eV-FSILSSSTGILGFGP 251  platypus
XP_002107624  594 i--TNSNYVRYLAITAYNL----------------IISTSVAVtMSivIv--------eRptvRfVLISFFIILSSLSTN 647  Trichoplax ad...
XP_002107647  625 ------HQISSVILTDAKWI---------------SISAVNYA-LYvaAapigffaglnSpdvNfAILSLAIIYVSTSAV 682  Trichoplax ad...
H2L0Q3        703 l--RFINDSRFVGLAIYNVA---------------VMTLVTAPvVTllIh--------gKvdaNfAFISLTVLICTYISV 757  Caenorhabditi...
EFO21587      660 p--LFVNDLRFVGLAIYNVA---------------VLSLITGPiVTflIr--------sQsdaNfAFISITVLLSTYITL 714  eye worm
XP_009023962  661 l--NEANESRFVCVSIYNTV---------------ILCVITVP-AAwiIr--------sHqdaTyLFVSIAILLGNLFFM 714  Helobdella ro...
XP_020480717  708 t--EKINDHRAVGMAIYNVA---------------VLCLITAP-VTmiLs--------sQqdaSfAFASLAIVFSAYITL 761  swamp eel
EEN52307      627 l--L-----RTVARAWHWKAnpypapsactylytwVLCLITAP-VTilIs--------sQqdaTfAFTSLAILFCTVITL 690  Florida lancelet
Q0IHS7       1426 vftLQLK-ACFLHTGIYNLG---------------------TPrVF------------------------AKLANQLTLF 1459 tropical claw...

7DTT_A        861 AciFFN---K 867 
XP_028912976  252 K--VYV---I 256  platypus
XP_002107624  648 CltYLP---K 654  Trichoplax adhaerens
XP_002107647  683 LiiFVP---A 689  Trichoplax adhaerens
H2L0Q3        758 GliYGP---K 764  Caenorhabditis elegans
EFO21587      715 GlvFLP---K 721  eye worm
XP_009023962  715 FviFVP---K 721  Helobdella robusta
XP_020480717  762 VvlFVP---K 768  swamp eel
EEN52307      691 GliFIP---K 697  Florida lancelet
Q0IHS7       1460 EanQQSsmpA 1469 tropical clawed frog
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