Conserved Protein Domain Family
LmbU_fam_TF

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NF038070: LmbU_fam_TF 
LmbU family transcriptional regulator
LmbU is a well-described member of a family of DNA-binding transcriptional activators for natural product biosynthesis in Streptomyces and related species. Besides LmbU (lincomycin), some other members include CouE (coumermycin A1), CloE (clorobiocin), and HrmB (hormaomycin).
Statistics
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PSSM-Id: 411653
Aligned: 25 rows
Threshold Bit Score: 227.172
Created: 24-Apr-2023
Updated: 3-May-2023
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_011603698   9 KSGMTFPQNLSERSWEKIGISLRELTNSSAWWLADWLIFGEAAYGwRRYQEAIERTGLDYQTLRNYAWVARRFEHHRRRD 88  Frankia
WP_016638465  36 KSGMVLPQDLSERSWERIGSSLRELTNSSAWWLADWLIFGETAYGwRRYREAVDRTGLDYQTLRNYAWVARRFEHSRRRD 115 Streptomyces au...
WP_018803936  25 KAGILFPQNMSERSWEQIGTSLREIANSSAWWLADWLIYGEAAYGwRRYREAIERTGLDYQTLRNYAWVARRFEHHRRRE 104 Salinispora
WP_018803925  12 RSGIRFPPGLSQHAWEEIGVQLHEISSSSAWWLADWLIFGESAYN-GRYREAIKRTGLDYQTLRNYAWIARKFPHERRHE 90  Salinispora are...
WP_018254321  57 KAGILFPSGLAQHVWEDIGMQLQMASNSSAWWLADWLIFGETAFS-GRYREAIKRTGLDYQTLRNYAWIARKFPHERRVA 135 Salinispora moo...
WP_011605743  38 RVGLRIPGALTFERWQDTGSQISRLVDSSAWCLGDWLVYGQKEFS-DRYLRAIEVCGLDYQTLRNYAWVARKFDLDRRRE 116 Frankia
WP_015103233  38 RVGLRIPDALNFDIWERAGLQLSRIADSSAWCLGDWLIYGQSNYV-GRYRQAVEMAGLEYQTLRNYAWVARRFELWRRHE 116 Saccharothrix e...
ABX00623      32 RVGLRIPAVLNFDTWERAGRHIARVADSSAWCLGDWIIYGQTRYS-DRYRRAVEAAGLDYQTIRNYAWVARRFDLSRRRE 110
WP_007455667   5 RVGLRISAGLDYEVWERAGQRIARVADSSAWCLGDWIIYGESRYT-DRYRRAVKAAGLDYQTIRNYAWVARSFDQSRRRS 83  unclassified St...
WP_003962804  49 QVELRIPAGLPFDSWCRLGSQIKRVSESSVWWLADWLVFGEEEYP-DRYQVVIKRTSLSYQTLRNYAWVARKFPVARRRD 127 Streptomyces cl...
WP_011603698  89 GLSFAHHAEVTRLSTPEQDYWLRKAEQQNWSRNELRRAIRASLaeqsqedelpeqggderraaprpiRSTSAGRRRQQAT 168 Frankia
WP_016638465 116 SLSFAHHAEVTRLSPPEQDYWLRKAEQQKWSRNELRRAVRASLaeqsgpadtpar-ggeqqevaqlaDAQAADKNRRNVT 194 Streptomyces au...
WP_018803936 105 SLSFAHHAEVARLSAPEQDYWLRKAEQQKWSRNELRSAVRASVaernqevdrprssgdelqgvpqlaESTGAERRRRKTT 184 Salinispora
WP_018803925  91 SLSIAHHAEVARLGEPEQDYWLRKAADEQWSRNRLRRELRVSLaere----------------dghpADDEGAENAAQAG 154 Salinispora are...
WP_018254321 136 SLSIAHHAEVARLSEPERAYWLRRAEEEQWSRNRLRREVRHSLaergt--------------ddwqtSSSERCEGSAKPT 201 Salinispora moo...
WP_011605743 117 TLSFQHHVEVSSLPPHEQDRWLDLADEFNWSRNELRRNIRAHR------------------------QPDEKGAARPSGS 172 Frankia
WP_015103233 117 KLSFQHHAEVAALSPDEQDKWLTRAEQGNWSRNQLRNHRRLAE------------------------NNGQIPEPV-SVA 171 Saccharothrix e...
ABX00623     111 ALSFQHHAEVAALPEEQQDHWLEQAERHEWSRNELRRNVRGAR------------------------GQKKSDTRRDADV 166
WP_007455667  84 SLSFQHHAEVAALAPEQQDYWLDQSKRFGWSRNELRKNVRGAQ------------------------RGKPAPAAV-PEA 138 unclassified St...
WP_003962804 128 ALSLQHHAETAALPADEQDRWLERAERERWSARRLRRELRGHH------------------------AVDGGAAAR---V 180 Streptomyces cl...
WP_011603698 169 TLTIELSAGQLDSYSKVAAAHGLPVGKWVTQVLDAA 204 Frankia
WP_016638465 195 TLTLELSAGQLASYSQVAAAHGLPVDKWVTQVLDAV 230 Streptomyces aurantiacus
WP_018803936 185 TLTIELSARQLDCYSKVAAAHGMPVEKWVTQVLDAA 220 Salinispora
WP_018803925 155 SNQVELPPEQIEYCVRAADSCGLPLDEWVAHVLRSV 190 Salinispora arenicola
WP_018254321 202 AIQVRLAPEQLDLCVRLASSCGLSLSEWVENLVRSA 237 Salinispora mooreana
WP_011605743 173 LPKLTVPAERLLQWRRAADLSGEKFEQWVLRALDEA 208 Frankia
WP_015103233 172 LLKLSVDHEQIEQWREAARRSSKRYEQWVMTALDAA 207 Saccharothrix espanaensis
ABX00623     167 LSRITPEAERVERWRTAAERSGASLEEWICARLDFA 202
WP_007455667 139 VPQIKASPERVQRWRLAAERSGNTLEGWISARLDAA 174 unclassified Streptomyces
WP_003962804 181 QVTLNLDSERRGRWTQAAEAAHVPLMEWIVRTVDDA 216 Streptomyces clavuligerus
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