Conserved Protein Domain Family
CehA_McbA_metalo
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NF038032: CehA_McbA_metalo 
CehA/McbA family metallohydrolase domain
This domain, a branch of the PHP superfamily, is found in several partially characterized metallohydrolases, including McbA and CehA. Both were studied as hydrolases of carbaryl, a xenobiotic compound that does not contain a phosphate group, suggesting that presuming members of this family to be phosphoesterases (like many PHP domain-containing proteins) may be incorrect.
Links
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Statistics
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PSSM-Id: 411625
Aligned: 57 rows
Threshold Bit Score: 186.37
Created: 19-Oct-2021
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_010588133 309 GWISGDHHVHAAGcSHYdspteGVTPGDMLRHILGEDLNIGCVLSWGPCWytQKRYFEGKTs-------aLSRPNYLMRY 381 Schlesneria pal...
WP_012889887 276 GWYGGDMHAHLNWaGDM-----VGTPALAAAMQHGEDLHVLNLVAGNVSS--ERVYDSEALahwagrdlpWSDGTHLARI 348 Streptosporangi...
WP_011506310 446 HWYGADLHHHANV-LEG-----TTPPTTVVRAQLATDLDLTFISDHDSTA--NHDTFRKL----------SAERGVPFIP 507 Chromohalobacte...
WP_006740829 445 HWYGADLHHHGNV-LEG-----VTPPEIVVRAQLATDLDLTFISDHDSTI--NHQKFAEL----------SAKRGVPFIP 506 Vibrio antiquarius
WP_018982352 442 QWYSADLHHHGNI-LEA-----ITPPETVVRAQLAAGLDVIFISEHDSTI--NYAAFAEL----------SDKRGVPFLP 503 Salinimonas chu...
WP_006013428 449 GWYAGDLHHHSDV-LEG-----STPAEYLVRSQLAAGLNVTFVSDHDSTK--NNADIQAL----------SDKRGVPFIP 510 Glaciecola pall...
WP_013783864 450 GWYAGDLHHHADV-LEG-----STNPTNLVRSQLAAGLNVLFVSDHDSTK--NNDTIQTL----------ADARDVPFIP 511 Alteromonas nap...
WP_007426076 441 GWLASDMHHHADQ-LEG-----TTPPEWVARSELAAGLDVIFVSDHDSTA--NYETLASI----------AEDRDVPFIP 502 Oceaniovalibus ...
WP_012624285 496 KWYSADIHQHSDI-GDG-----ATPIKELHKGQLAAGLVCLAVSDHDSVG--NNAEMEKL----------AKSTGNPFLS 557 Desulfovibrio
WP_011879572 493 KWYCADNHQHSDK-GDG-----ATPIGELYKAQIAAKLDLNIVSDHDSVG--NNAKLAAL----------AKEGNRPFIS 554 Desulfotomaculu...

WP_010588133 382 DVEVS-GFpsshAGHLCLLKLIED---DYPGTTLLEEwPSwtQPVLEWGQKQGG-VVGYSHSGwglalpdvmpdgsrkfS 456 Schlesneria pal...
WP_012889887 349 GVEYRnDL----LGHLYAFGVSAPps-rFHTGFLGTAdWPpnSVACEELRGLGA-LLGYSHPFhnpi--------sdtdG 414 Streptosporangi...
WP_011506310 508 SIEIS-PS----WGHMNPFPIEMNgelE---VDPGTD-DV--QEIVKDAHRLGAeVVPMNHPY----------------N 560 Chromohalobacte...
WP_006740829 507 SIEVS-PS----WGHMNPFPIDNGaelK---VDPGTA-DV--HTLLNAVHEMGAeVVPMNHPY----------------N 559 Vibrio antiquarius
WP_018982352 504 SIEIS-PS----WGHMNPFPIDLDatlN---ADPGTD-DI--HTLMAAIREMGAsVVAMNHPF----------------N 556 Salinimonas chu...
WP_006013428 511 SIEIS-PS----WGHFNVFPVEIGaqlS---VDPGVD-DI--HNIIKDARHMGAtVVASNHPY----------------I 563 Glaciecola pall...
WP_013783864 512 SIEVS-PS----WGHFNAFPIDSGaqlT---VDPGVD-DI--HTIIEDVRRMGAtVIASNHPY----------------I 564 Alteromonas nap...
WP_007426076 503 SIELS-PS----WGHFNAYPLDLDaelQ---VDTSTA-TA--AEILAEARRMGAdAIQSNHPF----------------I 555 Oceaniovalibus ...
WP_012624285 558 SLEVS-PG----WGHWGILGVDH-------KQKPISP-DLtpAEIIKAGHAMGA-LVVMNHPY----------------T 607 Desulfovibrio
WP_011879572 555 SMEVS-PG----WGHWGILGMDY-------TKDPISA-NFtpAEIIKAGHDMGA-LVVVNHPY----------------S 604 Desulfotomaculu...

WP_010588133 457 DKPNGGAS--AGWQGkAAEKLPdlamprfdgigANEFIVTAtnGTCDfisav--dtpaIW-ELNIWYHTLNCGMRTRISG 531 Schlesneria pal...
WP_012889887 415 PGHLLWQGrnCSSREiVADAALg----------LVDSLDVL--NHTS-----------IAaTAAVYRHLIGAGNRIAVTA 471 Streptosporangi...
WP_011506310 561 AYGYLSNL--GDGKV--PGGFTp----------GFDLLELN--AEVDne-------ptIAaAHRFW----DQGTRLYFTA 613 Chromohalobacte...
WP_006740829 560 DYGYFTNI--AKNAV--PGGKTd----------RFDLMELN--ARVDne-------ptLKkAHKLW----DLGEAMYFTA 612 Vibrio antiquarius
WP_018982352 557 DYGYYANL--KKGVV--PGGESd----------GFTLLELN--AAMDnt-------ktVNkAHSLW----DEGKKMYFNA 609 Salinimonas chu...
WP_006013428 564 PYGYLSSL--SKNTA--PGGFNp----------TIDLIEIN--AVVDyn-------kaIEkARQLW----SEGLPYYYTA 616 Glaciecola pall...
WP_013783864 565 PYGYLSSL--DKGTA--PGGFNp----------SIDLFELN--AVVNne-------ptINkAHQFW----NEGLPYYFTA 617 Alteromonas nap...
WP_007426076 556 PYGYLASL--EAGTV--PGGFAs----------DIDLLELN--GPDDda-------rvFErAGHLW----SRGQRIYLSG 608 Oceaniovalibus ...
WP_012624285 608 DYGFLHNR--DGVKDgYAPGSD-----------DFDLLEIQ--STIDltdpknmdkraLDaAMDYW----NKGKKIYLSS 668 Desulfovibrio
WP_011879572 605 DYGFFKNR--AGVRGgYDKGSE-----------DFDFLELQ--STINltdaknmdklaLDaAMGYW----NKGIKKYLSA 665 Desulfotomaculu...

WP_010588133 532 ETDFPCIYGDKV------GLGRVYVKLplDQPVDYDTWVQGVKDGRSYCGDGLshLFDFAVNGfeagmtGPSGKSSQLdl 605 Schlesneria pal...
WP_012889887 472 GTDAMVSFARRGnqsnppGWARVYARV--EGPLTAGSFAEAVRRGRTFGTTGP--WLELSAGG------HGPGATLDLsp 541 Streptosporangi...
WP_011506310 614 GTDTHDAWNDLT------GRIRMMGHV--PGELTPRAFARALKDGHGYATQGP----LLFPEK------HMFGDSLRLve 675 Chromohalobacte...
WP_006740829 613 GTDTHDAWNQLT------GQIRMMARV--DGELTPSKFAQALKAGHGYATQGP----ILYPQN------IMFGETATA-- 672 Vibrio antiquarius
WP_018982352 610 GTDTHDAWNQKS------GNIRMMARV--PDPLSAQRFAEALKHGHAYATTGP----LLYPRN------IMFGDSADA-- 669 Salinimonas chu...
WP_006013428 617 GSDTHDVWNETS------GRNRMFVYT--GSKPDANAFAQAMKNGRSYASFGP----VIYPQN------VMFGDTVMLak 678 Glaciecola pall...
WP_013783864 618 GSDTHDVLNQTS------GLNRLFVYT--GSKPTAKGFAQAAKDGHSYVSYGP----VIYPKN------VMFGDTMKLak 679 Alteromonas nap...
WP_007426076 609 GSDAHDVWNDAT------GSARAYVHV--PGQPSAEGFVAGLKDGHAYVTRGP--LIAPD---------VMFGSALRIap 669 Oceaniovalibus ...
WP_012624285 669 GSDQHDVTSILYp-----GIIRTYAYV--DGKVSPKSYMAALKAGNSYVTMGP--VITPAAGS-------MFGSTRTIka 732 Desulfovibrio
WP_011879572 666 GSDQHDVTSGLYp-----GIIRIYAYI--DGNVTTENYLKALKEGHAYVTMGP--IFTPAPNT-------MFGSTQQVka 729 Desulfotomaculu...

WP_010588133 606 kepGKVRITCEAAALLaeKPTpqsdairakrldekpywhlerarigdtqivPVELIV-NGVPVEr------------kTI 672 Schlesneria pal...
WP_012889887 542 --gERVTVTARSAGPEv---------------------------------eRLEIRT-ADGVLA--------------EG 571 Streptosporangi...
WP_011506310 676 --dAKGEWTVNATAVN--DLA------------------------------EARLIG-QGGEVLa-------------TQ 707 Chromohalobacte...
WP_006740829 673 ----GDTWDIHVVAAD--GLK------------------------------EIRLIG-KGGNVLnt-----------lTI 704 Vibrio antiquarius
WP_018982352 670 ----ASSWEVDIEAVN--GIS------------------------------EIRLLGkEGQILKt------------kKL 701 Salinimonas chu...
WP_006013428 679 --nQPQSVSFDLLSVS--GLK------------------------------SVQLIG-NDGVIS--------------EQ 709 Glaciecola pall...
WP_013783864 680 --aQARTITFDLVAVN--GLK------------------------------SVQLIG-SDNAATatntqsaansvvleDK 724 Alteromonas nap...
WP_007426076 670 --gTERSVAFDLTAVN--GLV------------------------------RATLTG-PDGQIAs------------qDF 702 Oceaniovalibus ...
WP_012624285 733 --gETVTLSTELQAVH--GLK------------------------------SIEVYS-EGKPVSk------------kEF 765 Desulfovibrio
WP_011879572 730 --dGQYTLDTEIQAVN--GLT------------------------------RIDVYS-EGKVIAs------------kEF 762 Desulfotomaculu...

WP_010588133 673 PADGSLQNLTFDYDL--KQSS-WIALRIMPS-----------CHTNPVFVE 709 Schlesneria paludicola
WP_012889887 572 PPAELTCELVAGDPT-------YVVAVAVGGpheraltggayAHTSPVYLD 615 Streptosporangium roseum
WP_011506310 708 SLDGTDATLTFEIPG--DAKG-WVALEVDDAdg-------dtAWTNPLWLE 748 Chromohalobacter salexigens
WP_006740829 705 NPKVDTQRIELSLPIpsDAEG-WISLEVEDKdg-------stAWSNPVWLQ 747 Vibrio antiquarius
WP_018982352 702 KGEEITQKVQLKWIIptSAKG-WVSLEVDDKkg-------ntAWSNPVWIK 744 Salinimonas chungwhensis
WP_006013428 710 TLTGENASVVFDLP---QLSG-WVSLVVEDKkg-------hkAFSNPIWLK 749 Glaciecola pallidula
WP_013783864 725 TLTGDHDSVNFEVP---QVSG-WVALVVEDIeg-------rkAFTNPIWLE 764 Alteromonas naphthalenivorans
WP_007426076 703 ADSPMASTASFTVTAtpRDGTdWIALTVEDAeg-------kmAFTNPIWIN 746 Oceaniovalibus guishaninsula
WP_012624285 766 SDTKDAVTYTFEAAP--QKDT-WYNFVVMDGkg-------ryAVTNPVWVE 806 Desulfovibrio
WP_011879572 763 NNTKDAVKYTLNVKP--TKNT-WYSFVAVDGkg-------hyAVTNPVWVN 803 Desulfotomaculum reducens
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