Conserved Protein Domain Family
PE_process_PecA

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NF038019: PE_process_PecA 
PecA family PE domain-processing aspartic protease
PecA from Mycobacterium marinum, and by homology, three related paralogs from Mycobacterium tuberculosis (PE26, PE_PGRS35, and PE_PGRS16) are all PE domain-containing proteins secreted by a type VII secretion system (T7SS, also called ESX in Mycobacterium), and all share a C-terminal aspartic protease-like domain. PecA itself is now known to be a functional aspartic protease that cleaves within the PE domain of T7SS secretion substrates that have the domain, including itself. Members of this family typically contain a long, variable, low-complexity region. This HMM represents the aspartic protease region C-terminal to the low-complexity region.
Statistics
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PSSM-Id: 468313
Aligned: 8 rows
Threshold Bit Score: -1
Created: 24-Apr-2023
Updated: 3-May-2023
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_019737337    103 TFTVPMEVNAt---TEPVVSVSVGGGSAADVLVDTGAAGLVMPIWNInp-fGIT--GLPTGFNIGQFGGALDYF----YV 172 Mycobacteria...
3_ncbifamImport   1 NVAVPLRVEN----NFPLVNLLVNRGPTVPILLDTGSSSLVIPFWKI----GWQnlGLPTGFDVVHYGNGVSIV----YA 68 
WP_020732143    277 NVTVPLDVAEgyglTSPNVNVSVNGGPSVPVLVDTGSRGLVIPFWAV----GFQnlGWPTGIGIASYASGLDFV----TI 348 Mycobacteriu...
1_ncbifamImport   1 NATVPLQLVNt---TEPVVFISLNGGQMVPVLLDTGSTGLVMDSQFL-----TQnfGPVIGTGTAGYAGGLTYN----YN 68 
2_ncbifamImport   1 GRTVPLEIIHv---TEPTVHANVNGGPTSTILVDTGSAGLVVSPEDVggilGVLhmGLPTGLSISGYSGGLYYI----FA 73 
WP_015355774    263 GRTVPLEVVNv---TEPVVNVNVNGGHSTPVLIDTGSAGLVMQVKDVggplGLLrmGLPSGISMSAYSGGLTYL----FA 335 Mycobacteriu...
WP_013827289    110 SFTVPMDVNLt---TQPVINVSIGGGAQTEVLVDTGAAGLVVPIWNInp-fGIT--GLPTGFNIGQFGGALNYF----YV 179 Mycobacteria...
WP_020724987    207 ANEILMRVDQy---GNPVVTISVGGGPGIAVTVDTGASGLLVRPQDV----NLQslGTPTGSGAVTYGNSSYAFntvqYQ 279 Mycobacteriu...
WP_019737337    173 ELPTTVTFtdaAGDTVTADTSVDAVLFAFPADFNIFGPWS-----------IQDYLGPANvVGVLGVGPNAL-----GPT 236 Mycobacteria...
3_ncbifamImport  69 DVPTTVDF---GGGAATTPTSVHVGILPYPRNLDSLVLIA-----------SGGAFGPNG-NGILGIGPNVGsyavsGPG 133
WP_020732143    349 RFNTTVDF---GNGAVSAPTPVEVAVLPFPTTLNSLLIIAlspv---lqpvFGVGMFGLA-HGTLGVGPNAG-----GPG 416 Mycobacteriu...
1_ncbifamImport  69 TYSTTVDF---GNGLLTLPTSVNVVTSSSPGT-------------------LGNFLSRSGaVGVLGIGPNNG-----FPG 121
2_ncbifamImport  74 TYTTTVDF---GNGIVTAPTAVNVVLLSIPTSPFAISTYFsalladptttpFEAYFGAVGvDGVLGVGPNAV-----GPG 145
WP_015355774    336 TYPTTVDF---GNGIVTSTTGVDVVLFSIPTSPYALTTWLnalwsnplttpFDAYFQSAGvDGVLGVGPNAV-----GPG 407 Mycobacteriu...
WP_013827289    180 ELPTTVTFtgvDGDTVTADTTVDAVLFAFPADLNPFGAWS-----------IYDYLAQSS-TGILGIGPNAL-----GPT 242 Mycobacteria...
WP_020724987    280 TYQTTVNF---GNGIVTNPTNVAVATSATQTING-----------------VTTSIPLSSlPLYLGIGPNND-----FPL 334 Mycobacteriu...
WP_019737337    237 PdhIPTADLPGDLGKGLLIDQADKELIFGANPLT-GGTAVAGAPWTTLDLSING----STPQPVS-AVVDSGGVYGTMPS 310 Mycobacteria...
3_ncbifamImport 134 N--VVTTDLPGQLNEGTLIDIPGGYMQFGPNTGT-PITSVTGAPITVLNVQIGGydpnGGYWSLP-SIFDSGGNHGTLPA 209
WP_020732143    417 Is-SPTTALPGQLDEGVLVNAPQGELQFGPNSLP-SGISVPGAPITPLLVQVNG----GPLQPIT-AVIDSGGVDGTIPS 489 Mycobacteriu...
1_ncbifamImport 122 Ts-SIVTAMPGLLNNGVLIDESAGILQFGPNTLT-GGITISGAPISTVAVQIDN----GPLQQAP-VMFDSGGINGTIPS 194
2_ncbifamImport 146 Ps-IPTMALPGDLNQGVLIDAPAGELVFGPNPLPaPNVEVVGSPITTLYVKIDG----GTPIPVP-SIIDSGGVTGTIPS 219
WP_015355774    408 Ps-IPTQALGGGLGQGLLIDMQGGELVFGPNPLT-PNFSVSGAPISTLWVSVNG----GAPVAVP-SIIDSGGVMGTIPS 480 Mycobacteriu...
WP_013827289    243 PahIPTADLPGTLGNGVLIDQPNGQLIFGDNPYE-NGTVIAGSPWADLKVQLND----GPLTDVK-AVIDSGGVYGTMPS 316 Mycobacteria...
WP_020724987    335 Pd-QVTAALPGDLNQGVLINTNLGYLQFGANPLT-PVASVTGSPVTDLQIQINN----GPLQPATgSFIDSGGLYGTIPS 408 Mycobacteriu...
WP_019737337    311 SVLn--GIQPQqNGGLPDGTTIAVYQ-HGTNNLLYEYTvhnvNGVFNSPTVTSGDT-MNTGNIPFAQQPIYISYSPAGGG 386 Mycobacteria...
3_ncbifamImport 210 VIL---GTGQT-TGYAPPGTVISISI-HDNQTLLYQYT----TTASNSPVVTADPR-LNTGLTPFLLGPVYISNNPSGVG 279
WP_020732143    490 SVL---GTGQV-SGTVPAGTTISVYT-SDGSTLLYSYT----TTATNGPTVTSGTS-MNTGYLPFGQQAIYISNSPSGVG 559 Mycobacteriu...
1_ncbifamImport 195 ALA---SL-PS-GGFVPAGTTISVYT-SDGQTLLYSYT----TTATNTPFVTSGGV-MNTGHVPFAQQPIYVSYSPTAIG 263
2_ncbifamImport 220 YVI---G-----SGTLPANTNIEVYT-SPGGDRLYAFN----TNDYR-PTVISSGL-MNTGFLPFRFQPVYIDYSPSGIG 284
WP_015355774    481 SVI---G-----GSTLPANTNITVYTdSTMTNEVYHYS----TNDYQ-PTVISSGL-MNTGFLPFWMQPVYIDYSPAGTG 546 Mycobacteriu...
WP_013827289    317 SVLtgaGVTPTaSGTLPNGTEISVYA-KDG-TLLYNYIvgsqAGEVRSPVVVGANSgMNTGNWLFAQQPVYINYGVPG-G 393 Mycobacteria...
WP_020724987    409 SLIp--GV-PV-GYSVPVGTTITVYT-TDGVQLYSQTV----TGSTNAPLVVPSNNpFNTGNYPFLLGPIYISNSPTGGG 479 Mycobacteriu...
WP_019737337    387 QTIFG 391 Mycobacteriaceae
3_ncbifamImport 280 TVVFN 284
WP_020732143    560 TTIFH 564 Mycobacterium marinum
1_ncbifamImport 264 TTTFN 268
2_ncbifamImport 285 TTVFD 289
WP_015355774    547 TTVFN 551 Mycobacterium ulcerans group
WP_013827289    394 QTIVG 398 Mycobacteriaceae
WP_020724987    480 QTIFD 484 Mycobacterium marinum
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