Conserved Protein Domain Family
rSAM_mat_DarE
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NF038005: rSAM_mat_DarE 
darobactin maturation radical SAM/SPASM protein DarE
The radical SAM/SPASM protein DarE is a maturase for the ribosomally translated, post-translationally modified peptide natural product (RiPP) darobactin, including forms A, B, C, D, and E. The mature form is just seven amino acids long, with two cross-links, a Trp1-Trp3 linkage and a Trp3-Lys5 (or Arg5) linkage.
Links
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Statistics
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PSSM-Id: 411598
Aligned: 22 rows
Threshold Bit Score: 780.369
Created: 24-Apr-2023
Updated: 3-May-2023
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_087813499   1 MRETIPIKYIDTIEINKLSIQDLEDLSSCKYKLLSAYLIGKIPANKILDADELEIYHNERTKKILAKAIKARKLVIVLKA 80  Yersinia pestis
WP_049632707   1 MDDIIPIR-----NIENIDLQRLEEINSCDYKSLSAYLIGKIPANRLLDDEELGIYNSELTKNISAKAINAGKLVVVLKA 75  Yersinia aldovae
WP_145494393   1 MDNIIPVKYIDCAKINNIDIQELKEIDACEYKSLSAYLIGRIPAEDLLTSDELDTYNQEIDRELLVKEINAEKLVIVLKA 80  Yersinia massil...
WP_136991068   1 MNGLIPVTQIADDGFDHLEPQDFRQLAQQDYGQISAYLIGCIPAEKILSPDELRRYHEARERDITARSVNAGKLIVVLKA 80  Martelella alba
WP_063364333   1 MLGDISVKVIEEPVNP----VNQLELTDYQYSRLASQLIGEIPDSDMLDEEELALFRREKDAYFEAKPLNASKVVVVLKA 76  Pseudoalteromon...
WP_010604503   1 MLGDISIKVIDAAENSKE--TVDIEVSDYQYSRLASQLIGEIKDYDILDDEELALFREEKASDFKAKPLKASKVVVVLKA 78  Pseudoalteromonas
WP_132715539   1 MLGDISVKIVDEPISS----IEQLEVTDFQYNRLASQMIGEIKGSDILDDEELELFNFQMNKSFDAKPLRANKLVVVLKA 76  Vibrio crassost...
WP_113024446   1 MDTIIPIKYLDADGSS-----ILKKSPKINYRQLACRIIGEISAEKILDDDELALYNEEIGIHFSPEIINANKLVVVVKA 75  Photorhabdus la...
WP_065824696   1 MDTIIPIKHLDSAESS-----ILKKAPKINYRQLACRIIGEIPAEKILDDDELALYNEEIGLKFSPEVINANKLVVVVKA 75  Photorhabdus au...
WP_025420791   1 MNGIIPVKDITQASLDP----PFAKMASNHYRDLAAYMIGRLPAEQLLTRDERALYQRERQISPCAKPLGCGKLVVVLKA 76  Sodalis praecap...

WP_087813499  81 TRLCNLRCTYCHSWAEGPNQTILFSTLIHIVRQILAIPNVNRFEFVWHGGEVTLLKPAFFKKLIWLQEQFKRPEQYITNT 160 Yersinia pestis
WP_049632707  76 TRRCNLRCTSCHSWAEGPNQTVSFKTLICVIRKILAIPNVNRFEFVWHGGEVTLLKPLFFKKLIWLQQRFKRPEQYITNT 155 Yersinia aldovae
WP_145494393  81 TRLCNLRCTYCHSWAEGPNQTVSFDTLVRVVRKILAIPNISRFEFVWHGGEITLLKPLFFKKLIWLQQQFKRPEQYITNT 160 Yersinia massil...
WP_136991068  81 TRHCNLRCTYCHSWAEGPNQVLTFRTLAHAVRRILAIPNIRRFEFVWHGGEVTLLKPAFFKKLIWLQQKFKRSDQIITNA 160 Martelella alba
WP_063364333  77 TRLCNLRCTYCHSWAEGPNQTVKFENLISIVKRILAIPNVSRVEFVWHGGEVTLLRPAFFKKLIWLQEQFKRKDHFITNT 156 Pseudoalteromon...
WP_010604503  79 TRLCNLRCTYCHSWAEGPNQSIKFENLVSIVKRILAIPNVSRVEFVWHGGEVTLLRPLFFKKLIWLQEQFRRPDHFITNT 158 Pseudoalteromonas
WP_132715539  77 TRLCNLRCTYCHSWAEGPNQTIKFEILVTIVKRILSIPNVSRVEFVWHGGEVTLLRTEFFKKLIWLQEQFKRKDHVITNT 156 Vibrio crassost...
WP_113024446  76 TRLCNLRCTYCHSWAEGKGNTLTFFNLMRSIHRFLSIPNIKRFEFVWHGGEVTLLSVNYFKKLIWLQEQFKKPDQVITNS 155 Photorhabdus la...
WP_065824696  76 TRLCNLRCTYCHSWAEGKGNTLTFFNLMRSIHRFLSIPNIKRFEFVWHGGEVTLLNVNYFKKLIWLQEKFKKPDQVITNS 155 Photorhabdus au...
WP_025420791  77 TRCCNLRCTYCHSWAEGPEQTMSFAVLTRALRRILTLPDIHRFEFVWHGGEVTMLRPDFFKKLIWLQEQFRKPGDVITNS 156 Sodalis praecap...

WP_087813499 161 MQSNIVNISDEWLIFIKGIGMNVGISLDGIPAVNDKRRGGFRGRGTSGRIAKGIKKIQKNDILYGALIVVDREVYQTDMR 240 Yersinia pestis
WP_049632707 156 MQSNIVNISEEWLTFIKGIGMNVGISLDGVPAVHDKRRVDYRGRGTSERVARGIKKLRHHNILYGALIVVDRDVYQTDMK 235 Yersinia aldovae
WP_145494393 161 MQSNLVNISDEWLTFIKGIGMNVGISLDGIPTINDKRRIDYRGRGTSERVAKGIKKLLKYQILYGALIVVDREVYQTDKT 240 Yersinia massil...
WP_136991068 161 MQSNAVNISDEWLIFLKGIGMPVGISLDGVPHIHDRRRVDYRGRGTSERVARGIRRLRRYDIPYGALIVVDSEVYATDLR 240 Martelella alba
WP_063364333 157 MQSNAVNISKEWLTFLQGIGMAVGISFDGVPEINDTRRLDVRGRPTSLKVAEGIKRLQEYGIPYGALIVVDRDVYNVSPE 236 Pseudoalteromon...
WP_010604503 159 MQSNAVNISDEWLTFLKGIGMSVGISFDGVPEINDTRRLDVRGRPTSIKVAEGIRRLKHHGIAYGALIVVDKDVYNLDPE 238 Pseudoalteromonas
WP_132715539 157 MQSNAVNISQEWFTFLKGMGMSVGISFDGVPEIHDSRRLDVRGRPTSHKVANGIKQLKLYGIPYGALIVVDRDLYNIEPE 236 Vibrio crassost...
WP_113024446 156 VQTNAVNIPEDWLVFLKGIGMGVGISVDGIPEIHDSRRLDYRGRPTSHKVAAGMKKLRSYGIPYGALVVVDRDVYESNIE 235 Photorhabdus la...
WP_065824696 156 VQTNAVNIPEDWLVFLKGIGMGVGISVDGIPEIHDSRRLDYRGRPTSHKVAAGMKKLRSYGIPYGALVVVDRDVYESNIE 235 Photorhabdus au...
WP_025420791 157 MQSNAVSLSPAWLQFLEAIGMSVGISLDGVPAINDTRRLDKRGRGTAARVAETIGRLRERGIPYGALIVVDRQLYHSDMR 236 Sodalis praecap...

WP_087813499 241 EMLDYFILIELNGIEFLNIVPDNRLTAGEDIGNNFISYAEFIKFLSALFVIWIKGYREKIHIAIFEDFISVLEHPEKKLS 320 Yersinia pestis
WP_049632707 236 AMLDYFISIELTDIEFLNIVPDNRLVAGEYIGHDFISYAEFIEFLSVLFNIWINGYRESIYISVFEDFINVLKHPERKLS 315 Yersinia aldovae
WP_145494393 241 EMLDYFISIELTNIEFLNIVPDNRLVSGQDIGNDFISYDEFIYFLSSLFNVWITGYREKIRISVFEDFIRVLKNPDKELS 320 Yersinia massil...
WP_136991068 241 EMFDYFCAIDLTDIEFLNIVPDNRIPAGGEVGAGYISYADYIGFLSKAFVLWWGEYRGRLRIRLFSDFIRALGDPATPPS 320 Martelella alba
WP_063364333 237 RLLSYLASIELNDIEFLNIVPDNRAQPGDDIGDAYISYKEYIEFLSRVYTVWHAQYRGIIQIRMFENFMDVLADRSKQLS 316 Pseudoalteromon...
WP_010604503 239 RLLSYLHSIELNDIEFLNIVPDNRAKPGDDIGNAYISYKEYIEFLSCVYRVWYGHYKDKVRIRMFENFIDVLSDKTKQLS 318 Pseudoalteromonas
WP_132715539 237 KLLSYLTSIELNDIEFLNIVPDNRAKPGDDIGTAYISYQEYIKFLSDVYTVWYTSYQQKIQIRMFDNFIDVLSGKEKKLS 316 Vibrio crassost...
WP_113024446 236 KMLSYFYEIGLTDIEFLNIVPDNRCQPGDDPGGSYITYHNYINFLSNVFRVWWNGYQDKINIRLFHGFIDSIKSSQKKIS 315 Photorhabdus la...
WP_065824696 236 KMLSYFYEIGLTDIEFLNIVPDNRCQPGDDPGGSYITYHNYINFLSKVFRVWWDGYKGKINIRLFDGFIDSIKSSQKKIS 315 Photorhabdus au...
WP_025420791 237 AMLEYFRQIALTNIEFLNIVPDNRLTPNGDPGEGYITYRQFIAFLSKMFLLWWQNYRTVIAIPMFEDFIRVLSHPTARLS 316 Sodalis praecap...

WP_087813499 321 ACYWSGNCSQEIITLEPNGDVSPCDKYRGDAGSIYGSLLKTDLAGLLTQSSHNQQAIDEEVAATRKMQHCEWFSICHGGC 400 Yersinia pestis
WP_049632707 316 ACYWSGNCSQEVITLEPNGNVSPCDKYVGDIDSIYGSLLDTDLADLLAYSSHNQHAISEEIAATEKMRHCKWFPICHGGC 395 Yersinia aldovae
WP_145494393 321 ACYWSGNCSQEIITLEPNGDVSPCDKYVGDANSIYGSLLYDDLADLLAFSSHNRQAINEEITATEKMRHCEWFSICHGGC 400 Yersinia massil...
WP_136991068 321 ACYWAGNCSQEVITLEPNGYVSPCDKYVGDSGSLYGSLLETDLSTLLARSGHNRMALEEERRAMEKMRDCRWFSICHGGC 400 Martelella alba
WP_063364333 317 ACYWAGNCSQEIITIEPNGDVSPCDKYVGDIGSIYGSLLDSDLATLLADSKHNQTSVLEEVESHSRMHECKWFSICNGGC 396 Pseudoalteromon...
WP_010604503 319 ACYWAGNCSQEIITVEPNGDVSPCDKYVGDIGSIYGSLLNSDLATLLEKSNHNQASVKEEIDATDRMRECEWFSICNGGC 398 Pseudoalteromonas
WP_132715539 317 ACYWSGNCSQEIVTIEPNGDVSPCDKYVGEVGSIYGSLMESDLATLLENSRHNKDSIKEEVESHNRMGECEWFSFCNGGC 396 Vibrio crassost...
WP_113024446 316 DCYWAGNCSQEIITLEPNGTVSACDKYVGAKGNNYGSIIDNDLGHLLTKSNTNKNHLKEEIESYEKMHQCKWFHLCNGGC 395 Photorhabdus la...
WP_065824696 316 DCYWAGNCSQEIITLEPNGTVSACDKYVGAEGNNYGSIIDNDLGNLLAKSGTNKNHLIEERESYEKMHQCKWFHLCNGGC 395 Photorhabdus au...
WP_025420791 317 ACYWSGDCAREVITLEPNGTVTPCDKYVGMKNNNYGSLIDNDLATLLDSAAHYRRAAREARHARQAMKHCQWFTMCRGGC 396 Sodalis praecap...

WP_087813499 401 PHDRVINRRHTKGYNDECCGTGKLLATIKAYL 432 Yersinia pestis
WP_049632707 396 PHDRVINRRHTKGYNDTCCGTGKLLTTIENYL 427 Yersinia aldovae
WP_145494393 401 PHDRVINRRHTEGYDDTCCGTGKLLSTIRHYL 432 Yersinia massiliensis
WP_136991068 401 PHDRVINRRHVPGYDDRCCGTGRLLATIERCL 432 Martelella alba
WP_063364333 397 PHDRVINARHVEDYDDKCCGTGKLLKVIEESI 428 Pseudoalteromonas luteoviolacea
WP_010604503 399 PHDRVINARHVEDYNDKCCGTGKLLRVIEESI 430 Pseudoalteromonas
WP_132715539 397 PHDRVINSRHVEGYNDKCCGTGKLLKVIKESL 428 Vibrio crassostreae
WP_113024446 396 PHDRVTNRKHNPNYNDSCCGTGGLLETIKQTI 427 Photorhabdus laumondii
WP_065824696 396 PHDRVTNRKHNPNYDGSCCGTGGLLETIKQTI 427 Photorhabdus australis
WP_025420791 397 PHDRLINRRHAPDHEENCCGTGVLIETINQCL 428 Sodalis praecaptivus
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