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RumC family sactipeptide The founding member of this family of radical SAM/SPASM-modified sactipeptide bacteriocins is ruminococcin C1, AEC03333.1 from Ruminococcus gnavus. This bacteriocin, from a human gut bacterium, is interesting because of its anti-clostridial activity. Known homologs to RumC1 average about 65 amino acids in length and have four invariant Cys residues. This RiPP (ribosomally translated, post-translationally modified peptide natural product), in the ruminococcin C family, is modified by a radical SAM/SPASM domain protein to have several cross-bridges from Cys sulfur atoms to alpha carbons of another amino acids. It is therefore defined as a sactipeptide. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",