Conserved Protein Domain Family
RumC_sactiRiPP
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NF035950: RumC_sactiRiPP 
RumC family sactipeptide
The founding member of this family of radical SAM/SPASM-modified sactipeptide bacteriocins is ruminococcin C1, AEC03333.1 from Ruminococcus gnavus. This bacteriocin, from a human gut bacterium, is interesting because of its anti-clostridial activity. Known homologs to RumC1 average about 65 amino acids in length and have four invariant Cys residues.
Links
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Statistics
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PSSM-Id: 411535
Aligned: 15 rows
Threshold Bit Score: 82.9214
Created: 19-Oct-2021
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_120195454  2 KLVNPmgrqaeTFDTGANYSGisPQSGCICSGSIEAKNAHYQGPTMCVGYCEH-GIDNRNANMEQAYN 68  Lacrimispora algidixylanolytica
AEC03334      3 KIVAG------KLQTGADFEG--SKGGCKCSGGAVVENSHNAGPAYCVGYCGNnGVVTRNANANLART 62  [Ruminococcus] gnavus E1
WP_071144062  3 KIVAG------KLQTGADFEG--SRGDCICSGTIAVKNSHYAGPAYCVGYCGNnGIVTRNANANLAKT 62  Coprococcus phoceensis
WP_151165538  3 KILAG------KLQTGADFEG--SRSGCVCSGSAAVASSHYAGPAYCVGYCGNhGAVTRNANYNLAKK 62  [Ruminococcus] gnavus
WP_021740598  2 KLVTSk-----TMKTGTNFEG--NKAGCICSGSVAVANSHNAGPAYCVGYCGNnGAVTRNANANLART 62  Eubacteriales
WP_151165628  2 KLVKTk-----TMKTGSHFEG--SKAGCICSGSVAVANAHNAGPAYCVGYCGSnGTVTRNANANLART 62  [Ruminococcus] gnavus
WP_071144058  2 RLVQSk-----KIAVGSNFEG--NKAGCICSGSVAVANAHDAGPAYCVGYCGNnGTVTRNANANLART 62  Lachnospiraceae
WP_021740597  2 RLVQSk-----RIATGFNFEG--SKAGCVCSGTVAVANSHNAGPAYCVGYCGNnGEVTRNANYNIARK 62  Eubacteriales
WP_071144061  2 KLVETk-----TTKTGTDFEG--NRAGCICNGTVAVANSHNAGPAYCVGYCGNsGVVTRNANANLART 62  Coprococcus phoceensis
WP_016283201  2 KMVNPmgrtaeSLETGANF-GvtPLSGCVCSDTEELANAHNKGPTKCVGYCLY-GEENKNANMEAAKK 67  Lachnospiraceae bacterium A4
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