Conserved Protein Domain Family
agg_sub_LPXTH

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NF035936: agg_sub_LPXTH 
serine-rich aggregation substance UasX
Members of this protein family are repetitive, serine-rich surface proteins of the Firmicutes, found primarily in the genus Leuconostoc. The variant form of sortase signal, LPXTH, is replaced by LPXTG in members from some lineages, such as Weissella oryzae, and therefore recognizable. Some members of this family have the KxYKxGKxW type signal peptide as seen in the glycoprotein adhesin GspB, a substrate of the accessory Sec system for secretion. WOSG25_050600 from Weissella oryzae SG25 is identified in a publication as an unnamed aggregation substance, a conclusion supported by the sorting signals and composition reported here. We assign the gene symbol uasX (unnamed aggregation substance X) based on our evaluation of the family.
Statistics
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PSSM-Id: 468270
Aligned: 20 rows
Threshold Bit Score: -1
Created: 24-Apr-2023
Updated: 3-May-2023
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_146972969     99 DTSTAQ-SVQATAKSLPQVKAVVLSASTDVVSDASSTVDDGttvdngGTSTDDGTTVDNGGSS----SPSDNGGSSssnd 173 Leuconostoc ...
GDZ83436         32 GTSTVQ-STQANSTVMPQVKAVALTANVDPVASSTSSSGDF------SDNDDSNLPGGDKGSS----SSSDNGGSSsssd 100
2_ncbifamImport   1 DTSTAQ-SIQATSTVLPQVKAVALTASVDPVASATSSSDDF------GDNDDSQLP-DDSESS----SSSDNGSSNsssd 68 
KDA51444         33 ETSTAQ-IVQAT-TVLSQDKAGSLATSLAPVESATSSSDNF------GDNDDSNLPGGDTGSS----SSLDNGSSNssse 100
OQJ81198         27 DTNTVPlTLQATTNVLPQVKAVALTASVNPVASATSSSDDF------GDNDDSNLPGGDTGSS----SSSDNGSSNsssd 96 
WP_027698861     40 VTQSSKtAVDLQANTLSLGTKTVKAASDTPKANTSTPTKANtisiisGKTLNKDI---DDGTS----KDIDDGTGKntdd 112 Weissella or...
WP_027699825     42 ATKASQ-NLQSNTVSL-GTKTTNAAATTNANTTAKTDVINLi----sGKTLNKDI---DDGTG----KDINDGTGTntdd 108 Weissella or...
WP_055308562     35 QTSGSG-FSDNDDSQLPPANTNT------------------------GNTGNTGTPSGTSGAS------------Qstdg 77  Leuconostoc ...
WP_099044373     39 SQPSTQ-PSDTGSTTLPPAQSSSNSDTNSGTGGSSSHTDNS--------SVDDGTHVDNGGSS----------SSGsndk 99  Leuconostoc ...
WP_099044460     43 SQPSTQ-PSDTGSTTLPPAQSGSNSDTNSGTGGSSSNTDNS--------SVDDGTHVDNGGSSssgsNDKGNGSNSsntd 113 Leuconostoc ...
WP_146972969    174 nggssSsENGSSSSSDNGGSSSSSDNGGSssst-ddgtTVDNGGSSSSSDNGGssSSSDNSGsSSSSDNGGSSSSSDNNG 252 Leuconostoc ...
GDZ83436        101 nsgtdT-PAPTPGDDNDNGSTLPDN----------------------------------------------GNSSSNSGG 133
2_ncbifamImport  69 nedtdT-PAPTPGDSEDNGDTLPEDNGGS------------------STDNGG--SSSDNGDsSSSTDSGSSNSSSDQGG 127
KDA51444        101 nsgtdT-PAPTTGDDNDNGSTLPDDNGGS---------SSGNGGSSSSSDNGSssSSTDNGG--SSSDSGSSNSSSDQGG 168
OQJ81198         97 nsgtdT-PTPTPGDDNDNGSTLPDDNSGSssdnggsssSSDNGSSSSSTDNGG--SSSDNGEsSSSSDNGGSNSSSDQGG 173
WP_027698861    113 g--tgknTDDGTGKNTDDGGK--DNNGGS--------------TTDGDKDKGG--STT-----DGDKDKGGSTTDGDKD- 166 Weissella or...
WP_027699825    109 g--tgkdTDNGKGTNTDDGTGKDTDNGKGd--------NTDNGAGGNTDNGGG--KDTDNGT-GGNTDNGSGKDTDNGGK 175 Weissella or...
WP_055308562     78 npasgT-PVPTPSDNQTNGSTLPVSQSGSa--------TSGTNAPSSANSNSA--TSSDAAStSTPTGNQTPVSGTTNTT 146 Leuconostoc ...
WP_099044373    100 g--ngsnSSSTDDKDNSSNSSSTDDKGNG--------------SNSSNTDDKG---------------NGSNSSSTDDKG 148 Leuconostoc ...
WP_099044460    114 d--kgngSNLSNTDDKSNGSNLSNTDDMR------------NGSNSSSTDDKG--NGSISSG-TDDKGNGSNSSSTDDKG 176 Leuconostoc ...
WP_146972969    253 SSSN---GGG--TESSTAGGNGSSSDNNIVPLTPTTPDTNNQGEVNHVKPIEVTPDNSGNVVDVPTQVASVPSIARAVEA 327 Leuconostoc ...
GDZ83436        134 SSSN---NGG--TDNSNAGGSSSSNGNNTVPLTPTTPDKNDQGEINHVKPVDVTPDNSGNAVAVPTQVASVPSVARAVEA 208
2_ncbifamImport 128 SSTD---NSG--TDNSNTGGSNSSTDDHTVPLTPTAPDKNDQGEINHVKPVEVTPDSSGNVVSVPTQVASVPSVARAVES 202
KDA51444        169 SSSN---NGE--TDNSNAGGSISSNDNNIVPLTPSTPDKNDQGEINHVKPVEVTPDSSGNVVLVPTQVASVPSVAISVGS 243
OQJ81198        174 SSNN----GG--TDNSNAGGSSSSNDTNTVPLTPTTPDKNDQGEINHVKPVEVTPDSSGNVVSVPTQVASVLSVARAVEA 247
WP_027698861    167 -------KGGstTDGDKSNGNSTNTDSNSGTVT----------------PVPVHPDNTGNTIQVPTIAQSAPEVAKAVTS 223 Weissella or...
WP_027699825    176 NSNSdkdKGD---STDTGKNDNSNTDSNTVT------------------PVPVQPDNSGNTIQVPTIAQSTPEVAKAVTS 234 Weissella or...
WP_055308562    147 PAPNpapQTT--NPTVNTPLPTHGLAPAPVPLTNSTPDVNDQGELNQVTPVPVQQPSQGQAPVVPVQVASVPSVARAVQD 224 Leuconostoc ...
WP_099044373    149 NGSN---SSN--TDENRLPNNGKAPD--VVPLTPTTPDVNDKGQLNQVALVPVAQPKQGQAQVVPEQVATVPSVARAVEA 221 Leuconostoc ...
WP_099044460    177 NGSN---SSN--TDENRLPNNGKAPD--VVPLTPTTPDVNDKGQLNQVAPVPVAEPKQGQAPVVPEQVATVPSVARAVEA 249 Leuconostoc ...
WP_146972969    328 YNQALTANDKDATKAPVVEAKQKLDDAVAKALPLTHATEKSSmgGNGILAlAMSGLVAF-GGLIYKRKH 395 Leuconostoc citreum
GDZ83436        209 YNQALTANDKDANNAKVVEAKKKLDDAVAKALPDTHATQPKS--SIGILS-AISGVLAMtGALIFKRFK 274
2_ncbifamImport 203 YNQALTANDKDANNDKVVEAKQKLDDAVAKVLPETHATQAKS--SIGILS-AVSGVLAMtGALIFKRFK 268
KDA51444        244 YNQALTANDKDANNAKVVEAKQKLDDAVAKALPETHATQAKS--SIGILS-AVSGVLAMtGALIFKRFK 309
OQJ81198        248 YNQVLTANDKDASNDKVVEAKQKLDDAVAKALPETHATQTKS--SIGILS-AVSGVLAMtGALIFKHFK 313
WP_027698861    224 YNQALADNNGDSNAAAVVQAKEAVNKAVADTLPETGFTDQAGfsVAGIVLtAIAGLF---GFLKFKKn- 288 Weissella oryzae
WP_027699825    235 YNQALADNNGDSNAAAVVQAKDAVNKAVADALPETGYTEQAGlsVAGLILtAIASLF---GILKFKKIN 300 Weissella oryzae
WP_055308562    225 YNQALTSNGNNGNNDKVVEAKQKLDDAVAKALPETHAQQPKS--NIGILS-AMAGILALsGVFLFKRFK 290 Leuconostoc lactis
WP_099044373    222 YNATLSSNNSDATQAPVIEAKKKVDDAVLKALPKTGVRQKQS--SVSVLGiALTALASG-LAFVFKKKL 287 Leuconostoc citreum
WP_099044460    250 YNATLSSNNSDATQAPVIEAKKKVDDAVLKALPKTGVRQKQS--SVSVLGiALTALASG-LAFVFKKKL 315 Leuconostoc citreum
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