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T3SS regulon translocated regulator ExsE2 ExsE2, as described in two Vibrio species, is called functionally equivalent to ExsE from Pseudomonas aeruginosa, but appears to lack detectable sequence homology. In each model organism, a type III secretion system (T3SS) contains a DNA-binding transcriptional activator ExsA, an anti-activator ExsD that binds ExsA and inhibits its activity, and a secretion chaperone ExsC that can bind to and counteract ExsD. ExsE2 (in V. alginolyticus) or ExsE (in P. aeruginosa) can bind its chaperone ExsC until it exits the cell by successful T3SS translocation, providing fine tuning of T3SS gene expression through these interactions. We renamed the Vibrio family from ExsE to ExsE2 to help minimize confusion between these two very dissimilar families. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",